Development of human minor salivary glands: expression of mucins according to stage of morphogenesis

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art_TESHIMA_Development_of_human_minor_salivary_glands_expression_of_2011.PDF (2.2 MB)
Citações na Scopus
19
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
TESHIMA, Tathyane H. N.
IANEZ, Renata F.
COUTINHO-CAMILLO, Claudia M.
BUIM, Marcilei E.
SOARES, Fernando A.
Citação
JOURNAL OF ANATOMY, v.219, n.3, p.410-417, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The formation of salivary glands entails the proliferation of epithelial cells from the stomatodeum into the underlying ectomesenchyme, culminating in a complex network of ducts and acinar bulbs. The extent to which mucins regulate this process is unknown, but they appear to mediate luminal space formation and maturation. Our aim was to examine mucin expression patterns during the morphogenesis of human salivary glands. Mucin expression - MUC1, 2, 3, 4, 5AC, 5B, 6, and 16 - was analyzed in specimens of developing human salivary glands, obtained from fetuses at 4-24 weeks' gestation, and fully developed salivary glands by immunohistochemistry. Expression patterns were analyzed qualitatively according to the development stage of the salivary glands. Mucins 1, 3, 4, 5B, and 16 were expressed during salivary gland development - being stronger in all ductal segments by the final phases of branching morphogenesis and in mature glands. Acinar cells were negative for most mucins, including MUC1 in mature salivary glands. Mucins 2, 5AC, and 6 were not expressed. Mucins MUC1, 3, 4, 5B, and 16 are expressed in developing human salivary glands and in mature glands, suggesting important roles in the maturation and maintenance of the ductal network.
Palavras-chave
branching morphogenesis, human salivary glands, mucin
URI
https://observatorio.fm.usp.br/handle/OPI/24049
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/06