Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis

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art_PASCHOAL_Relationship_between_endothelial_nitric_oxide_synthase_eNOS_and_2018.PDF (515.55 KB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
YAMAKI, Vitor Nagai
TEIXEIRA, Renan Kleber Costa
JONG-A-LIEM, Glaucia Suzanna
YAMADA, Elizabeth Sumi
RIBEIRO-DOS-SANTOS, Andrea
Citação
NEUROSURGICAL REVIEW, v.41, n.1, p.87-94, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The aneurysmal subarachnoid hemorrhage is a major public health problem described as a sudden drastic event with no warning symptoms and high morbidity and mortality rates. The role of the endothelial isoform of nitric oxide synthase gene polymorphism in intracranial aneurysms (IAs) is still a matter of controversy with divergent findings among European, American, and Asian populations. Our study purposed to test the association between intracranial aneurysms formation and nitric oxide gene polymorphisms through a systematic review and meta-analysis. Systematic search on Medline, Lilacs, and EMBASE was performed. The primary search resulted in 139 papers, out of which 9 met our inclusion criteria after a full text analysis. The dominant T786C model found a significant association with IA (OR 1.22, 95 % CI 1.04-1.44, p = 0.01), so did studies of the recessive T786C model (OR 0.37, 95 % CI 0.30-0.45, p < 0.0001) but with opposite effect. Our findings support the presence of the T786C polymorphism as a predictor for the development of intracranial aneurysm in the cerebral vascular system. More studies are necessary in order to elucidate the pathways of the endothelial nitric oxide synthase (eNOS) in cerebrovascular diseases and in defining how different allelic combinations of the eNOS gene single-nucleotide polymorphism (SNP) could favor this pathological process.
Palavras-chave
Endothelial nitric oxide synthase, Genetic polymorphisms, Intracranial aneurysms, Meta-analysis, Subarachnoid hemorrhage
URI
https://observatorio.fm.usp.br/handle/OPI/24923
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/26
Artigos e Materiais de Revistas Científicas - ODS/03