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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | LEOCADIO, Paola | |
dc.contributor.author | MENTA, Penelope | |
dc.contributor.author | DIAS, Melissa | |
dc.contributor.author | FRAGA, Julia | |
dc.contributor.author | GOULART, Alessandra | |
dc.contributor.author | SANTOS, Itamar | |
dc.contributor.author | LOTUFO, Paulo | |
dc.contributor.author | BENSENOR, Isabela | |
dc.contributor.author | ALVAREZ-LEITE, Jacqueline | |
dc.date.accessioned | 2020-06-01T14:46:39Z | - |
dc.date.available | 2020-06-01T14:46:39Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.114, n.3, p.507-514, 2020 | |
dc.identifier.issn | 0066-782X | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35832 | - |
dc.description.abstract | Background: Several markers have been evaluated for a potential impact on clinical decisions or mortality prediction in acute coronary syndrome (ACS), including Netrin-1 and IL-1 beta that have been associated with cardiovascular disease. Objective: Our study examined the prognostic value of Netrin-1 and IL-1 beta in patients with ACS (2-year follow-up). Methods: We evaluate Netrin-1, IL-1 beta and other risk factors in the serum sample of 803 patients. Kaplan-Meier curves and Cox regression were used for the analysis of all-cause mortality, cardiovascular mortality, and a combined outcome of fatal myocardial infarction (MI) or new non-fatal MI, considering p-value < 0.05. Results: There were 115 deaths from all causes, 78 deaths due to cardiovascular causes and 67 events in combined outcomes. Netrin-1 levels above the median (>44.8 pg/mL) were associated with a worse prognosis (all-cause mortality and cardiovascular mortality) in elderly females, even after model adjustment (HR: 2.08, p = 0.038 and HR: 2.68, p = 0.036). IL-1 beta levels above the median (>13.4 pg/mL) in elderly females were associated with increased risk of all outcomes after adjustment (all-cause mortality - HR: 2.03, p = 0.031; cardiovascular mortality - HR: 3.01, p = 0.013; fatal MI or new non-fatal MI - HR: 3.05, p = 0.029). For males, no associations were observed between Netrin-1 or IL-1 beta and outcomes. Conclusion: High serum levels of Netrin-1 and IL-1 beta showed significant association with worse prognosis in elderly females. They may be useful as prognostic indicators in ACS. | eng |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) | |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCAPES | |
dc.language.iso | eng | |
dc.publisher | ARQUIVOS BRASILEIROS CARDIOLOGIA | eng |
dc.relation.ispartof | Arquivos Brasileiros de Cardiologia | |
dc.rights | openAccess | eng |
dc.subject | Acute Coronary Syndrome/physiopathology | eng |
dc.subject | Netrin-1 | eng |
dc.subject | Interleukin-1 beta | eng |
dc.subject | Atrial Remodeling | eng |
dc.subject | Hypertension | eng |
dc.subject | Diabetes Mellitus | eng |
dc.subject | Dyslipidemias | eng |
dc.subject | Stroke | eng |
dc.subject | Aged | eng |
dc.subject | Women | eng |
dc.subject.other | myocardial-infarction | eng |
dc.subject.other | unstable angina | eng |
dc.subject.other | heart-disease | eng |
dc.subject.other | expression | eng |
dc.subject.other | inflammation | eng |
dc.subject.other | injury | eng |
dc.subject.other | mice | eng |
dc.title | High Serum Netrin-1 and IL-1 beta in Elderly Females with ACS: Worse Prognosis in 2-years Follow-up | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ARQUIVOS BRASILEIROS CARDIOLOGIA | eng |
dc.identifier.doi | 10.36660/abc.20190035 | |
dc.identifier.pmid | 32267322 | |
dc.subject.wos | Cardiac & Cardiovascular Systems | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | LEOCADIO, Paola:Univ Fed Minas Gerais, Dept Bioquim & Imunol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | MENTA, Penelope:Univ Fed Minas Gerais, Dept Bioquim & Imunol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | DIAS, Melissa:Univ Fed Minas Gerais, Dept Bioquim & Imunol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | FRAGA, Julia:Univ Fed Minas Gerais, Dept Bioquim & Imunol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | ALVAREZ-LEITE, Jacqueline:Univ Fed Minas Gerais, Dept Bioquim & Imunol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil | |
hcfmusp.description.beginpage | 507 | |
hcfmusp.description.endpage | 514 | |
hcfmusp.description.issue | 3 | |
hcfmusp.description.volume | 114 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000523652900015 | |
hcfmusp.origem.id | 2-s2.0-85082811961 | |
hcfmusp.origem.id | SCIELO:S0066-782X2020000300507 | |
hcfmusp.publisher.city | RIO DE JANEIRO | eng |
hcfmusp.publisher.country | BRAZIL | eng |
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dc.description.index | MEDLINE | eng |
hcfmusp.citation.scopus | 7 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HU Artigos e Materiais de Revistas Científicas - LIM/20 Artigos e Materiais de Revistas Científicas - LIM/51 Artigos e Materiais de Revistas Científicas - ODS/03 |
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