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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | SHOKUR, Solaiman | |
dc.contributor.author | DONATI, Ana R. C. | |
dc.contributor.author | CAMPOS, Debora S. F. | |
dc.contributor.author | GITTI, Claudia | |
dc.contributor.author | BAO, Guillaume | |
dc.contributor.author | FISCHER, Dora | |
dc.contributor.author | ALMEIDA, Sabrina | |
dc.contributor.author | BRAGA, Vania A. S. | |
dc.contributor.author | AUGUSTO, Patricia | |
dc.contributor.author | PETTY, Chris | |
dc.contributor.author | ALHO, Eduardo J. L. | |
dc.contributor.author | LEBEDEV, Mikhail | |
dc.contributor.author | SONG, Allen W. | |
dc.contributor.author | NICOLELIS, Miguel A. L. | |
dc.date.accessioned | 2019-01-17T13:37:01Z | - |
dc.date.available | 2019-01-17T13:37:01Z | - |
dc.date.issued | 2018 | |
dc.identifier.citation | PLOS ONE, v.13, n.11, article ID e0206464, 33p, 2018 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/30075 | - |
dc.description.abstract | Spinal cord injury (SCI) induces severe deficiencies in sensory-motor and autonomic functions and has a significant negative impact on patients' quality of life. There is currently no systematic rehabilitation technique assuring recovery of the neurological impairments caused by a complete SCI. Here, we report significant clinical improvement in a group of seven chronic SCI patients (six AIS A, one AIS B) following a 28-month, multi-step protocol that combined training with non-invasive brain-machine interfaces, visuo-tactile feedback and assisted locomotion. All patients recovered significant levels of nociceptive sensation below their original SCI (up to 16 dermatomes, average 11 dermatomes), voluntary motor functions (lower-limbs muscle contractions plus multi-joint movements) and partial sensory function for several modalities (proprioception, tactile, pressure, vibration). Patients also recovered partial intestinal, urinary and sexual functions. By the end of the protocol, all patients had their AIS classification upgraded (six from AIS A to C, one from B to C). These improvements translated into significant changes in the patients' quality of life as measured by standardized psychological instruments. Reexamination of one patient that discontinued the protocol after 12 months of training showed that the 16-month break resulted in neurological stagnation and no reclassification. We suggest that our neurorehabilitation protocol, based uniquely on non-invasive technology (therefore necessitating no surgical operation), can become a promising therapy for patients diagnosed with severe paraplegia (AIS A, B), even at the chronic phase of their lesion. | eng |
dc.description.sponsorship | Brazilian Financing Agency for Studies and Projects [FINEP 01.12.0514.00] | |
dc.description.sponsorship | Brazilian Ministry of Science, Technology, Innovation and Communication (MCTIC) | |
dc.description.sponsorship | Itau Unibanco S.A. | |
dc.description.sponsorship | National Institute of Science and Technology Program (INCT) of the National Council of Scientific and Technological Development (CNPq/MCTIC) [INCEMAQ 610009/2009-5] | |
dc.language.iso | eng | |
dc.publisher | PUBLIC LIBRARY SCIENCE | eng |
dc.relation.ispartof | Plos One | |
dc.rights | openAccess | eng |
dc.subject.other | spinal-cord-injury | eng |
dc.subject.other | motor cortex stimulation | eng |
dc.subject.other | sacral nerve-stimulation | eng |
dc.subject.other | open-source software | eng |
dc.subject.other | quality-of-life | eng |
dc.subject.other | computer interfaces | eng |
dc.subject.other | neurogenic bladder | eng |
dc.subject.other | neuropathic pain | eng |
dc.subject.other | recovery | eng |
dc.subject.other | rehabilitation | eng |
dc.title | Training with brain-machine interfaces, visuotactile feedback and assisted locomotion improves sensorimotor, visceral, and psychological signs in chronic paraplegic patients | eng |
dc.type | article | eng |
dc.rights.holder | Copyright PUBLIC LIBRARY SCIENCE | eng |
dc.identifier.doi | 10.1371/journal.pone.0206464 | |
dc.identifier.pmid | 30496189 | |
dc.subject.wos | Multidisciplinary Sciences | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | SHOKUR, Solaiman:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil | |
hcfmusp.author.external | DONATI, Ana R. C.:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil; AACD, Sao Paulo, Brazil | |
hcfmusp.author.external | CAMPOS, Debora S. F.:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil | |
hcfmusp.author.external | GITTI, Claudia:AACD, Sao Paulo, Brazil | |
hcfmusp.author.external | BAO, Guillaume:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil | |
hcfmusp.author.external | FISCHER, Dora:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil; AACD, Sao Paulo, Brazil | |
hcfmusp.author.external | ALMEIDA, Sabrina:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil; AACD, Sao Paulo, Brazil | |
hcfmusp.author.external | BRAGA, Vania A. S.:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil | |
hcfmusp.author.external | AUGUSTO, Patricia:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil | |
hcfmusp.author.external | PETTY, Chris:Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Durham, NC USA | |
hcfmusp.author.external | LEBEDEV, Mikhail:Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA; Duke Univ, Duke Ctr Neuroengn, Durham, NC 27708 USA | |
hcfmusp.author.external | SONG, Allen W.:Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Durham, NC USA | |
hcfmusp.author.external | NICOLELIS, Miguel A. L.:AASDAP, Neurorehabil Lab, Sao Paulo, Brazil; Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA; Duke Univ, Duke Ctr Neuroengn, Durham, NC 27708 USA; Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA; Duke Univ, Dept Neurol, Durham, NC 27708 USA; Duke Univ, Dept Neurosurg, Durham, NC 27708 USA; Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA; Edmond & Lily Safra Int Inst Neurosci, Macaiba, Brazil | |
hcfmusp.description.articlenumber | e0206464 | |
hcfmusp.description.issue | 11 | |
hcfmusp.description.volume | 13 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000451763800015 | |
hcfmusp.origem.id | 2-s2.0-85057446770 | |
hcfmusp.publisher.city | SAN FRANCISCO | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
hcfmusp.citation.scopus | 29 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros |
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