https://observatorio.fm.usp.br/handle/OPI/29884
Title: | Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis: Long-Term Follow-Up Study |
Authors: | HOFLING, Danilo Bianchini; CHAVANTES, Maria Cristina; BUCHPIGUEL, Carlos Alberto; CERRI, Giovanni Guido; MARUI, Suemi; CARNEIRO, Paulo Campos; CHAMMAS, Maria Cristina |
Citation: | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, article ID 8387530, 9p, 2018 |
Abstract: | Introduction. A randomized clinical trial (RCT) was performed to evaluate the efficacy of low-level laser therapy (LLLT) for hypothyroidism induced by chronic autoimmune thyroiditis (CAT). Objective. The objective was to assess the safety and actions of LLLT 6 years after completion of the RCT. Materials and Methods. Forty-three participants were invited to participate in this study 6 years after completion of the RCT. Twenty-five were subjected to LLLT (group L), and 18 were subjected to placebo (group P). Primary outcome measure: frequency of thyroid nodules, which were subjected to fine-needle aspiration biopsy. Secondary outcome measures: dose of levothyroxine required to treat hypothyroidism, thyroid peroxidase antibodies (anti-TPO), and anti-thyroglobulin antibodies (anti-Tg). Results. In group L, a nodule was observed in three patients, who all had a Bethesda II classification. In group P, a nodule was also observed in three patients, with two classified as Bethesda II and one as Bethesda III. The levothyroxine dose required by group L was significantly lower than that required by group P (P = 0 002). The anti-TPO and anti-Tg levels did not differ between the groups. Conclusion. LLLT, by the methods described, has been shown to be safe for the treatment of hypothyroidism resulting from CAT. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - HC/InRad Artigos e Materiais de Revistas Científicas - LIM/25 Artigos e Materiais de Revistas Científicas - LIM/43 Artigos e Materiais de Revistas Científicas - LIM/44 Artigos e Materiais de Revistas Científicas - ODS/03 |
File | Description | Size | Format | |
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art_HOFLING_Safety_and_Efficacy_of_LowLevel_Laser_Therapy_in_2018.PDF | publishedVersion (English) | 1.81 MB | Adobe PDF | View/Open |
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