Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors

Imagem de Miniatura
Arquivos
art_ENGELEN_Reference_intervals_for_common_carotid_intimamedia_thickness_measured_2013.PDF (854.13 KB)
Citações na Scopus
205
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS
Autores
ENGELEN, Lian
FERREIRA, Isabel
STEHOUWER, Coen D.
BOUTOUYRIE, Pierre
LAURENT, Stephane
BOUTOUYRIE, Pierre
LAURENT, Stephane
JOUVEN, Xavier
EMPANA, Jean-Philippe
BOZEC, Erwan
Citação
EUROPEAN HEART JOURNAL, v.34, n.30, p.2368-0, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aims Common carotid artery intima-media thickness (CCIMT) is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease (CVD). The interpretation of CCIMT values has been hampered by the absence of reference values, however. We therefore aimed to establish reference intervals of CCIMT, obtained using the probably most accurate method at present (i.e. echotracking), to help interpretation of these measures. Methods and results We combined CCIMT data obtained by echotracking on 24 871 individuals (53 men; age range 15-101 years) from 24 research centres worldwide. Individuals without CVD, cardiovascular risk factors (CV-RFs), and BP-, lipid-, and/or glucose-lowering medication constituted a healthy sub-population (n = 4234) used to establish sex-specific equations for percentiles of CCIMT across age. With these equations, we generated CCIMT Z-scores in different reference sub-populations, thereby allowing for a standardized comparison between observed and predicted (normal) values from individuals of the same age and sex. In the sub-population without CVD and treatment (n = 14 609), and in men and women, respectively, CCIMT Z-scores were independently associated with systolic blood pressure [standardized s 0.19 (95 CI: 0.16-0.22) and 0.18 (0.15-0.21)], smoking [0.25 (0.19-0.31) and 0.11 (0.04-0.18)], diabetes [0.19 (0.05-0.33) and 0.19 (0.02-0.36)], total-to-HDL cholesterol ratio [0.07 (0.04-0.10) and 0.05 (0.02-0.09)], and body mass index [0.14 (0.12-0.17) and 0.07 (0.04-0.10)]. Conclusion We estimated age- and sex-specific percentiles of CCIMT in a healthy population and assessed the association of CV-RFs with CCIMT Z-scores, which enables comparison of IMT values for (patient) groups with different cardiovascular risk profiles, helping interpretation of such measures obtained both in research and clinical settings.
Palavras-chave
Ageing, Atherosclerois, Carotid intima-media thickness, Echotracking, Reference intervals, Risk factors
URI
https://observatorio.fm.usp.br/handle/OPI/21563
Referências
  1. Baldassarre D, 2010, EUR HEART J, V31, P614, DOI 10.1093/eurheartj/ehp496
  2. Bianchini E, 2010, J ULTRAS MED, V29, P1169
  3. Bots ML, 2005, STROKE, V36, P762, DOI 10.1161/01.STR.0000158924.71069.94
  4. Bots ML, 1997, STROKE, V28, P2442
  5. Bots ML, 2003, STROKE, V34, P2985, DOI 10.1161/01.STR.0000102044.27905.B5
  6. Brands P J, 1999, Eur J Ultrasound, V9, P257, DOI 10.1016/S0929-8266(99)00033-6
  7. Chambless LE, 2002, AM J EPIDEMIOL, V155, P38, DOI 10.1093/aje/155.1.38
  8. Ciccone MM, 2011, EUR J CARDIOV PREV R, V18, P650, DOI 10.1177/1741826711398841
  9. Conroy RM, 2003, EUR HEART J, V24, P987, DOI 10.1016/S0195-668X(03)00114-3
  10. Dahabreh IJ, 2011, JAMA-J AM MED ASSOC, V305, P822, DOI 10.1001/jama.2011.163
  11. Den Ruijter HM, 2012, JAMA-J AM MED ASSOC, V308, P796, DOI 10.1001/jama.2012.9630
  12. Espeland MA, 1999, STROKE, V30, P1047
  13. Geerts CC, 2012, ANN MED, V44, P350, DOI 10.3109/07853890.2011.558520
  14. GIRERD X, 1994, J VASC RES, V31, P114
  15. Girerd X, 1996, INTIMA MEDIA THICKNE, P45
  16. Held C, 2001, EUR HEART J, V22, P62, DOI 10.1053/euhj.1999.2006
  17. Hoeks APG, 1997, ULTRASOUND MED BIOL, V23, P1017, DOI 10.1016/S0301-5629(97)00119-1
  18. HOWARD G, 1993, STROKE, V24, P1297
  19. Huxley R, 2006, BRIT MED J, V332, P73, DOI 10.1136/bmj.38678.389583.7C
  20. Huxley RR, 2011, LANCET, V378, P1297, DOI 10.1016/S0140-6736(11)60781-2
  21. Janssen KJM, 2010, J CLIN EPIDEMIOL, V63, P721, DOI 10.1016/j.jclinepi.2009.12.008
  22. Kizer JR, 2011, AM J EPIDEMIOL, V173, P10, DOI 10.1093/aje/kwq311
  23. Koskinen J, 2010, CIRCULATION, V121, P392, DOI 10.1161/CIRCULATIONAHA.109.894584
  24. Li C, 2006, INT J OBESITY, V30, P1775, DOI 10.1038/sj.ijo.0803339
  25. Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
  26. Mancia G, 2007, EUR HEART J, V28, P1462, DOI 10.1093/eurheartj/ehm236
  27. Meinders JM, 2003, AM J PHYSIOL-HEART C, V285, pH384, DOI 10.1152/ajpheart.00729.2002
  28. Peters SAE, 2011, EUR J CARDIOV PREV R, V18, P167, DOI 10.1177/1741826710389400
  29. PIGNOLI P, 1986, CIRCULATION, V74, P1399
  30. Royston P, 1998, J R STAT SOC A STAT, V161, P79, DOI 10.1111/1467-985X.00091
  31. Sarwar N, 2010, LANCET, V375, P2215
  32. Schouten F, 2011, AM J CLIN NUTR, V94, P40, DOI 10.3945/ajcn.111.013532
  33. Sinning C, 2011, AM J CARDIOL, V107, P1841, DOI 10.1016/j.amjcard.2011.02.318
  34. Stein JH, 2008, J AM SOC ECHOCARDIOG, V21, P93, DOI 10.1016/j.echo.2007.11.011
  35. Sterne JAC, 2009, BRIT MED J, V339, DOI 10.1136/bmj.b2393
  36. Touboul PJ, 2007, CEREBROVASC DIS, V23, P75, DOI 10.1159/000097034
  37. Tzou Wendy S, 2007, Prev Cardiol, V10, P181, DOI 10.1111/j.1520-037X.2007.06450.x
  38. Urbina EM, 2009, HYPERTENSION, V54, P919, DOI 10.1161/HYPERTENSIONAHA.109.192639
  39. Vasan RS, 2001, NEW ENGL J MED, V345, P1291, DOI 10.1056/NEJMoa003417
  40. World Health Organization, 1999, WHONCDNCS992 1
  41. WHO, 2000, WHO TECHN REP SER, V894
  42. Wilson PWF, 1998, CIRCULATION, V97, P1837
  43. Wright E, 1997, STATA TECH B, V38, P4
  44. Youn YJ, 2011, J KOREAN MED SCI, V26, P365, DOI 10.3346/jkms.2011.26.3.365
  45. Zureik M, 2002, J HYPERTENS, V20, P85, DOI 10.1097/00004872-200201000-00013

Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - ODS/03