Glycogen Synthase Kinase-3 beta: Variation over Time and the Possible Association with Mood and Cognition in Healthy Individuals
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Citações na Scopus
5
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
KARGER
Autores
MUNKHOLM, Klaus
LENSKJOLD, Toke
JACOBY, Anne Sophie
MISKOWIAK, Kamilla Woznica
VINBERG, Maj
JOAQUIM, Helena Giroud Passarelli
KESSING, Lars Vedel
Citação
NEUROPSYCHOBIOLOGY, v.73, n.2, p.108-115, 2016
Resumo
Evidence indicates a role for glycogen synthase kinase-3 beta (GSK-3 beta) in the pathophysiology of mood disorders and in cognitive disturbances; however, the natural variation in GSK-3 beta activity over time is unknown. We aimed to investigate GSK-3 beta activity over time and its possible correlation with emotional lability, subjective mood fluctuations and cognitive function in healthy individuals. Thirty-seven healthy subjects were evaluated with neuropsychological tests and blood samples at baseline and 12-week follow-up. Total GSK-3 beta and serine-9-phosphorylated GSK-3 beta in peripheral blood mononuclear cells were quantitated using enzyme immunometric assays. The activity of GSK-3 beta (serine-9-phosphorylated GSK-3 beta/total GSK-3 beta) was lower at baseline compared with follow-up. No significant mean change over time was observed in levels of total GSK-3 beta and serine-9-phosphorylated GSK-3 beta. Exploratory analysis revealed lower activity of GSK-3 beta in spring and summer compared with the fall season. No correlation was observed between GSK-3 beta activity and emotional lability, subjective mood fluctuations or cognitive function. The results suggest that intra- and interindividual variation in GSK-3 beta activity over time could contribute to the heterogeneity of findings in clinical studies. The stability of GSK-3 beta activity and the role of potential moderators of GSK-3 beta activity warrant further investigation. Clinical studies of GSK-3 beta should consider including repeated measures of both cases and healthy individuals. (C) 2016 S. Karger AG, Basel
Palavras-chave
Bipolar disorder, Peripheral blood, Biomarker
Referências
- Atsma F, 2011, TRANSFUSION, V51, P1883, DOI 10.1111/j.1537-2995.2011.03270.x
- Castri P, 2007, EUR J NEUROSCI, V26, P2469, DOI 10.1111/j.1460-9568.2007.05869.x
- Geddes JR, 2010, LANCET, V375, P385, DOI 10.1016/S0140-6736(09)61828-6
- Kessing LV, 2010, BIPOLAR DISORD, V12, P87, DOI 10.1111/j.1399-5618.2009.00788.x
- Munkholm K, 2015, BIPOLAR DISORD, V17, P257, DOI 10.1111/bdi.12245
- HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
- Polter A, 2010, NEUROPSYCHOPHARMACOL, V35, P1761, DOI 10.1038/npp.2010.43
- Kessing LV, 2004, J NEUROL NEUROSUR PS, V75, P1662, DOI 10.1136/jnnp.2003.031773
- Munkholm K, 2012, BIPOLAR DISORD, V14, P684, DOI 10.1111/bdi.12005
- Karege F, 2012, J AFFECT DISORDERS, V136, P185, DOI 10.1016/j.jad.2011.09.024
- Besing RC, 2015, J BIOL RHYTHM, V30, P155, DOI 10.1177/0748730415573167
- Munkholm K, 2015, BRAIN BEHAV IMMUN, V43, P205, DOI 10.1016/j.bbi.2014.09.021
- Sullivan PF, 2006, AM J MED GENET B, V141B, P261, DOI 10.1002/ajmg.b.30272
- Kessing LV, 1999, ACTA PSYCHIAT SCAND, V100, P176, DOI 10.1111/j.1600-0447.1999.tb10843.x
- Munkholm K, 2013, J PSYCHIATR RES, V47, P1119, DOI 10.1016/j.jpsychires.2013.05.018
- Munkholm K, 2014, PSYCHONEUROENDOCRINO, V47, P199, DOI 10.1016/j.psyneuen.2014.05.011
- Stambolic V, 1996, CURR BIOL, V6, P1664, DOI 10.1016/S0960-9822(02)70790-2
- Gladkevich A, 2004, PROG NEURO-PSYCHOPH, V28, P559, DOI 10.1016/j.pnpbo.2004.01.009
- Martin M, 2005, NAT IMMUNOL, V6, P777, DOI 10.1038/ni1221
- Jope RS, 2007, NEUROCHEM RES, V32, P577, DOI 10.1007/s11064-006-9128-5
- Kapczinski F, 2008, NEUROSCI BIOBEHAV R, V32, P675, DOI 10.1016/j.neubiorev.2007.10.005
- Diniz BS, 2011, WORLD J BIOL PSYCHIA, V12, P216, DOI 10.3109/15622975.2010.551408
- Leonard B, 2012, NEUROSCI BIOBEHAV R, V36, P764, DOI 10.1016/j.neubiorev.2011.12.005
- Joaquim HPG, 2012, J PSYCHIATR RES, V46, P1053, DOI 10.1016/j.jpsychires.2012.04.020
- Karege F, 2007, BIOL PSYCHIAT, V61, P240, DOI 10.1016/j.biopsych.2006.04.036
- Pandey GN, 2010, J PSYCHIATR RES, V44, P143, DOI 10.1016/j.jpsychires.2009.07.009
- Kessing LV, 2011, BRIT J PSYCHIAT, V199, P57, DOI 10.1192/bjp.bp.110.084822
- Kim HW, 2011, MOL PSYCHIATR, V16, P419, DOI 10.1038/mp.2009.137
- WING JK, 1990, ARCH GEN PSYCHIAT, V47, P589
- Bazinet RP, 2006, BIOL PSYCHIAT, V59, P401, DOI 10.1016/j.biopsych.2005.07.024
- Klein PS, 1996, P NATL ACAD SCI USA, V93, P8455, DOI 10.1073/pnas.93.16.8455
- Kessing LV, 2008, ARCH GEN PSYCHIAT, V65, P1331, DOI 10.1001/archpsyc.65.11.1331
- Cheon Y, 2011, J NEUROCHEM, V119, P364, DOI 10.1111/j.1471-4159.2011.07410.x
- Hoehn KL, 2004, AM J PHYSIOL-REG I, V286, pR498, DOI 10.1152/ajpregu.00509.2003
- Nunes PV, 2007, BRIT J PSYCHIAT, V190, P359, DOI 10.1192/bjp.bp.106.029868
- Marksteiner J, 2009, EXP GERONTOL, V44, P370, DOI 10.1016/j.exger.2009.02.007
- Forlenza OV, 2011, BRIT J PSYCHIAT, V198, P351, DOI 10.1192/bjp.bp.110.080044
- Patel S, 2008, MOL CELL BIOL, V28, P6314, DOI 10.1128/MCB.00763-08
- MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
- Hye A, 2005, NEUROSCI LETT, V373, P1, DOI 10.1016/j.neulet.2004.10.031
- YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
- Ryves WJ, 2001, BIOCHEM BIOPH RES CO, V280, P720, DOI 10.1006/bbrc.2000.4169
- Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
- Petersen ML, 2006, EPIDEMIOLOGY, V17, P276, DOI 10.1097/01.ede.0000208475.99429.2d
- Li XH, 2010, BIPOLAR DISORD, V12, P741, DOI 10.1111/j.1399-5618.2010.00866.x
- Derogatis L, 1983, BRIEF SYMPTOM INVENT, V13, P595, DOI 10.1017/S0033291700048017
- Goldstein BI, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0425-9
- Kaladchibachi Sevag A, 2007, J Circadian Rhythms, V5, P3, DOI 10.1186/1740-3391-5-3
- King MK, 2014, PHARMACOL THERAPEUT, V141, P1, DOI 10.1016/j.pharmthera.2013.07.010
- Munkholm K, 2015, INT J NEUROPSYCHOPH, V18
- Peineau S, 2008, BRIT J PHARMACOL, V153, pS428, DOI 10.1038/bjp.2008.2
- Randolph C., 1998, RBANS MANUAL REPEATA
- Torres IJ, 2007, ACTA PSYCHIAT SCAND, V116, P17, DOI 10.1111/j.1600-0447.2007.01055.x
- War Department AGsO, 1944, ARM IND TEST BATT MA
- WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
- Wechsler D, 1997, WECHSLER ADULT INTEL
- WOODGETT JR, 1990, EMBO J, V9, P2431