Sex Differences in Heart Failure Mortality with Preserved, Mildly Reduced and Reduced Ejection Fraction: A Retrospective, Single-Center, Large-Cohort Study
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Citações na Scopus
4
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Citação
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.19, n.23, article ID 16171, 13p, 2022
Resumo
Background: Heart failure (HF) is one of the leading causes of death worldwide. Studies show that women have better survival rates than men despite higher hospitalizations. However, little is known about differences in mortality and predictors of death in women and men with HF with preserved (HFpEF), mildly reduced (HFmrEF), and reduced ejection fraction (HFrEF). Methods: From February 2017 to September 2020, mortality and predictors of death were analyzed in women and men with HF. Baseline data included clinical characteristics and echocardiographic findings. Results: A total of 11,282 patients, 63.9 +/- 14.4 years, including 6256 (55.4%) males, were studied. Females were older, had a higher baseline mean left ventricular ejection fraction (LVEF) and lower left ventricular diastolic diameter. During follow-ups, 1375 (22%) men and 925 (18.4%) women died. Cumulative incidence of death was higher in men with HFrEF but similar for HFmrEF and HFpEF. Cox regression for death showed renal dysfunction, stroke, diabetes, atrial fibrillation, age, LVEF, valve disease, MI, and hypertensive CMP as independent death predictors for all HF patients. Conclusions: Women had a better prognosis than men in HFrEF and similar mortality for HFmrEF and HFpEF, but sex was not an independent predictor of death for all HF subtypes.
Palavras-chave
heart failure, cardiomyopathy, left ventricular ejection fraction, prognosis, women, men
Referências
- Alenazy B, 2019, ESC HEART FAIL, V6, P1283, DOI 10.1002/ehf2.12525
- Arruda Vilmeyze Larissa de, 2022, Rev Bras Epidemiol, V25, pE220021, DOI 10.1590/1980-549720220021.2
- Beale AL, 2018, CIRCULATION, V138, P198, DOI 10.1161/CIRCULATIONAHA.118.034271
- Bibbins-Domingo K, 2004, J AM COLL CARDIOL, V44, P1593, DOI 10.1016/j.jacc.2004.07.040
- Brasil. Receita Federal, 2022, BRASILIA
- Butler J, 2022, CIRCULATION, V146, P1046, DOI 10.1161/CIRCULATIONAHA.122.059755
- De Bellis A, 2020, HEART FAIL REV, V25, P245, DOI 10.1007/s10741-019-09824-y
- Dewan P, 2019, J AM COLL CARDIOL, V73, P29, DOI 10.1016/j.jacc.2018.09.081
- Dunlay Shannon M, 2012, Curr Heart Fail Rep, V9, P267, DOI 10.1007/s11897-012-0107-7
- Farre N, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-018719
- Gerber Y, 2015, JAMA INTERN MED, V175, P996, DOI 10.1001/jamainternmed.2015.0924
- Grupper A, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.1012361
- Ho J.E, 2015, CIRCULATION, V132, pA11958, DOI [10.1161/circ.132.suppl_3.11958, DOI 10.1161/CIRC.132.SUPPL_3.11958]
- Ho JE, 2012, EUR HEART J, V33, P1734, DOI 10.1093/eurheartj/ehs070
- Hsich EM, 2009, J AM COLL CARDIOL, V54, P491, DOI 10.1016/j.jacc.2009.02.066
- Koh AS, 2017, EUR J HEART FAIL, V19, P1624, DOI 10.1002/ejhf.945
- Komukai K, 2010, FUND CLIN PHARMACOL, V24, P687, DOI 10.1111/j.1472-8206.2010.00854.x
- Lam CSP, 2012, CIRC-HEART FAIL, V5, P571, DOI 10.1161/CIRCHEARTFAILURE.112.970061
- Li Le, 2023, Int J Cardiol, V371, P191, DOI 10.1016/j.ijcard.2022.09.064
- Lloyd-Jones DM, 2002, CIRCULATION, V106, P3068, DOI 10.1161/01.CIR.0000039105.49749.6F
- Lund LH, 2018, EUR J HEART FAIL, V20, P1230, DOI 10.1002/ejhf.1149
- Madan N, 2019, HEART FAIL CLIN, V15, P55, DOI 10.1016/j.hfc.2018.08.006
- Magnussen C, 2019, JACC-HEART FAIL, V7, P204, DOI 10.1016/j.jchf.2018.08.008
- Martinez-Selles M, 2012, EUR J HEART FAIL, V14, P473, DOI 10.1093/eurjhf/hfs026
- MCKEE PA, 1971, NEW ENGL J MED, V285, P1441, DOI 10.1056/NEJM197112232852601
- Oneglia Andrew, 2020, Curr Heart Fail Rep, V17, P409, DOI 10.1007/s11897-020-00487-7
- Pandey A, 2018, CIRCULATION, V137, P1814, DOI 10.1161/CIRCULATIONAHA.117.031622
- Rodgers JL, 2019, J CARDIOVASC DEV DIS, V6, DOI 10.3390/jcdd6020019
- Roger VL, 2004, JAMA-J AM MED ASSOC, V292, P344, DOI 10.1001/jama.292.3.344
- Savarese G, 2022, CARDIOVASC RES, DOI 10.1093/cvr/cvac013
- Savarese G, 2022, NAT REV CARDIOL, V19, P100, DOI 10.1038/s41569-021-00605-5
- Savarese G, 2019, JACC-HEART FAIL, V7, P306, DOI 10.1016/j.jchf.2018.11.019
- Spitaleri G, 2022, J CLIN MED, V11, DOI 10.3390/jcm11030784
- Stolfo D, 2019, JACC-HEART FAIL, V7, P505, DOI 10.1016/j.jchf.2019.03.011
- Thompson LE, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005801
- Tsao CW, 2018, JACC-HEART FAIL, V6, P678, DOI 10.1016/j.jchf.2018.03.006
- Ventura-Clapier R, 2017, CLIN SCI, V131, P803, DOI 10.1042/CS20160485
- Wang Xiaowen, 2022, Circulation, DOI 10.1161/CIRCULATIONAHA.122.062832
- Zhao Z, 2014, AM J PHYSIOL-HEART C, V306, pH628, DOI 10.1152/ajpheart.00859.2013