Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial
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Citações na Scopus
17
Tipo de produção
article
Data de publicação
2020
Título da Revista
ISSN da Revista
Título do Volume
Editora
ASSOC BRASILEIRA PSIQUIATRIA
Autores
CARRACEDO, Angel
AMIGO, Olalla M.
PELLICER, Ana L.
CARVALHO, Andre F.
Citação
BRAZILIAN JOURNAL OF PSYCHIATRY, v.42, n.2, p.128-135, 2020
Resumo
Objective: We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. Methods: Data from the Escitalopram vs. Electrical Current Therapy for Treating Depression Clinical Study (ELECT-TDCS) were used. Participants were antidepressant-free at baseline and presented with an acute, moderate-to-severe unipolar depressive episode. They were randomized to receive escitalopram/tDCS-sham (n=75), tDCS/placebo-pill (n=75), or placebo-pill/sham-tDCS (n=45). General linear models assessed the interaction between treatment group and allele-wise carriers. Additional analyses were performed for each group and each genotype separately. Results: Pairwise group comparisons (tDCS vs. placebo, tDCS vs. escitalopram, and escitalopram vs. placebo) did not identify alleles associated with depression improvement. In addition, exploratory analyses also did not identify any SNP unequivocally associated with improvement of depression in any treatment group. Conclusion: Larger, combined datasets are necessary to identify candidate genes for tDCS response.
Palavras-chave
Major depressive disorder, non-invasive brain stimulation, single-nucleotide polymorphism, selective serotonin reuptake inhibitors, randomized clinical trial
Referências
- Amorim Patricia, 2000, Revista Brasileira de Psiquiatria, V22, P106
- Antal A, 2017, CLIN NEUROPHYSIOL, V128, P1774, DOI 10.1016/j.clinph.2017.06.001
- Aparicio LVM, 2016, BRAIN STIMUL, V9, P671, DOI 10.1016/j.brs.2016.05.004
- Baeken Chris, 2011, Dialogues Clin Neurosci, V13, P139
- Bikson M, 2018, BRAIN STIMUL, V11, P465, DOI 10.1016/j.brs.2017.12.008
- Bocchio-Chiavetto L, 2008, NEUROSCI LETT, V437, P130, DOI 10.1016/j.neulet.2008.04.005
- Borrione L, 2018, J ECT, V34, P153, DOI 10.1097/YCT.0000000000000512
- Brunoni AR, 2017, NEW ENGL J MED, V376, P2523, DOI 10.1056/NEJMoa1612999
- Brunoni AR, 2013, EUR NEUROPSYCHOPHARM, V23, P1530, DOI 10.1016/j.euroneuro.2013.03.009
- Brunoni AR, 2019, BRAZ J PSYCHIAT, V41, P70, DOI 10.1590/1516-4446-2017-0018
- Brunoni AR, 2018, PROG NEURO-PSYCHOPH, V86, P211, DOI 10.1016/j.pnpbp.2018.06.003
- Brunoni AR, 2016, BRIT J PSYCHIAT, V208, P522, DOI 10.1192/bjp.bp.115.164715
- Brunoni AR, 2015, WORLD J BIOL PSYCHIA, V16, P114, DOI 10.3109/15622975.2014.958101
- Brunoni AR, 2014, EUR NEUROPSYCHOPHARM, V24, P1144, DOI 10.1016/j.euroneuro.2014.03.006
- Brunoni AR, 2015, SAO PAULO MED J, V133, P252, DOI 10.1590/1516-3180.2014.00351712
- Brunoni AR, 2012, BRAIN STIMUL, V5, P175, DOI 10.1016/j.brs.2011.03.002
- Brunoni AR, 2011, INT J METH PSYCH RES, V20, pE19, DOI 10.1002/mpr.338
- Chen ZY, 2006, SCIENCE, V314, P140, DOI 10.1126/science.1129663
- Collier DA, 1996, MOL PSYCHIATR, V1, P453
- Crisafulli C, 2011, FRONT PHARMACOL, V2, DOI 10.3389/fphar.2011.00006
- de la Fuente-Fernandez R, 2004, BIOL PSYCHIAT, V56, P67, DOI 10.1016/j.biopsych.2003.11.019
- Domschke K, 2010, INT J NEUROPSYCHOPH, V13, P93, DOI 10.1017/S1461145709000030
- Du LS, 2000, AM J MED GENET, V96, P56, DOI 10.1002/(SICI)1096-8628(20000207)96:1<56::AID-AJMG12>3.0.CO;2-L
- Egan MF, 2003, CELL, V112, P257, DOI 10.1016/S0092-8674(03)00035-7
- Fernandes BS, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0849-x
- Fischer S, 2019, NEUROSCI BIOBEHAV R, V96, P182, DOI 10.1016/j.neubiorev.2018.11.009
- Gabriel Stacey, 2009, Curr Protoc Hum Genet, VChapter 2, DOI 10.1002/0471142905.hg0212s60
- Gaynes BN, 2008, CLEV CLIN J MED, V75, P57, DOI 10.3949/ccjm.75.1.57
- Hing B, 2018, AM J MED GENET B, V177, P143, DOI 10.1002/ajmg.b.32616
- Jongkees BJ, 2019, EUR J NEUROSCI, V49, P263, DOI 10.1111/ejn.14261
- Kaiser RH, 2015, JAMA PSYCHIAT, V72, P603, DOI 10.1001/jamapsychiatry.2015.0071
- Kato M, 2010, MOL PSYCHIATR, V15, P473, DOI 10.1038/mp.2008.116
- Kishi T, 2013, EUR ARCH PSY CLIN N, V263, P105, DOI 10.1007/s00406-012-0337-4
- Lauretto MS, 2009, GENET MOL BIOL, V32, P619, DOI 10.1590/S1415-47572009000300028
- Lin JY, 2014, J AFFECT DISORDERS, V168, P430, DOI 10.1016/j.jad.2014.06.012
- Loo CK, 2018, BRAIN STIMUL, V11, P125, DOI 10.1016/j.brs.2017.10.011
- LOTTA T, 1995, BIOCHEMISTRY-US, V34, P4202, DOI 10.1021/bi00013a008
- Malhotra AK, 2002, AM J PSYCHIAT, V159, P652, DOI 10.1176/appi.ajp.159.4.652
- Martin DM, 2018, BRAIN STIMUL, V11, P1282, DOI 10.1016/j.brs.2018.08.011
- Martin DM, 2018, NEUROSCI BIOBEHAV R, V90, P137, DOI 10.1016/j.neubiorev.2018.04.008
- Moffa AH, 2018, PSYCHIAT CLIN N AM, V41, P447, DOI 10.1016/j.psc.2018.05.002
- Monte-Silva K, 2010, J PHYSIOL-LONDON, V588, P3415, DOI 10.1113/jphysiol.2010.190181
- Mutz J, 2018, NEUROSCI BIOBEHAV R, V92, P291, DOI 10.1016/j.neubiorev.2018.05.015
- Palm U, 2018, NEUROMODULATION, V21, P323, DOI 10.1111/ner.12686
- Palm U, 2013, J AFFECT DISORDERS, V150, P659, DOI 10.1016/j.jad.2013.03.015
- Parra FC, 2003, P NATL ACAD SCI USA, V100, P177, DOI 10.1073/pnas.0126614100
- Pattwell SS, 2012, J NEUROSCI, V32, P2410, DOI 10.1523/JNEUROSCI.5205-11.2012
- Plewnia C, 2013, CORTEX, V49, P1801, DOI 10.1016/j.cortex.2012.11.002
- Seibt O, 2015, BRAIN STIMUL, V8, P590, DOI 10.1016/j.brs.2015.01.401
- Serretti A, 2007, MOL PSYCHIATR, V12, P247, DOI 10.1038/sj.mp.4001926
- Sherry ST, 2001, NUCLEIC ACIDS RES, V29, P308, DOI 10.1093/nar/29.1.308
- Silverstein WK, 2015, DEPRESS ANXIETY, V32, P871, DOI 10.1002/da.22424
- Stephens JA, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-14030-7
- Van Oekelen D, 2003, LIFE SCI, V72, P2429, DOI 10.1016/S0024-3205(03)00141-3
- Woods AJ, 2016, CLIN NEUROPHYSIOL, V127, P1031, DOI 10.1016/j.clinph.2015.11.012
- Zhao XF, 2015, PSYCHIAT GENET, V25, P1, DOI 10.1097/YPG.0000000000000070
- Zou YF, 2010, EUR NEUROPSYCHOPHARM, V20, P535, DOI 10.1016/j.euroneuro.2009.12.005
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - LIM/27
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - LIM/27