Age-related changes in the articular cartilage of the mandible of rats

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Citações na Scopus
0
Tipo de produção
article
Data de publicação
2020
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER GMBH
Autores
CALDERON, M. F.
SOUZA, R. R. de
Citação
ACTA HISTOCHEMICA, v.122, n.2, article ID UNSP 151501, 4p, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
This study investigated the effects of aging on the articular cartilage of the mandible. Wistar rats were divided in two groups (n = 10/per group): 3-months-old group (young group); and 13-months-old group (aged group). After euthanasia, the head of the mandible was collected and stained with hematoxylin and eosin (HE) to evaluate the thickness of the articular layer and cartilage. Sections stained with Picrosirius red and Safranin O were used to evaluate the collagen and proteoglycans deposition, respectively. First, aging has decreased the articular layer thickness. Second, the results suggest a decrease of chondrocytes followed by an increase of the matrix to maintain the mandible homeostasis. Finally, both collagen and proteoglycans increased with aging. Aging displayed important effects to the mandible of aged rats.
Palavras-chave
Aging, Mandible, Morphometry, Rat
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