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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorALMEIDA, Danilo Candido de-
dc.contributor.authorBASSI, Enio Jose-
dc.contributor.authorAZEVEDO, Hatylas-
dc.contributor.authorANDERSON, Leticia-
dc.contributor.authorORIGASSA, Clarice Silvia Taemi-
dc.contributor.authorCENEDEZE, Marcos Antonio-
dc.contributor.authorANDRADE-OLIVEIRA, Vinicius de-
dc.contributor.authorFELIZARDO, Raphael Jose Ferreira-
dc.contributor.authorSILVA, Reinaldo Correia da-
dc.contributor.authorHIYANE, Meire Ioshie-
dc.contributor.authorSEMEDO, Patricia-
dc.contributor.authorREIS, Marlene Antonia dos-
dc.contributor.authorMOREIRA-FILHO, Carlos Alberto-
dc.contributor.authorVERJOVSKI-ALMEIDA, Sergio-
dc.contributor.authorPACHECO-SILVA, Alvaro-
dc.contributor.authorCAMARA, Niels Olsen Saraiva-
dc.identifier.citationFRONTIERS IN IMMUNOLOGY, v.7, article ID 645, 18p, 2017-
dc.description.abstractMesenchymal stromal cells (MSCs) orchestrate tissue repair by releasing cell-derived microvesicles (MVs), which, presumably by small RNA species, modulate global gene expression. The knowledge of miRNA/mRNA signatures linked to a reparative status may elucidate some of the molecular events associated with MSC protection. Here, we used a model of cisplatin-induced kidney injury (acute kidney injury) to assess how MSCs or MVs could restore tissue function. MSCs and MVs presented similar protective effects, which were evidenced in vivo and in vitro by modulating apoptosis, inflammation, oxidative stress, and a set of prosurvival molecules. In addition, we observed that miRNAs (i.e., miR-880, miR-141, miR-377, and miR-21) were modulated, thereby showing active participation on regenerative process. Subsequently, we identified that MSC regulates a particular miRNA subset which mRNA targets are associated with Wnt/TGF-beta fibrosis, and epithelial-mesenchymal transition signaling pathways. Our results suggest that MSCs release MVs that transcriptionally reprogram injured cells, thereby modulating a specific miRNA-mRNA network.-
dc.description.sponsorshipSao Paulo Research Public Foundation FAPESP-
dc.description.sponsorshipFluid Complex INCT-
dc.description.sponsorshipMS/DECIT/CNPq [07/07193-3, 12/02270-2]-
dc.relation.ispartofFrontiers in Immunology-
dc.subjectmesenchymal stromal cells-
dc.subjectgene expression-
dc.subjectcellular reprograming-
dc.subject.otherextracellular vesicles-
dc.subject.othergenetic information-
dc.titleA Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury-
dc.rights.holderCopyright FRONTIERS MEDIA SA-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Danilo Candido de:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil; Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-, Enio Jose:Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil; Univ Fed Alagoas, Inst Ciencias Biol & Saude, Maceio, Brazil-, Leticia:Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil; Inst Butantan, Sao Paulo, Brazil-, Clarice Silvia Taemi:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-, Marcos Antonio:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-, Vinicius de:Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-, Raphael Jose Ferreira:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-, Reinaldo Correia da:Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-, Meire Ioshie:Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-, Patricia:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-, Marlene Antonia dos:Univ Fed Triangulo Mineiro, Dept Patol, Uberaba, Brazil-, Sergio:Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil; Inst Butantan, Sao Paulo, Brazil-, Alvaro:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil-, Niels Olsen Saraiva:Univ Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil; Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil-
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Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

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