Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

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art_SARTORI_Association_between_Diastolic_Dysfunction_with_Inflammation_and_Oxidative_2017.PDF (977.42 KB)
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
CONTI, Filipe F.
DIAS, Danielle da Silva
MACHI, Jacqueline F.
PALOMINO, Zaira
CASARINI, Dulce E.
RODRIGUES, Bruno
ANGELIS, Kytia de
Citação
FRONTIERS IN PHYSIOLOGY, v.8, article ID 572, 10p, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stressmarkers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress. Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals.
Palavras-chave
obesity, cardiac dysfunction, autonomic, inflammation, female
URI
https://observatorio.fm.usp.br/handle/OPI/22114
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/59
Artigos e Materiais de Revistas Científicas - ODS/03