Serological and molecular markers of hepatitis E virus infection in HIV-infected patients in Brazil

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art_FERREIRA_Serological_and_molecular_markers_of_hepatitis_E_virus_2018.PDF (537.72 KB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER WIEN
Autores
SALLES, N. A.
Citação
ARCHIVES OF VIROLOGY, v.163, n.1, p.43-49, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
In Brazil, the circulation of hepatitis E virus (HEV) has been demonstrated in distinct groups of individuals and some animals, but its prevalence among individuals with human immunodeficiency virus (HIV) infection is unknown. This study aimed to assess the frequency of serological and molecular HEV markers in individuals infected with HIV from So Paulo, Brazil. Serum and plasma samples of 354 HIV-infected patients collected between 2007 and 2013 were included. All samples were tested for anti-HEV IgG and IgM antibodies and HEV RNA. Anti-HEV IgG and IgM antibodies were detected in 10.7% (38/354) and 1.4% (5/354) of the samples, respectively. Both antibodies were detected simultaneously in only two samples. HEV RNA was not detected in any sample. There was no significant correlation of anti-HEV serological status (positivity to anti-HEV IgG and/or IgM) with sex, age, CD4(+) T cell count, HIV viral load, antiretroviral therapy, liver enzyme levels, or coinfection with hepatitis B virus and/or hepatitis C virus. Our study provides serological evidence of past and recent HEV infections in HIV-infected patients from So Paulo, Brazil. However, the occurrence of ongoing HEV infection appears be a rare event in this population.
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URI
https://observatorio.fm.usp.br/handle/OPI/24918
Referências
  1. Assis Sandra Breder, 2002, Rev. Soc. Bras. Med. Trop., V35, P155, DOI 10.1590/S0037-86822002000200005
  2. BALAYAN MS, 1983, INTERVIROLOGY, V20, P23, DOI 10.1159/000149370
  3. Balayan MS, 1997, J VIRAL HEPATITIS, V4, P279, DOI 10.1046/j.1365-2893.1997.00050.x
  4. Bortoliero André Luiz, 2006, Rev. Inst. Med. trop. S. Paulo, V48, P87, DOI 10.1590/S0036-46652006000200006
  5. Colson P, 2009, J CLIN VIROL, V45, P269, DOI 10.1016/j.jcv.2009.06.002
  6. Crum-Cianflone NF, 2012, EMERG INFECT DIS, V18, P502, DOI 10.3201/eid1803.111278
  7. Lana MVD, 2014, TROP ANIM HEALTH PRO, V46, P399, DOI 10.1007/s11250-013-0503-3
  8. Dalton HR, 2016, DIGEST DIS, V34, P308, DOI 10.1159/000444468
  9. Dalton HR, 2014, FUTURE MICROBIOL, V9, P1361, DOI 10.2217/fmb.14.89
  10. Dalton HR, 2009, NEW ENGL J MED, V361, P1025, DOI 10.1056/NEJMc0903778
  11. de Freitas NR, 2016, MEM I OSWALDO CRUZ, V111, P692, DOI 10.1590/0074-02760160256
  12. Debes JD, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160082
  13. Debes JD, 2016, J CLIN VIROL, V80, P102, DOI 10.1016/j.jcv.2016.05.006
  14. dos Santos DCM, 2002, MEM I OSWALDO CRUZ, V97, P637, DOI 10.1590/S0074-02762002000500007
  15. Fainboim H, 1999, J VIRAL HEPATITIS, V6, P53, DOI 10.1046/j.1365-2893.1999.t01-1-6120135.x
  16. Feldt T, 2013, J CLIN VIROL, V58, P18, DOI 10.1016/j.jcv.2013.05.004
  17. Geng YS, 2014, HEPAT MON, V14, DOI 10.5812/hepatmon.15618
  18. Gerolami R, 2008, NEW ENGL J MED, V358, P859, DOI 10.1056/NEJMc0708687
  19. Goncales NSL, 2000, CLIN DIAGN LAB IMMUN, V7, P813, DOI 10.1128/CDLI.7.5.813-816.2000
  20. Guimaraes FR, 2005, BRAZ J MICROBIOL, V36, P223, DOI 10.1590/S1517-83822005000300004
  21. Haagsma EB, 2008, LIVER TRANSPLANT, V14, P547, DOI 10.1002/lt.21480
  22. HARTL J, 2016, VIRUSES-BASEL, V8, DOI 10.3390/V8110299
  23. Hartl J, 2016, VIRUSES-BASEL, V8, DOI 10.3390/v8080211
  24. Heldt FH, 2016, FOOD ENVIRON VIROL, V8, P200, DOI 10.1007/s12560-016-9243-7
  25. Hering T, 2014, J MED VIROL, V86, P948, DOI 10.1002/jmv.23915
  26. Ingiliz P, 2016, CLIN RES HEPATOL GAS, V40, pE23, DOI 10.1016/j.clinre.2016.01.005
  27. Jothikumar N, 2006, J VIROL METHODS, V131, P65, DOI [10.1016/j.jviromet.2005.07.004, 10.1016/j.viromet.2005.07.004]
  28. Kaba M, 2011, J MED VIROL, V83, P1704, DOI 10.1002/jmv.22177
  29. Kamar N, 2008, NEW ENGL J MED, V358, P811, DOI 10.1056/NEJMoa0706992
  30. Kamar N, 2014, CLIN MICROBIOL REV, V27, P116, DOI 10.1128/CMR.00057-13
  31. Kamar N, 2012, LANCET, V379, P2477, DOI 10.1016/S0140-6736(11)61849-7
  32. Keane FE, 2012, HIV MED, V13, P83, DOI 10.1111/j.1468-1293.2011.00942.x
  33. Kenfak-Foguena A, 2011, EMERG INFECT DIS, V17, P1074, DOI [10.3201/eid1706.101067, 10.3201/eid/1706.101067]
  34. Khudyakov Y, 2011, VIRUS RES, V161, P84, DOI 10.1016/j.virusres.2011.06.006
  35. Koning L, 2013, J HEART LUNG TRANSPL, V32, P78, DOI 10.1016/j.healun.2012.10.008
  36. Kuniholm MH, 2016, HEPATOLOGY, V63, P712, DOI 10.1002/hep.28384
  37. Lee GH, 2016, GASTROENTEROLOGY, V150, P355, DOI 10.1053/j.gastro.2015.10.048
  38. dos Santos DRL, 2009, VET J, V182, P474, DOI 10.1016/j.tvjl.2008.08.001
  39. Lyra AC, 2005, BRAZ J MED BIOL RES, V38, P767, DOI 10.1590/S0100-879X2005000500015
  40. Martins RMB, 2014, J CLIN VIROL, V59, P188, DOI 10.1016/j.jcv.2014.01.002
  41. Maylin S, 2012, J CLIN VIROL, V53, P346, DOI 10.1016/j.jcv.2012.01.001
  42. Neukam K, 2013, CLIN INFECT DIS, V57, P465, DOI 10.1093/cid/cit224
  43. Paiva HH, 2007, BRAZ J MICROBIOL, V38, P693, DOI 10.1590/S1517-83822007000400020
  44. Parana R, 1997, AM J TROP MED HYG, V57, P60, DOI 10.4269/ajtmh.1997.57.60
  45. Passos-Castilho AM, 2017, BRAZ J INFECT DIS, V21, P535, DOI 10.1016/j.bjid.2017.05.004
  46. Passos-Castilho AM, 2016, J MED VIROL, V88, P361, DOI 10.1002/jmv.24336
  47. Passos-Castilho AM, 2014, J CLIN MICROBIOL, V52, P4425, DOI 10.1128/JCM.02286-14
  48. Pischke S, 2010, LIVER TRANSPLANT, V16, P74, DOI 10.1002/lt.21958
  49. Politou M, 2015, J MED VIROL, V87, P1517, DOI 10.1002/jmv.24214
  50. Ramezani A, 2013, INT J STD AIDS, V24, P769, DOI 10.1177/0956462413484457
  51. Rivero-Juarez A, 2015, J INFECTION, V70, P680, DOI 10.1016/j.jinf.2014.11.010
  52. Rode OD, 2014, EUR J CLIN MICROBIOL, V33, P2231, DOI 10.1007/s10096-014-2187-7
  53. Scotto G, 2015, INFECT DIS-NOR, V47, P707, DOI 10.3109/23744235.2015.1049658
  54. Singh GJ, 2011, HIV MED, V12, P44
  55. Smith DB, 2014, J GEN VIROL, V95, P2223, DOI 10.1099/vir.0.068429-0
  56. Souto FJD, 1997, AM J TROP MED HYG, V57, P149, DOI 10.4269/ajtmh.1997.57.149
  57. de Souza AJS, 2012, COMP IMMUNOL MICROB, V35, P477, DOI 10.1016/j.cimid.2012.04.004
  58. Tamura A, 2007, HEPATOL RES, V37, P113, DOI 10.1111/j.1872-034X.2007.00024.x
  59. Trinta KS, 2001, MEM I OSWALDO CRUZ, V96, P25, DOI 10.1590/S0074-02762001000100004
  60. Vitral CL, 2005, MEM I OSWALDO CRUZ, V100, P117, DOI 10.1590/S0074-02762005000200003
  61. Wenzel JJ, 2013, J INFECT DIS, V207, P497, DOI 10.1093/infdis/jis688

Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - ODS/03