Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients

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art_RIBEIRO_Increase_of_10_in_the_Rate_of_Adverse_2018.PDF (325.9 KB)
Citações na Scopus
13
Tipo de produção
article
Data de publicação
2018
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
RIBEIRO, Marisa Rosimeire
Citação
CLINICS, v.73, article ID UNSP e185, 6p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization. The patients were visited every other day, and medical records were reviewed by the investigators to detect adverse drug reactions. RESULTS: There were a total of 94 adverse drug reactions in 75 patients. Most reactions were predictable and of moderate severity. The incidence of adverse drug reactions was 16.2%, and the incidence varied, according to the medical specialty; it was higher in Internal Medicine (30%). Antibiotics were the most commonly involved medication. Chronic renal failure, longer hospital stay, greater number of diagnoses and greater number of medications upon admission were risk factors. For each medication introduced during hospitalization, there was a 10% increase in the rate of adverse drug reaction. In the present study, the probability of observing an adverse drug reaction was 1 in 104 patients per day. CONCLUSIONS: Adverse drug reactions are frequent and potentially serious and should be better monitored in patients with chronic renal failure or prolonged hospitalization and especially in those on 'polypharmacy' regimens. The rational use of medications plays an important role in preventing adverse drug reactions.
Palavras-chave
Adverse Drug Reactions, Hypersensitivity Reactions, In-patients, Incidence, Risk factors
URI
https://observatorio.fm.usp.br/handle/OPI/26253
Referências
  1. Agondi RC, 2010, ALLERGY, V65, P510, DOI 10.1111/j.1398-9995.2009.02211.x
  2. Lobo MGAD, 2013, BMC PHARMACOL TOXICO, V14, DOI 10.1186/2050-6511-14-5
  3. Arulmani R, 2008, BRIT J CLIN PHARMACO, V65, P210, DOI 10.1111/j.1365-2125.2007.02993.x
  4. Asher I, 2008, NEW ZEAL MED J, V121, P117
  5. Noblat ACB, 2011, REV ASSOC MED BRAS, V57, P42, DOI 10.1590/S0104-42302011000100014
  6. Davies EC, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004439
  7. Demoly P, 1999, ALLERGY, V54, P999, DOI 10.1034/j.1398-9995.1999.00247.x
  8. Demoly P, 2001, REV PORT IMUNOALERG, V8, P231
  9. Fattinger K, 2000, BRIT J CLIN PHARMACO, V49, P158, DOI 10.1046/j.1365-2125.2000.00132.x
  10. Global Initiative for Asthma (GINA), 2012, GLOB STRAT ASTHM MAN
  11. Gomes ER, 2005, CURR OPIN ALLERGY CL, V5, P309, DOI 10.1097/01.all.0000173785.81024.33
  12. HARTWIG SC, 1992, AM J HOSP PHARM, V49, P2229
  13. Hernandez-Salazar A, 2006, ARCH MED RES, V37, P899, DOI 10.1016/j.arcmed.2006.03.010
  14. Hosmer D, 2000, APPL LOGISTIC REGRES, P320
  15. Johansson SGO, 2004, J ALLERGY CLIN IMMUN, V113, P832, DOI 10.1016/j.jaci.2003.12.591
  16. Kane-Gill SL, 2012, DRUG SAFETY, V35, P645, DOI 10.2165/11599730-000000000-00000
  17. Khan LM, 2012, SAUDI MED J, V33, P863
  18. Khan LM, 2013, EUR J CLIN PHARMACOL, V69, P1985, DOI 10.1007/s00228-013-1563-z
  19. Kirkwood B, 2006, ESSENTIAL MED STAT
  20. Krahenbuhl-Melcher A, 2007, DRUG SAFETY, V30, P379
  21. Kvasz M, 2000, MedGenMed, V2, pE3
  22. Lazarou J, 1998, JAMA-J AM MED ASSOC, V279, P1200, DOI 10.1001/jama.279.15.1200
  23. NARANJO CA, 1981, CLIN PHARMACOL THER, V30, P239, DOI 10.1038/clpt.1981.154
  24. Neter J., 1996, APPL LINEAR STAT MOD
  25. Pirmohamed M, 2004, BRIT MED J, V329, P15, DOI 10.1136/bmj.329.7456.15
  26. Pourseyed S, 2009, PHARMACOEPIDEM DR S, V18, P104, DOI 10.1002/pds.1663
  27. Ramesh M, 2003, PHARMACOEPIDEM DR S, V12, P687, DOI 10.1002/pds.871
  28. Rawlins M, 1977, TXB ADVERSE DRUG REA, P10
  29. Munoz-Torrero JFS, 2010, EUR J CLIN PHARMACOL, V66, P1257, DOI 10.1007/s00228-010-0866-6
  30. Suh DC, 2000, ANN PHARMACOTHER, V34, P1373
  31. World Health Organization, 1972, 498 WHO

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Artigos e Materiais de Revistas Científicas - FM/MCM
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