High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3

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art_CAVALCANTE_High_18FFDG_uptake_in_PMAH_correlated_with_normal_2016.PDF (798.86 KB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SAGE PUBLICATIONS LTD
Autores
CAVALCANTE, Isadora Pontes
ALENCAR, Guilherme Asmar
Citação
ACTA RADIOLOGICA, v.57, n.3, p.370-377, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background Primary macronodular adrenal hyperplasia (PMAH) is a rare cause of Cushing's syndrome, characterized by functioning adrenal macronodules and variable cortisol production. Recently, we demonstrated a high 18F-FDG uptake in PMAH, an unexpected finding for a benign disorder. Purpose To investigate whether there is a correlation between 18F-FDG high uptake and the expression levels of the glycolytic pathway components GLUT1, HK1, HK2, and HK3 in PMAH. Material and Methods We selected 12 patients undergoing surgery for PMAH who had preoperatively undergone 18F-FDG PET/CT. mRNA and protein expression of the selected genes were evaluated in the adrenal nodules from patients who underwent surgery through quantitative RT-PCR and by immunohistochemistry, respectively. Results SUVmax in PMAH was in the range of 3.3-8.9 and the adrenal size was in the range of 3.5-15cm. A strong correlation between 18F-FDG uptake and largest adrenal diameter was observed in patients with PMAH. However, no correlation between 18F-FDG uptake and GLUT1, HK1, HK2, HK3 mRNA, and protein expression was observed. Conclusion High 18F-FDG uptake is observed in the majority of PMAH cases. However, 18F-FDG uptake in PMAH is independent of the expression levels of GLUT1, HK1, HK2, and HK3. Further investigation is required to elucidate the molecular mechanisms underlying increased 18F-FDG uptake in PMAH.
Palavras-chave
Primary macronodular adrenal hyperplasia, 18F-FDG, PET, adrenal, adults, hyperplasia, monoclonal antibodies, Cushing's syndrome
URI
https://observatorio.fm.usp.br/handle/OPI/13977
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