• BRAZILIAN SOCIETY OF HEPATOLOGY UPDATED RECOMMENDATIONS FOR DIAGNOSIS AND TREATMENT OF HEPATOCELLULAR CARCINOMA 

  CHAGAS, Aline Lopes; MATTOS, Angelo Alves de; CARRILHO, Flair José; BITTENCOURT, Paulo Lisboa; VEZOZZO, Denise Cerqueira Paranaguá; HORVAT, Natally; ROCHA, Manoel de Souza; ALVES, Venâncio Avancini Ferreira; CORAL, Gabriela Perdomo; ALVARES-DA-SILVA, Mario Reis; BARROS, Fabio Marinho do Rego; MENEZES, Marcos Roberto; MONSIGNORE, Lucas Moretti; COELHO, Fabricio Ferreira; SILVA, Renato Ferreira da; SILVA, Rita de Cássia Martins Alves; BOIN, Ilka de Fatima Santana Ferreira; D`ALBUQUERQUE, Luiz Augusto Carneiro; GARCIA, José Huygens Parente; FELGA, Guilherme Eduardo Gonçalves; MOREIRA, Airton Mota; BRAGHIROLI, Maria Ignez Freitas Melro; HOFF, Paulo Marcelo Gehm; MELLO, Vivianne Barretto de; DOTTORI, Mariana Fonseca; BRANCO, Tiago Pugliese; SCHIAVON, Leonardo de Lucca; COSTA, Thaisa de Fátima Almeida (Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE., 2020)

  ABSTRACT Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2015 its first recommendations about the management of HCC. ...
• Response to anti-PD1 immunotherapy in patients with metastatic cutaneous sarcoma: case reports and literature review 

  VIEIRA, Aline Cristini; MEGID, Thais Baccili Cury; MELO, Raissa; MUNIZ, David; SALGUES, Alessandra Corte Real; BARBOSA, Felipe Galiza; MUNHOZ, Rodrigo Ramella; FEHER, Olavo (OXFORD UNIV PRESS, OXFORD, ENGLAND, 2020)

  Dermal sarcomas represent a group or rare malignancies of mesenchymal origin. Although surgical excision with wide margins can be curative, in the advanced/metastatic setting, treatment options are limited and the benefit ...
• Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in Sao Paulo, Brazil 

  KOWALSKI, Luiz Paulo; OLIVEIRA, Max Moura de; LOPEZ, Rossana Veronica Mendoza; SILVA, Diego Rodrigues Mendonca e; IKEDA, Mauro Kazuo; CURADO, Maria Paula (HOSPITAL CLINICAS, UNIV SAO PAULO, SAO PAULO, BRAZIL, 2020)

  OBJECTIVE: We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends. METHODS: The ...
• Human papillomavirus type 18 E5 oncoprotein cooperates with E6 and E7 in promoting cell viability and invasion and in modulating the cellular redox state 

  HOCHMANN, Jimena; PARIETTI, Felipe; MARTINEZ, Jennyfer; LOPEZ, Ana C.; CARRENO, Mara; QUIJANO, Celia; BOCCARDO, Enrique; SICHERO, Laura; MOLLER, Matias N.; MIRAZO, Santiago; ARBIZA, Juan (FUNDACO OSWALDO CRUZ, RIO DE JANEIRO, RJ, BRAZIL, 2020)

  BACKGROUND High-risk human papillomaviruses (HR-HPVs) are the etiological agents of cervical cancer. Among them, types 16 and 18 are the most prevalent worldwide. The HPV genome encodes three oncoproteins (E5, E6, and E7) ...
• Bicistronic transfer of CDKN2A and p53 culminates in collaborative killing of human lung cancer cells in vitro and in vivo 

  XANDE, Juliana G.; DIAS, Ana P.; TAMURA, Rodrigo E.; CRUZ, Mario C.; BRITO, Barbara; FERREIRA, Robledo A.; STRAUSS, Bryan E.; COSTANZI-STRAUSS, Eugenia (NATURE PUBLISHING GROUP, LONDON, ENGLAND, 2020)

  Cancer therapies that target a single protein or pathway may be limited by their specificity, thus missing key players that control cellular proliferation and contributing to the failure of the treatment. We propose that ...
• Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth 

  TAMURA, Rodrigo Esaki; LANA, Marlous G.; COSTANZI-STRAUSS, Eugenia; STRAUSS, Bryan E. (NATURE PUBLISHING GROUP, LONDON, ENGLAND, 2020)

  For patients with metastatic prostate cancer, the 5-year survival rate of 31% points to a need for novel therapies and improvement of existing modalities. We propose that p53 gene therapy and chemotherapy, when combined, ...
• Recommendations for Advancing the Diagnosis and Management of Hereditary Breast and Ovarian Cancer in Brazil 

  ACHATZ, Maria Isabel; CALEFFI, Maira; GUINDALINI, Rodrigo; MARQUES, Renato Moretti; NOGUEIRA-RODRIGUES, Angelica; ASHTON-PROLLA, Patricia (AMER SOC CLINICAL ONCOLOGY, ALEXANDRIA, USA, 2020)

  PURPOSEThe objective of this review was to address the barriers limiting access to genetic cancer risk assessment and genetic testing for individuals with suspected hereditary breast and ovarian cancer (HBOC) through a ...
• Gastric cancer molecular classification and adjuvant therapy: Is there a different benefit according to the subtype? 

  RAMOS, Marcus F. K. P.; PEREIRA, Marina A.; AMORIM, Larissa C.; MELLO, Evandro S. de; FARAJ, Sheila F.; JR, Ulysses Ribeiro; HOFF, Paulo M. G.; CECCONELLO, Ivan; CASTRIA, Tiago B. de (WILEY, HOBOKEN, USA, 2020)

  Background Gastric cancer (GC) has been defined in distinct molecular subtypes with different therapeutic implications. However, its clinical significance and prognosis regarding standard chemotherapy (CMT) remains unclear. ...
• The role of private education in the selection of primary care careers in low and middle-income countries. Findings from a representative survey of medical residents in Brazil 

  RUSSO, Giuliano; CASSENOTE, Alex J. Flores; GUILLOUX, Aline G. Alves; SCHEFFER, Mario Cesar (BMC, LONDON, ENGLAND, 2020)

  Background Primary health care (PHC) doctors' numbers are dwindling in high- as well as low-income countries, which is feared to hamper the achievement of Universal Health Coverage goals. As a large proportion of doctors ...
• How many and which physicians? A comparative study of the evolution of the supply of physicians and specialist training in Brazil and Spain 

  SCHEFFER, Mario Cesar; PASTOR-VALERO, Maria; CASSENOTE, Alex Jones Flores; ROSIQUE, Antonio F. Compan (BMC, LONDON, ENGLAND, 2020)

  Background In the face of the medical workforce shortage, several countries have promoted the opening of medical schools and the expansion of undergraduate and specialization education in medicine. Few studies have compared ...
• Prognostic Value of Tumor Regression Grade Based on Ryan Score in Squamous Cell Carcinoma and Adenocarcinoma of Esophagus 

  TAKEDA, Flavio Roberto; TUSTUMI, Francisco; OBREGON, Carlos de Almeida; YOGOLARE, Gustavo Goncalves; NAVARRO, Yasmin Peres; SEGATELLI, Vanderlei; SALLUM, Rubens Antonio Aissar; RIBEIRO JUNIOR, Ulysses; CECCONELLO, Ivan (SPRINGER, NEW YORK, UNITED STATES, 2020)

  Purposes Tumor regression grade (TRG) of the primary tumor after neoadjuvant therapy is one of the most sensitive prognostic factors among patients with locally advanced esophageal cancer, although no TRG system is fully ...
• Schistosomiasis Misleading Gastric Cancer Treatment 

  RAMOS, Marcus Fernando Kodama Pertille; DUARTE, Vinicius Campos; PEREIRA, Marina Alessandra; CASTRIA, Tiago Biachi de; SCHMERLING, Claudia Kliemann; ZILBERSTEIN, Bruno; RIBEIRO-JUNIOR, Ulysses; CECCONELLO, Ivan (SPRINGER, NEW YORK, UNITED STATES, 2020)
• The value of cellular components of blood in the setting of trimodal therapy for esophageal cancer 

  TUSTUMI, Francisco; TAKEDA, Flavio Roberto; VIYUELA, Mateus Silva; CRUZ JUNIOR, Jurandir Batista da; BRANDAO, Antonio Adolfo Guerra Soares; SALLUM, Rubens Antonio Aissar; RIBEIRO JUNIOR, Ulysses; CECCONELLO, Ivan (WILEY, HOBOKEN, USA, 2020)

  Background Inflammation status plays an important role in the natural history of malignancy. Consequently, hematological markers of systemic inflammation may predict prognosis in neoplasms. This study evaluated the value ...
• Diaphragmatic Hernia Repair After Esophagectomy: Technical Report and Lessons After a Series of Cases 

  TAKEDA, Flavio R.; TUSTUMI, Francisco; FILHO, Marco A. S.; SILVA, Matheus O.; JUNIOR, Ulysses R.; SALLUM, Rubens A. A.; CECCONELLO, Ivan (MARY ANN LIEBERT, INC, NEW ROCHELLE, USA, 2020)

  Introduction: Diaphragmatic hernia (DH) repair after esophagectomy is infrequent and technically challenging. Such hernias are mostly asymptomatic and have an estimated incidence of around 2.5%. Controversy continues over ...
• Impact of neoadjuvant chemotherapy on surgical and pathological results of gastric cancer patients: A case-control study 

  CHARRUF, Amir Zeide; RAMOS, Marcus Fernando Kodama Pertille; PEREIRA, Marina Alessandra; DIAS, Andre Roncon; CASTRIA, Tiago Biachi de; ZILBERSTEIN, Bruno; CECCONELO, Ivan; RIBEIRO, Ulysses (WILEY, HOBOKEN, USA, 2020)

  Background and Objective Neoadjuvant chemotherapy (NACT) followed by radical surgery represents a treatment option for patients with advanced gastric cancer (GC). This case-control study aimed to evaluate the clinicopathological ...
• Stem cell factor receptor gene mutation: Achalasia, mastocytosis and gastrointestinal stromal tumors 

  TUSTUMI, Francisco; SZOR, Daniel Jose; SALLUM, Rubens Antonio Aissar; CECCONELLO, Ivan (ELSEVIER SCIENCE INC, NEW YORK, USA, 2020)
• Return to Intended Oncologic Treatment (RIOT) in Resected Gastric Cancer Patients 

  RAMOS, Marcus Fernando Kodama Pertille; CASTRIA, Tiago Biachi de; PEREIRA, Marina Alessandra; DIAS, Andre Roncon; ANTONACIO, Fernanda Fronzoni; ZILBERSTEIN, Bruno; HOFF, Paulo Marcelo Gehm; RIBEIRO JR., Ulysses; CECCONELLO, Ivan (SPRINGER, NEW YORK, UNITED STATES, 2020)

  Background Postoperative chemotherapy (CMT) or chemoradiotherapy (CRT) is commonly recommended for gastric cancer (GC) patients in order to improve survival. However, some factors that prevent patients from return to ...
• Lymph node regression after neoadjuvant chemotherapy: A predictor of survival in gastric cancer 

  PEREIRA, Marina Alessandra; RAMOS, Marcus Fernando Kodama Pertille; DIAS, Andre Roncon; CARDILI, Leonardo; RIBEIRO, Renan Ribeiro e; CHARRUF, Amir Zeide; CASTRIA, Tiago Biachi de; ZILBERSTEIN, Bruno; CECONELLO, Ivan; ALVES, Venancio Avancini Ferreira; RIBEIRO JR., Ulysses; MELLO, Evandro Sobroza de (WILEY, HOBOKEN, USA, 2020)

  Background and Objective Neoadjuvant chemotherapy (nCMT) has been increasingly used in advanced gastric cancer (GC). However, the prognostic impact of tumor response remains unclear. This study aimed to evaluate if tumor ...
• Multivisceral resection vs standard gastrectomy for gastric adenocarcinoma 

  DIAS, Andre R.; PEREIRA, Marina A.; OLIVEIRA, Rodrigo J.; RAMOS, Marcus F. K. P.; SZOR, Daniel J.; RIBEIRO, Ulysses; ZILBERSTEIN, Bruno; CECCONELLO, Ivan (WILEY, HOBOKEN, USA, 2020)

  Introduction Multivisceral resection (MVR) is potentially curative for selected gastric cancer patients, supposedly at the cost of increased complications. However, current data comparing MVR to standard gastrectomy (SG) ...
• How should health systems prepare for the evolving COVID-19 pandemic? Reflections from the perspective of a Tertiary Cancer Center 

  CHEN, Andre Tsin Chih; MONIZ, Camila Motta Venchiarutti; RIBEIRO-JUNIOR, Ulysses; DIZ, Maria del Pilar Estevez; SALVAJOLI, Joao Victor; VASCONCELOS, Karina Gondim Moutinho Da Conceicao; AULER-JUNIOR, Jose Otavio Costa; CECCONELLO, Ivan; ABDALA, Edson; HOFF, Paulo Marcelo Gehm (HOSPITAL CLINICAS, UNIV SAO PAULO, SAO PAULO, BRAZIL, 2020)

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