Coleções desta comunidade

Novos documentos depositados

1. Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk

   HUMAN GENOMICS, v.18, n.1, article ID 12, 12p, 2024

   Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely tha...

2. Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson's Disease

   BRAIN SCIENCES, v.14, n.2, article ID 178, 18p, 2024

   Individuals with Parkinson's disease (PD) and freezing of gait (FOG) have a loss of presynaptic inhibition (PSI) during anticipatory postural adjustments (APAs) for step initiation. The mesencephalic locomotor region (MLR) has connections to the reticulospinal tract that mediates inhibitory inter...

3. Maxillary sinus volumetric changes in jet aircraft pilots: A multislice computed tomography pilot study

   IMAGING SCIENCE IN DENTISTRY, v.53, n.1, p.53-60, 2023

   Purpose: This study evaluated maxillary sinus volume changes in military jet aircraft pilot candidates before and after the training program, in comparison with a control group, considering the effects of pressurization, altitude, and total flight hours, through multislice computed tomography.Mat...

4. A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma

   CARCINOGENESIS, v.44, n.8-9, p.642-649, 2023

   Coding sequence variants comprise a small fraction of the germline genetic variability of the human genome. However, they often cause deleterious change in protein function and are therefore associated with pathogenic phenotypes. To identify novel pancreatic ductal adenocarcinoma (PDAC) risk loci...

5. Patentometric analysis as a subsid to the management of technological innovation: a case study in radiopharmaceuticals for cancer

   ENCONTROS BIBLI-REVISTA ELETRONICA DE BIBLIOTECONOMIA E CIENCIA DA INFORMACAO, v.28, article ID e93547, 21p, 2023

   Objective: Prospect the evolution of patent applications onIdentify, extract, process data, organize and make available technological information in the form of graphical interfaces described in oncology patents containing the radioisotopes gallium-68 (Ga-68), copper-64 (Cu-64) and zirconium-89 (...

6. Assessment of bioactive peptides derived from laminin-111 as prospective breast cancer-targeting agents

   AMINO ACIDS, v.56, n.1, article ID 1, 13p, 2024

   Breast cancer remains a pressing public health issue primarily affecting women. Recent research has spotlighted bioactive peptides derived from laminin-111, implicated in breast tumor development. Remarkably, the sequences IKVAV, YIGSR, and KAFDITYVRLKF from the alpha 1, beta 1, and gamma 1 chain...

7. Evaluation of Non-Invasive Methods for (R)-[<SUP>11</SUP>C]PK11195 PET Image Quantification in Multiple Sclerosis

   JOURNAL OF IMAGING, v.10, n.2, article ID 39, 14p, 2024

   This study aims to evaluate non-invasive PET quantification methods for (R)-[C-11]PK11195 uptake measurement in multiple sclerosis (MS) patients and healthy controls (HC) in comparison with arterial input function (AIF) using dynamic (R)-[C-11]PK11195 PET and magnetic resonance images. The total ...

8. Long-term outcomes of neoadjuvant immunotherapy plus chemotherapy in patients with early-stage triple-negative breast cancer: an extracted individual patient data and trial-level meta-analysis

   BRITISH JOURNAL OF CANCER, v.130, n.2, p.242-250, 2024

   Background: Neoadjuvant immunotherapy (nIO) has emerged as a treatment option for stage II-III triple-negative breast cancer (TNBC). While randomised clinical trials (RCTs) demonstrated pathological complete response rate benefit to nIO added to chemotherapy, additional data on long-term outcomes...

9. Impact of baseline and interim quantitative PET parameters on outcomes of classical Hodgkin Lymphoma

   ANNALS OF HEMATOLOGY, v.103, n.1, p.175-183, 2024

   Currently, analysis of interim PET (iPET) according to the Deauville score (DS) is the most important predictive factor in Hodgkin lymphoma (HL); however, there is room for improvement in its prognostic power. This study aimed to evaluate the prognostic value of quantitative PET analysis (maximum...

10. Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic

    FRONTIERS IN PUBLIC HEALTH, v.12, article ID 1369129, 15p, 2024

    Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management r...