Departamento de Radiologia e Oncologia - FM/MDR
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Outcomes With Pembrolizumab Monotherapy in Patients With Programmed Death-Ligand 1-Positive NSCLC With Brain Metastases: Pooled Analysis of KEYNOTE-001, 010, 024, and 042
JTO CLINICAL AND RESEARCH REPORTS, v.2, n.8, article ID 100205, 11p, 2021
Introduction: We retrospectively evaluated outcomes in patients with programmed death-ligand 1 (PD-L1)-positive non-small-cell lung cancer (NSCLC) to determine whether baseline (i.e., at study enrollment) brain metastases were associated with the efficacy of pembrolizumab versus chemotherapy.Meth...
HEPATOSPLENIC SCHISTOSOMIASIS-ASSOCIATED CHRONIC PORTAL VEIN THROMBOSIS: RISK FACTOR FOR HEPATOCELLULAR CARCINOMA?
ABCD-ARQUIVOS BRASILEIROS DE CIRURGIA DIGESTIVA-BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY, v.36, article ID e1763, 4p, 2023
BACKGROUND: Hepatosplenic schistosomiasis is an endemic disease prevalent in tropical countries and is associated with a high incidence of portal vein thrombosis. Inflammatory changes caused by both parasitic infection and portal thrombosis can lead to the development of chronic liver disease wit...
Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression
SCIENTIFIC REPORTS, v.13, n.1, article ID 21970, 15p, 2023
Exercise training reduces the incidence of several cancers, but the mechanisms underlying these effects are not fully understood. Exercise training can affect the spleen function, which controls the hematopoiesis and immune response. Analyzing different cancer models, we identified that 4T1, LLC,...
Oral squamous cell carcinoma cancer stem cells have different drug sensitive to pharmacological NFκB and histone deacetylation inhibition
AMERICAN JOURNAL OF CANCER RESEARCH, v.13, n.12, p.6038-6050, 2023
Despite many progresses in the development of new systemic therapies for oral squamous cell carcinoma (OSCC), the five-year survival rate of OSCC is low. The traditional chemotherapies approach (cisplatin - CDDP) shows some limitations like drug toxicity, limited efficacy, and drug resistance. Pr...
Betapapillomavirus natural history and co-detection with alphapapillomavirus in cervical samples of adult women
JOURNAL OF MEDICAL VIROLOGY, v.95, n.12, article ID e29288, 11p, 2023
Human papillomaviruses (HPV) of the genus Betapapillomavirus can infect both cutaneous and mucosal sites, but research on their natural history at mucosal sites remains scarce. We examined the risk factors and co-detection patterns of HPVs of the Betapapillomavirus and Alphapapillomavirus genera ...
28-day prognostic value of coronary artery calcification burden in critically ill patients with COVID-19
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, v.17, n.5, p.361-364, 2023
Human Papillomavirus 16 Lineage A Variants Associated With Persistent Genital Infections in Men: The HPV Infection in Men (HIM) Study
JOURNAL OF INFECTIOUS DISEASES, v.228, n.12, p.1748-1757, 2023
We show for the first time the influence of human papillomavirus (HPV) 16 nucleotide variability on the risk of persistent infection in the male genitalia. Our data suggest differences in the natural history of HPV-16 variants between men and women. Background Human papillomavirus (HPV) 16 non-A ...
Validation of automated image co-registration integrated into in-house software for voxel-based internal dosimetry on single-photon emission computed tomography images
RADIOLOGIA BRASILEIRA, v.56, n.3, p.137-144, 2023
Abstract Objective: To develop an automated co-registration system and test its performance, with and without a fiducial marker, on single-photon emission computed tomography (SPECT) images. Materials and Methods: Three SPECT/CT scans were acquired for each rotation of a Jaszczak phantom (to 0°, ...
Cortical thickness is related to working memory performance after non-invasive brain stimulation
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, v.56, article ID e12945, 8p, 2023
Non-invasive brain stimulation (NIBS) probing the dorsolateral prefrontal cortex (DLPFC) has been shown to have little effect on working memory. The variability of NIBS responses might be explained by inter-subject brain anatomical variability. We investigated whether baseline cortical brain thic...
Perilesional and contralesional brain activations related to associative encoding of unfamiliar face-names pairs in adults with left chronic stroke with or without ischemic infarct on left inferior frontal gyrus
CORTEX, v.168, p.27-48, 2023
The study of an Ischemic stroke infarction allows verifying how the lesion produces alterations in the neuronal networks resulting in cognitive deficits. It also allows the verification of adaptive and maladaptive cerebral reorganization related to the injury. In our previous fMRI study, we found...