Neutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid: Relation to Bacterial Vaginosis and Vulvovaginal Candidiasis

Imagem de Miniatura
Arquivos
art_BEGHINI_Neutrophil_GelatinaseAssociated_Lipocalin_Concentration_in_Vaginal_Fluid_Relation_2015.PDF (163.3 KB)
Citações na Scopus
29
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SAGE PUBLICATIONS INC
Autores
BEGHINI, Joziani
GIRALDO, Paulo C.
LEDGER, William J.
WITKIN, Steven S.
Citação
REPRODUCTIVE SCIENCES, v.22, n.8, p.964-968, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is a component of innate immunity that prevents iron uptake by microorganisms. We evaluated whether NGAL was present in vaginal fluid and whether concentrations were altered in women with bacterial vaginosis (BV) or vulvovaginal candidiasis (VVC). Methods: Vaginal secretions from 52 women with VVC, 43 with BV, and 77 healthy controls were assayed by enzyme-linked immunosorbent assay for NGAL and for concentrations of l-lactic acid. Results: The median concentration of NGAL in vaginal fluid was significantly higher in control women (561 pg/mL) than in women with BV (402 pg/mL; P = .0116) and lower in women with VVC (741 pg/mL; P = .0017). Median lactic acid levels were similar in controls (0.11 mmol/L) and women with VVC (0.13 mmol/L) and were lower in women with BV (0.02 mmol/L; P < .0001). The NGAL and lactic acid concentrations were highly correlated (P < .0001). Conclusion: A decrease in Lactobacilli and/or lactic acid plus the absence of leukocytes results in lower vaginal NGAL levels that might facilitate the growth of bacteria associated with BV.
Palavras-chave
neutrophil gelatinase-associated lipocalin (NGAL), bacterial vaginosis, vulvovaginal candidiasis, vaginal fluid, innate anti-microbial immunity
URI
https://observatorio.fm.usp.br/handle/OPI/12025
Referências
  1. AMSEL R, 1983, AM J MED, V74, P14, DOI 10.1016/0002-9343(83)91112-9
  2. Biagi E, 2009, EUR J CLIN MICROBIOL, V28, P281, DOI 10.1007/s10096-008-0617-0
  3. Bolignano D, 2012, CANC LETT, V288, P10
  4. Cowland JB, 2003, J IMMUNOL, V171, P6630
  5. D'Anna R, 2009, DIABETIC MED, V26, P1293, DOI 10.1111/j.1464-5491.2009.02830.x
  6. Donders G, 2010, OBSTET GYNECOL SURV, V65, P462, DOI 10.1097/OGX.0b013e3181e09621
  7. Ferreira MC, 2014, INFECT IMMUN, V82, P1030, DOI 10.1128/IAI.01389-13
  8. Fichorova RN, 2002, J IMMUNOL, V168, P2424
  9. Flo TH, 2004, NATURE, V432, P917, DOI 10.1038/nature03104
  10. Haase M, 2010, CURR OPIN CRIT CARE, V16, P526, DOI 10.1097/MCC.0b013e328340063b
  11. Jarosik GP, 1998, INFECT IMMUN, V66, P5041
  12. Mossop H, 2011, OBSTET GYNECOL, V118, P840, DOI 10.1097/AOG.0b013e31822da9e9
  13. NUGENT RP, 1991, J CLIN MICROBIOL, V29, P297
  14. Schmidt-Ott KM, 2007, J AM SOC NEPHROL, V18, P407, DOI 10.1681/ASN.2006080882
  15. Shime H, 2008, J IMMUNOL, V180, P7175
  16. Sobel JD, 1998, AM J OBSTET GYNECOL, V178, P203, DOI 10.1016/S0002-9378(98)80001-X
  17. Tadesse S, 2011, REPROD SCI, V18, P713, DOI 10.1177/1933719110396722
  18. Witkin SS, 2011, FEMS IMMUNOL MED MIC, V61, P153, DOI 10.1111/j.1574-695X.2010.00757.x
  19. Zhou X, 2009, INFECT IMMUN, V77, P4130, DOI 10.1128/IAI.00436-09

Coleções
Artigos e Materiais de Revistas Científicas - LIM/58
Artigos e Materiais de Revistas Científicas - HC/ICHC