The Influenza Vaccine May Protect Pregnant and Postpartum Women against Severe COVID-19

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPAGANOTI, Cristiane de Freitas
dc.contributor.authorRODRIGUES, Agatha Sacramento
dc.contributor.authorFRANCISCO, Rossana Pulcineli Vieira
dc.contributor.authorCOSTA, Rafaela Alkmin da
dc.date.accessioned2022-04-19T13:02:24Z
dc.date.available2022-04-19T13:02:24Z
dc.date.issued2022
dc.description.abstractThe SARS-CoV-2 pandemic has imposed a huge challenge on the antenatal care of pregnant women worldwide, with the maternal mortality rate being raised to alarming levels. While COVID-19 vaccines were developed, some studies highlighted a possible relationship between influenza vaccination and lower odds of COVID-19 infection. As obstetric patients belong to a high-risk group for respiratory diseases, this study evaluated whether influenza vaccination reduces the severity of COVID-19 infection and mortality among pregnant and postpartum women. We conducted a retrospective cohort study on 3370 pregnant and postpartum women from the Brazilian national database, where they were grouped according to their influenza vaccination status before the onset of COVID-19 symptoms. The intensive care unit admission and intubation rates were significantly higher among subjects in the unvaccinated group (p = 0.002 and p < 0.001, respectively). The odds of mortality risk among those who received the vaccine was 0.33, with a 95% confidence interval of 0.23-0.47. The numbers of patients who needed to be vaccinated to avoid a case of intensive care unit admission, intubation, or death due to COVID-19 were 11, 15, and 11, respectively. Influenza vaccines could confer protection against severe COVID-19 infection in pregnant and postpartum women.eng
dc.description.indexPubMedeng
dc.description.sponsorshipBill & Melinda Gates FoundationBill & Melinda Gates FoundationCGIAR [INV-027961]
dc.description.sponsorshipCNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [445881/2020-8]
dc.description.sponsorshipFAPESFundacao de Amparo a Pesquisa do Estado de Espiritu Santo (FAPES) [007/2021]
dc.identifier.citationVACCINES, v.10, n.2, article ID 206, 11p, 2022
dc.identifier.doi10.3390/vaccines10020206
dc.identifier.eissn2076-393X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/46006
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofVaccines
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectpregnancyeng
dc.subjectCOVID-19eng
dc.subjectinfluenza vaccineseng
dc.subjectmaternal mortalityeng
dc.subject.wosImmunologyeng
dc.subject.wosMedicine, Research & Experimentaleng
dc.titleThe Influenza Vaccine May Protect Pregnant and Postpartum Women against Severe COVID-19eng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalRODRIGUES, Agatha Sacramento:Univ Fed Espirito Santo, Dept Stat, BR-29075910 Vitoria, ES, Brazil
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcCRISTIANE DE FREITAS PAGANOTI
hcfmusp.contributor.author-fmusphcROSSANA PULCINELI VIEIRA FRANCISCO
hcfmusp.contributor.author-fmusphcRAFAELA ALKMIN DA COSTA
hcfmusp.description.articlenumber206
hcfmusp.description.issue2
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed35214665
hcfmusp.origem.scopus2-s2.0-85123978137
hcfmusp.origem.wosWOS:000762193500001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/57
Artigos e Materiais de Revistas Científicas - ODS/03