Transcranial sonography findings in spinocerebellar ataxia type 3 (Machado-Joseph disease): A cross-sectional study

Imagem de Miniatura
Arquivos
art_PEDROSO_Transcranial_sonography_findings_in_spinocerebellar_ataxia_type_3_2011.PDF (335.26 KB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER IRELAND LTD
Autores
PEDROSO, Jose Luiz
FELICIO, Andre Carvalho
BRAGA-NETO, Pedro
BARSOTTINI, Orlando Graziani
Citação
NEUROSCIENCE LETTERS, v.504, n.2, p.98-101, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Few studies on transcranial brain sonography have been performed in hereditary and non-hereditary ataxias. The objective of the present study was to report transcranial brain sonography findings in a sample of clinically and molecularly proven Machado-Joseph disease patients and to compare these data against those of an age- and gender-matched control group. A cross-sectional study on transcranial brain sonography was conducted in 30 Machado-Joseph disease patients. Transcranial brain sonography was performed by an experienced sonographer blinded to the clinical, genetic, and neuroimaging data. The results were compared with those of a control group of 44 healthy subjects matched for age and gender. The sonographic findings were also correlated with clinical features and genetic data in Machado-Joseph disease group. A significantly higher frequency of substantia nigra and lenticular nucleus hyperechogenicity was found in the Machado-Joseph disease group compared to an age- and gender-matched healthy control group (p < 0.001). The substantia nigra echogenic area proved to be the best predictor for differentiating cases from controls. Third and lateral ventricles were significantly larger in the Machado-Joseph disease patients than in the control subjects. No significant correlations were found between transcranial brain sonography findings and Machado-Joseph disease demographic/clinical data. Transcranial brain sonography findings in Machado-Joseph disease patients differed significantly to those in age- and gender-matched controls. Substantia nigra hyperechogenicity occurred frequently in Machado-Joseph disease patients and was found to be the best predictor for differentiating cases from controls. Additionally, this data describes the occurrence of brain atrophy in Machado-Joseph disease group.
Palavras-chave
Spinocerebellar ataxia type 3, Machado-Joseph disease, Transcranial sonography, Substantia nigra hyperechogenicity, Brain ultrasound
URI
https://observatorio.fm.usp.br/handle/OPI/23152
Referências
  1. Schols L, 2004, LANCET NEUROL, V3, P291, DOI 10.1016/S1474-4422(04)00737-9
  2. Riess O, 2008, CEREBELLUM, V7, P125, DOI 10.1007/s12311-008-0013-4
  3. Stiasny-Kolster K, 2007, MOVEMENT DISORD, V22, P2386, DOI 10.1002/mds.21740
  4. Berg D, 2005, MOVEMENT DISORD, V20, P383, DOI 10.1002/mds.20311
  5. Braga-Neto P, 2010, ARQ NEURO-PSIQUIAT, V68, P228, DOI 10.1590/S0004-282X2010000200014
  6. Yen TC, 2000, J NUCL MED, V41, P994
  7. Walter U, 2007, ARCH NEUROL-CHICAGO, V64, P1635, DOI 10.1001/archneur.64.11.1635
  8. Gaenslen A, 2008, LANCET NEUROL, V7, P417, DOI 10.1016/S1474-4422(08)70067-X
  9. Berg D, 2008, LANCET NEUROL, V7, P1044, DOI 10.1016/S1474-4422(08)70239-4
  10. BECKER G, 1995, NEUROLOGY, V45, P182
  11. Kagi G, 2010, J NEUROL NEUROSUR PS, V81, P5, DOI 10.1136/jnnp.2008.157370
  12. D'Abreu A, 2010, PARKINSONISM RELAT D, V16, P2, DOI 10.1016/j.parkreldis.2009.08.012
  13. van Gaalen J, 2011, MOVEMENT DISORD, V26, P792, DOI 10.1002/mds.23584
  14. Berg D, 2002, ARCH NEUROL-CHICAGO, V59, P999, DOI 10.1001/archneur.59.6.999
  15. Walter U, 2007, ULTRASOUND MED BIOL, V33, P15, DOI 10.1016/j.ultrasmedbio.2006.07.021
  16. Godau J, 2010, NEUROIMAG CLIN N AM, V20, P87, DOI 10.1016/j.nic.2009.08.003
  17. Rub U, 2008, CURR OPIN NEUROL, V21, P111, DOI 10.1097/WCO.0b013e3282f7673d
  18. Masuko AH, 2008, ARQ NEURO-PSIQUIAT, V66, P832, DOI 10.1590/S0004-282X2008000600011
  19. Barsottini OGP, 2011, CLIN NEUROL NEUROSUR, V113, P404, DOI 10.1016/j.clineuro.2010.11.015
  20. Berg D, 2001, BIOL PSYCHIAT, V50, P463, DOI 10.1016/S0006-3223(01)01190-8
  21. Bor-Seng-Shu E, 2010, ACTA NEUROCHIR, V152, P2085, DOI 10.1007/s00701-010-0736-0
  22. Carbon M, 2006, J NEUROL SCI, V248, P72, DOI 10.1016/j.jns.2006.05.005
  23. Felicio AC, 2010, J NEUROL SCI, V291, P64, DOI 10.1016/j.jns.2009.12.024
  24. Gaenslen A, 2010, INT REV NEUROBIOL, V90, P179, DOI 10.1016/S0074-7742(10)90013-5
  25. Jardim LB, 2001, ACTA NEUROL SCAND, V104, P224, DOI 10.1034/j.1600-0404.2001.00020.x
  26. Krogias C, 2010, INT REV NEUROBIOL, V90, P217, DOI 10.1016/S0074-7742(10)90016-0
  27. Lu CS, 2004, PARKINSONISM RELAT D, V10, P369, DOI 10.1016/j.parkreldis.2004.03.009
  28. Mijajlovic M, 2008, J NEUROL, V255, P1164, DOI [10.1007/s00415-008-0862-2, 10.1007/500415-008-0862-2]
  29. Postert T, 1999, J NEUROL NEUROSUR PS, V67, P457, DOI 10.1136/jnnp.67.4.457
  30. Postert T., 2004, J NEURO ONCOL S, V68, P123
  31. Ricciardi MC, 2010, J ULTRAS MED, V29, P1143
  32. Roos RAC, 2010, ORPHANET J RARE DIS, V5, DOI 10.1186/1750-1172-5-40
  33. Walter U, 2007, MOVEMENT DISORD, V22, P48, DOI 10.1002/mds.21197
  34. Wolters A, 2005, KLIN NEUROPHYSIOL, V36, P9, DOI 10.1055/s-2004-834704

Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/26