Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/1976
Title: | The minimal inhibitory concentration for sulbactam was not associated with the outcome of infections caused by carbapenem-resistant Acinetobacter sp treated with ampicillin/sulbactam |
Authors: | OLIVEIRA, Maura S. de; COSTA, Silvia Figueiredo; PEDRI, Ewerton de; HEIJDEN, Inneke van der; LEVIN, Anna Sara S. |
Citation: | CLINICS, v.68, n.4, p.569-573, 2013 |
Abstract: | OBJECTIVE: The objective of this study was to evaluate whether the outcomes of carbapenem-resistant Acinetobacter infections treated with ampicillin/sulbactam were associated with the in vitro susceptibility profiles. METHODS: Twenty-two infections were treated with ampicillin/sulbactam. The median treatment duration was 14 days (range: 3-19 days), and the median daily dose was 9 g (range: 1.5-12 g). The median time between Acinetobacter isolation and treatment was 4 days (range: 0-11 days). RESULTS: The sulbactam minimal inhibitory concentration (MIC) ranged from 2.0 to 32.0 mg/L, and the MIC was not associated with patient outcome, as 4 of 5 (80%) patients with a resistant infection (MIC >= 16), 5 of 10 (50%) patients with intermediate isolates (MIC of 8) and only 1 of 7 (14%) patients with susceptible isolates (MIC <= 4) survived hospitalization. CONCLUSION: These findings highlight the need to improve the correlation between in vitro susceptibility tests and clinical outcome. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/Outros Artigos e Materiais de Revistas Científicas - LIM/54 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_OLIVEIRA_The_minimal_inhibitory_concentration_for_sulbactam_was_not_2013.PDF | publishedVersion (English) | 402.8 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.