QUANTIFICATION OF LEFT VENTRICULAR MYOCARDIAL COLLAGEN SYSTEM IN CHILDREN, YOUNG ADULTS, AND THE ELDERLY

Imagem de Miniatura
Arquivos
art_RODRIGUES_QUANTIFICATION_OF_LEFT_VENTRICULAR_MYOCARDIAL_COLLAGEN_SYSTEM_IN_2012.PDF (547.8 KB)
Citações na Scopus
35
Tipo de produção
article
Data de publicação
2012
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MEDICINA (BUENOS AIRES)
Autores
MENDES, Andrea Bogoslavsky Levy
FERRO, Marcelo
SOUZA, Monica Rodrigues De
ARAUJO, Rubens Correa
SOUZA, Romeu Rodrigues De
Citação
MEDICINA-BUENOS AIRES, v.72, n.3, p.216-220, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Studies on the collagen system of the human myocardium are still limited compared to those on small laboratory animals. The aim of this work was to observe the collagen tissue of the myocardium of the human heart as a function of age. The types of collagen, as well as the density of collagen tissue and the diameter of collagen fibrils, were examined. Fragments of the left ventricular wall from 15 hearts, 5 from children, 5 from young adults, and 5 from elderly individuals, were analyzed by using the Picrosirius-polarization method and by transmission electron microscopy (TEM). The results showed the presence of collagen type III and collagen type I, both in the endomysium and perimysium of the 3 groups studied. Measurements of collagen content in myocardial tissue displayed that both endomysial and perimysial collagen increase in number and thickness in the adult and elderly. These histochemical results coincided with the observations obtained with the electron microscope in showing an increase in the number of collagen fibrils with a large diameter in the adult and elderly hearts. The present results on cardiac collagen may be important for assessing the pathogenesis of several cardiopathies in the hearts of children, young adults, and the elderly.
Palavras-chave
collagen fibrils, morphometry, human heart, children, young adult, elderly
URI
https://observatorio.fm.usp.br/handle/OPI/2583
Referências
  1. Akamatsu FE, 1999, MECH AGEING DEV, V109, P153, DOI 10.1016/S0047-6374(99)00023-8
  2. Annoni G, 1998, MECH AGEING DEV, V101, P57, DOI 10.1016/S0047-6374(97)00165-6
  3. BERKOVITZ BKB, 1993, BRIT HEART J, V69, P246
  4. BORG TK, 1981, LAB INVEST, V44, P49
  5. Bos HS, 2004, PACE, V27, P1451, DOI 10.1111/j.1540-8159.2004.00655.x
  6. Brilla CG, 2000, HERZ, V25, P299, DOI 10.1007/s000590050024
  7. BURTON CR, 1954, CAN MED ASSOC J, V70, P404
  8. CARVER W, 1991, CIRC RES, V69, P116
  9. CAULFIELD JB, 1988, AM J PATHOL, V131, P199
  10. CLAUSEN B, 1963, LAB INVEST, V12, P538
  11. Debessa CRG, 2001, MECH AGEING DEV, V122, P1049
  12. de Souza RR, 2002, BIOGERONTOLOGY, V3, P325, DOI 10.1023/A:1021312027486
  13. EGHBALI M, 1989, CARDIOVASC RES, V23, P723, DOI 10.1093/cvr/23.8.723
  14. EGHBALI M, 1988, J MOL CELL CARDIOL, V20, P267, DOI 10.1016/S0022-2828(88)80059-2
  15. Eghbali M., 1990, HEART FAILURE, V6, P125
  16. Fielitz J, 2001, J AM COLL CARDIOL, V37, P1443, DOI 10.1016/S0735-1097(01)01170-6
  17. Goldsmith P, 2007, PHARMACOLOGY, V79, P250, DOI 10.1159/000102061
  18. Gomes WJ, 1997, EUR J CARDIO-THORAC, V12, P666, DOI 10.1016/S1010-7940(97)00219-4
  19. IGNOTZ RA, 1986, J BIOL CHEM, V261, P4337
  20. JUNQUEIRA LCU, 1978, ARCH HISTOL JAPON, V41, P267
  21. JUNQUEIRA LCU, 1979, HISTOCHEM J, V11, P447, DOI 10.1007/BF01002772
  22. Kanekar S, 2000, CELL ADHES COMMUN, V7, P513, DOI 10.3109/15419060009040308
  23. Kuwahara F, 2002, CIRCULATION, V106, P130, DOI 10.1161/01.CIR.0000020689.12472.E0
  24. Lijnen PJ, 2000, MOL GENET METAB, V71, P418, DOI 10.1006/mgme.2000.3032
  25. MEDUGORAC I, 1980, CARDIOVASC RES, V14, P551, DOI 10.1093/cvr/14.9.551
  26. MICHEL JB, 1986, BASIC RES CARDIOL, V81, P142, DOI 10.1007/BF01907379
  27. OLIVETTI G, 1991, CIRC RES, V68, P1560
  28. Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
  29. REYNOLDS J. L., 1963, JOUR LOUISIANA STATE MED SOC, V115, P196
  30. ROBINSON TF, 1983, LAB INVEST, V49, P482
  31. Rocic P, 2005, CIRC RES, V97, P850, DOI 10.1161/01.RES.0000190403.87462.bf
  32. Rubinstein Mauricio, 2007, Int Braz J Urol, V33, P33, DOI 10.1590/S1677-55382007000100006
  33. Susman EJ, 2002, J ADOLESCENT HEALTH, V31, P171, DOI 10.1016/S1054-139X(02)00487-1
  34. Ushiki T, 2002, ARCH HISTOL CYTOL, V65, P109, DOI 10.1679/aohc.65.109
  35. WATSON ML, 1958, J BIOPHYS BIOCHEM CY, V4, P727, DOI 10.1083/jcb.4.6.727
  36. Werzar F., 1964, GERONTOLOGIA BASEL, V9, P209
  37. Werzar F., 1969, GERONTOLOGIA, V15, P233
  38. WHITTAKER P, 1994, BASIC RES CARDIOL, V89, P397, DOI 10.1007/BF00788278
  39. YOUNG LH, 1994, AM J PHYSIOL, V267, pE337
  40. Zannad F, 2000, CIRCULATION, V102, P2700
  41. Zhang H, 2007, MOL CELL PROTEOMICS, V6, P64, DOI 10.1074/mcp.M600160-MCP200

Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros