Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/17943
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorALMEIDA, Danilo Candido de-
dc.contributor.authorBASSI, Enio Jose-
dc.contributor.authorAZEVEDO, Hatylas-
dc.contributor.authorANDERSON, Leticia-
dc.contributor.authorORIGASSA, Clarice Silvia Taemi-
dc.contributor.authorCENEDEZE, Marcos Antonio-
dc.contributor.authorANDRADE-OLIVEIRA, Vinicius de-
dc.contributor.authorFELIZARDO, Raphael Jose Ferreira-
dc.contributor.authorSILVA, Reinaldo Correia da-
dc.contributor.authorHIYANE, Meire Ioshie-
dc.contributor.authorSEMEDO, Patricia-
dc.contributor.authorREIS, Marlene Antonia dos-
dc.contributor.authorMOREIRA-FILHO, Carlos Alberto-
dc.contributor.authorVERJOVSKI-ALMEIDA, Sergio-
dc.contributor.authorPACHECO-SILVA, Alvaro-
dc.contributor.authorCAMARA, Niels Olsen Saraiva-
dc.date.accessioned2017-02-16T12:46:22Z-
dc.date.available2017-02-16T12:46:22Z-
dc.date.issued2017-
dc.identifier.citationFRONTIERS IN IMMUNOLOGY, v.7, article ID 645, 18p, 2017-
dc.identifier.issn1664-3224-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/17943-
dc.description.abstractMesenchymal stromal cells (MSCs) orchestrate tissue repair by releasing cell-derived microvesicles (MVs), which, presumably by small RNA species, modulate global gene expression. The knowledge of miRNA/mRNA signatures linked to a reparative status may elucidate some of the molecular events associated with MSC protection. Here, we used a model of cisplatin-induced kidney injury (acute kidney injury) to assess how MSCs or MVs could restore tissue function. MSCs and MVs presented similar protective effects, which were evidenced in vivo and in vitro by modulating apoptosis, inflammation, oxidative stress, and a set of prosurvival molecules. In addition, we observed that miRNAs (i.e., miR-880, miR-141, miR-377, and miR-21) were modulated, thereby showing active participation on regenerative process. Subsequently, we identified that MSC regulates a particular miRNA subset which mRNA targets are associated with Wnt/TGF-beta fibrosis, and epithelial-mesenchymal transition signaling pathways. Our results suggest that MSCs release MVs that transcriptionally reprogram injured cells, thereby modulating a specific miRNA-mRNA network.-
dc.description.sponsorshipSao Paulo Research Public Foundation FAPESP-
dc.description.sponsorshipFluid Complex INCT-
dc.description.sponsorshipMS/DECIT/CNPq [07/07193-3, 12/02270-2]-
dc.language.isoeng-
dc.publisherFRONTIERS MEDIA SA-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsopenAccess-
dc.subjectmesenchymal stromal cells-
dc.subjectmicrovesicles-
dc.subjectmiRNAs-
dc.subjectgene expression-
dc.subjectcellular reprograming-
dc.subject.otherstem-cells-
dc.subject.otherextracellular vesicles-
dc.subject.othergenetic information-
dc.subject.othercyclin-e-
dc.subject.othermicrovesicles-
dc.subject.othermicrornas-
dc.subject.otherexpression-
dc.subject.otherexosomes-
dc.subject.otherrat-
dc.subject.othernephrotoxicity-
dc.titleA Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury-
dc.typearticle-
dc.rights.holderCopyright FRONTIERS MEDIA SA-
dc.identifier.doi10.3389/fimmu.2016.00645-
dc.identifier.pmid28096802-
dc.subject.wosImmunology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalALMEIDA, Danilo Candido de:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil; Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-
hcfmusp.author.externalBASSI, Enio Jose:Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil; Univ Fed Alagoas, Inst Ciencias Biol & Saude, Maceio, Brazil-
hcfmusp.author.externalANDERSON, Leticia:Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil; Inst Butantan, Sao Paulo, Brazil-
hcfmusp.author.externalORIGASSA, Clarice Silvia Taemi:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-
hcfmusp.author.externalCENEDEZE, Marcos Antonio:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-
hcfmusp.author.externalANDRADE-OLIVEIRA, Vinicius de:Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-
hcfmusp.author.externalFELIZARDO, Raphael Jose Ferreira:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-
hcfmusp.author.externalSILVA, Reinaldo Correia da:Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-
hcfmusp.author.externalHIYANE, Meire Ioshie:Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-
hcfmusp.author.externalSEMEDO, Patricia:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-
hcfmusp.author.externalREIS, Marlene Antonia dos:Univ Fed Triangulo Mineiro, Dept Patol, Uberaba, Brazil-
hcfmusp.author.externalVERJOVSKI-ALMEIDA, Sergio:Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil; Inst Butantan, Sao Paulo, Brazil-
hcfmusp.author.externalPACHECO-SILVA, Alvaro:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-
hcfmusp.author.externalCAMARA, Niels Olsen Saraiva:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil; Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-
hcfmusp.description.articlenumber645-
hcfmusp.description.volume7-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-85012077586-
hcfmusp.origem.idWOS:000391055300002-
hcfmusp.publisher.cityLAUSANNE-
hcfmusp.publisher.countrySWITZERLAND-
hcfmusp.relation.referenceAkhmetshina A, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms1734-
hcfmusp.relation.referenceAlers S, 2012, CELL COMMUN SIGNAL, V10, DOI 10.1186/1478-811X-10-7-
hcfmusp.relation.referenceBian SY, 2014, J MOL MED, V92, P387, DOI 10.1007/s00109-013-1110-5-
hcfmusp.relation.referenceBonventre JV, 2009, J AM SOC NEPHROL, V20, P927, DOI 10.1681/ASN.2009030322-
hcfmusp.relation.referenceBruno S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033115-
hcfmusp.relation.referenceBruno S, 2009, STEM CELLS DEV, V18, P867, DOI 10.1089/scd.2008.0320-
hcfmusp.relation.referenceCamussi G, 2013, BIOCHEM SOC T, V41, P283, DOI 10.1042/BST20120192-
hcfmusp.relation.referenceCamussi G, 2010, CURR OPIN NEPHROL HY, V19, P7, DOI 10.1097/MNH.0b013e328332fb6f-
hcfmusp.relation.referenceCarew RM, 2012, CELL TISSUE RES, V347, P103, DOI 10.1007/s00441-011-1227-1-
hcfmusp.relation.referenceCollino F, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011803-
hcfmusp.relation.referenceCorrea-Costa M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049569-
hcfmusp.relation.referencede Almeida Danilo C, 2013, Clin Biochem Rev, V34, P131-
hcfmusp.relation.referenceDealy MJ, 1999, NAT GENET, V23, P245-
hcfmusp.relation.referenceDelfino KR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058608-
hcfmusp.relation.referenceDiMarino AM, 2013, FRONT IMMUNOL, V4, DOI 10.3389/fimmu.2013.00201-
hcfmusp.relation.referenceDressler GR, 2006, ANNU REV CELL DEV BI, V22, P509, DOI 10.1146/annurev.cellbio.22.010305.104340-
hcfmusp.relation.referenceHuang Q, 2001, TOXICOL SCI, V63, P196, DOI 10.1093/toxsci/63.2.196-
hcfmusp.relation.referenceHwang I, 2009, ARCH PHARM RES, V32, P1653, DOI 10.1007/s12272-009-2200-3-
hcfmusp.relation.referenceKillcoyne S, 2009, METHODS MOL BIOL, V563, P219, DOI 10.1007/978-1-60761-175-2_12-
hcfmusp.relation.referenceLai RC, 2010, STEM CELL RES, V4, P214, DOI 10.1016/j.scr.2009.12.003-
hcfmusp.relation.referenceLan HY, 2011, CONTRIB NEPHROL, V170, P75, DOI 10.1159/000324949-
hcfmusp.relation.referenceLe Bechec A, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-67-
hcfmusp.relation.referenceLee C, 2012, CIRCULATION, V126, P2601, DOI 10.1161/CIRCULATIONAHA.112.114173-
hcfmusp.relation.referenceLee EJ, 2011, AUTOPHAGY, V7, P689, DOI 10.4161/auto.7.7.15450-
hcfmusp.relation.referenceLee Y, 2012, HUM MOL GENET, V21, pR125, DOI 10.1093/hmg/dds317-
hcfmusp.relation.referenceLin SS, 2014, NEUROCHEM RES, V39, P922, DOI 10.1007/s11064-014-1288-0-
hcfmusp.relation.referenceMa Seong Kwon, 2013, [Chonnam Medical Journal, 전남의대학술지], V49, P108, DOI 10.4068/cmj.2013.49.3.108-
hcfmusp.relation.referenceMorel O, 2004, CURR OPIN HEMATOL, V11, P156, DOI 10.1097/01.moh.0000131441.10020.87-
hcfmusp.relation.referencePandey P, 2011, BMC SYST BIOL, V5, DOI 10.1186/1752-0509-5-56-
hcfmusp.relation.referencePirooznia Mehdi, 2007, Bioinformation, V1, P420-
hcfmusp.relation.referenceRaisi A, 2014, J TRAUMA ACUTE CARE, V76, P991, DOI 10.1097/TA.0000000000000186-
hcfmusp.relation.referenceRaposo G, 2013, J CELL BIOL, V200, P373, DOI 10.1083/jcb.201211138-
hcfmusp.relation.referenceSaal S, 2009, CURR OPIN NEPHROL HY, V18, P317, DOI 10.1097/MNH.0b013e32832c9da2-
hcfmusp.relation.referenceSenanayake U, 2012, CARCINOGENESIS, V33, P1014, DOI 10.1093/carcin/bgs126-
hcfmusp.relation.referenceTetta C, 2013, ENDOCRINE, V44, P11, DOI 10.1007/s12020-012-9839-0-
hcfmusp.relation.referenceThompson KL, 2004, ENVIRON HEALTH PERSP, V112, P488, DOI 10.1289/txg.6676-
hcfmusp.relation.referenceValtieri M, 2008, J CELL PHYSIOL, V217, P296, DOI 10.1002/jcp.21521-
hcfmusp.relation.referenceVlachos IS, 2012, NUCLEIC ACIDS RES, V40, pW498, DOI 10.1093/nar/gks494-
hcfmusp.relation.referenceWang G, 2010, DIS MARKERS, V28, P79, DOI 10.3233/DMA-2010-0687-
hcfmusp.relation.referenceWang Q, 2008, FASEB J, V22, P4126, DOI 10.1096/fj.08-112326-
hcfmusp.relation.referenceWang XM, 2014, AM J PHYSIOL-RENAL, V306, pF205, DOI 10.1152/ajprenal.90005.2013-
hcfmusp.relation.referenceWang YS, 1999, CURR BIOL, V9, P1191, DOI 10.1016/S0960-9822(00)80024-X-
hcfmusp.relation.referenceXin H, 2013, CEREB BLOOD FLOW MET, V33, P1711-
hcfmusp.relation.referenceXiong MX, 2012, AM J PHYSIOL-RENAL, V302, pF369, DOI 10.1152/ajprenal.00268.2011-
hcfmusp.relation.referenceYan J, 1999, ONCOGENE, V18, P5850, DOI 10.1038/sj.onc.1202988-
hcfmusp.relation.referenceZhang B, 2014, STEM CELLS DEV, V23, P1233, DOI 10.1089/scd.2013.0479-
hcfmusp.relation.referenceZhu YG, 2014, STEM CELLS, V32, P116, DOI 10.1002/stem.1504-
dc.description.indexPubMed-
hcfmusp.citation.scopus29-
hcfmusp.scopus.lastupdate2022-06-24-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica


Files in This Item:
File Description SizeFormat 
art_ALMEIDA_A_Regulatory_miRNAmRNA_Network_Is_Associated_with_Tissue_2017.PDFpublishedVersion (English)8.17 MBAdobe PDFThumbnail
View/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.