Analysis of Epigenetic Age Predictors in Pain-Related Conditions

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art_KWIATKOWSKA_Analysis_of_Epigenetic_Age_Predictors_in_PainRelated_Conditions_2020.PDF (751.63 KB)
Citações na Scopus
8
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
KWIATKOWSKA, Katarzyna Malgorzata
BACALINI, Maria Giulia
SALA, Claudia
TERLIZZI, Rossana
GIANNINI, Giulia
CEVOLI, Sabina
PIERANGELI, Giulia
CORTELLI, Pietro
Citação
FRONTIERS IN PUBLIC HEALTH, v.8, article ID 172, 14p, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Chronic pain prevalence is high worldwide and increases at older ages. Signs of premature aging have been associated with chronic pain, but few studies have investigated aging biomarkers in pain-related conditions. A set of DNA methylation (DNAm)-based estimates of age, called ""epigenetic clocks,"" has been proposed as biological measures of age-related adverse processes, morbidity, and mortality. The aim of this study is to assess if different pain-related phenotypes show alterations in DNAm age. In our analysis, we considered three cohorts for which whole-blood DNAm data were available: heat pain sensitivity (HPS), including 20 monozygotic twin pairs discordant for heat pain temperature threshold; fibromyalgia (FM), including 24 cases and 20 controls; and headache, including 22 chronic migraine and medication overuse headache patients (MOH), 18 episodic migraineurs (EM), and 13 healthy subjects. We used the Horvath's epigenetic age calculator to obtain DNAm-based estimates of epigenetic age, telomere length, levels of 7 proteins in plasma, number of smoked packs of cigarettes per year, and blood cell counts. We did not find differences in epigenetic age acceleration, calculated using five different epigenetic clocks, between subjects discordant for pain-related phenotypes. Twins with high HPS had increased CD8+ T cell counts (nominalp= 0.028). HPS thresholds were negatively associated with estimated levels of GDF15 (nominalp= 0.008). FM patients showed decreased naive CD4+ T cell counts compared with controls (nominalp= 0.015). The severity of FM manifestations expressed through various evaluation tests was associated with decreased levels of leptin, shorter length of telomeres, and reduced CD8+ T and natural killer cell counts (nominalp< 0.05), while the duration of painful symptoms was positively associated with telomere length (nominalp= 0.034). No differences in DNAm-based estimates were detected for MOH or EM compared with controls. In summary, our study suggests that HPS, FM, and MOH/EM do not show signs of epigenetic age acceleration in whole blood, while HPS and FM are associated with DNAm-based estimates of immunological parameters, plasma proteins, and telomere length. Future studies should extend these observations in larger cohorts.
Palavras-chave
epigenetic aging, aging biomarker, epigenetic clock, chronic pain, pain sensitivity, fibromyalgia, headache, DNA methylation
URI
https://observatorio.fm.usp.br/handle/OPI/37271
Referências
  1. Aryee MJ, 2014, BIOINFORMATICS, V30, P1363, DOI 10.1093/bioinformatics/btu049
  2. Bell JT, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms3978
  3. Breivik H, 2006, EUR J PAIN, V10, P287, DOI 10.1016/j.ejpain.2005.06.009
  4. Brekke M, 2002, SOC SCI MED, V54, P221, DOI 10.1016/S0277-9536(01)00018-1
  5. Campbell CM, 2012, PAIN MANAG, V2, P219, DOI 10.2217/PMT.12.7
  6. Cao S, 2019, J PAIN RES, V12, P3013, DOI 10.2147/JPR.S219084
  7. Cauda F, 2014, NEUROIMAGE-CLIN, V4, P676, DOI 10.1016/j.nicl.2014.04.007
  8. Che RL, 2012, GENET EPIDEMIOL, V36, P890, DOI 10.1002/gepi.21671
  9. Chong CD, 2014, CEPHALALGIA, V34, P1115, DOI 10.1177/0333102414531157
  10. Conte M, 2019, J GERONTOL A-BIOL, V74, P600, DOI 10.1093/gerona/gly153
  11. Cruz-Almeida Y, 2019, MOL PAIN, V15, DOI 10.1177/1744806919871819
  12. Cruz-Almeida Y, 2020, PAIN, V161, P461, DOI 10.1097/j.pain.0000000000001757
  13. Cruz-Almeida Y, 2019, PAIN, V160, P1119, DOI 10.1097/j.pain.0000000000001491
  14. da Silva LA, 2014, ORAL DIS, V20, pe103, DOI 10.1111/odi.12145
  15. de Andrade DC, 2017, PAIN, V158, P1473, DOI 10.1097/j.pain.0000000000000932
  16. Demissie S, 2011, GENET EPIDEMIOL, V35, P592, DOI 10.1002/gepi.20607
  17. Dominick CH, 2012, PAIN, V153, P293, DOI 10.1016/j.pain.2011.09.018
  18. Dong X, 2017, NEUROSCI LETT, V636, P127, DOI 10.1016/j.neulet.2016.10.054
  19. Edwards RR, 2003, PAIN, V101, P155, DOI 10.1016/S0304-3959(02)00324-X
  20. El Khoury LY, 2019, GENOME BIOL, V20, DOI 10.1186/s13059-019-1810-4
  21. El-Tumi H, 2018, OPEN PAIN J, V11, P41, DOI [10.2174/1876386301811010041, DOI 10.2174/1876386301811010041]
  22. Elliott AM, 2002, PAIN, V99, P299, DOI 10.1016/S0304-3959(02)00138-0
  23. Fayaz A, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010364
  24. Fiorito G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16391-5
  25. Fjell AM, 2010, REV NEUROSCIENCE, V21, P187, DOI 10.1515/revneuro.2010.21.3.187
  26. Fortin JP, 2017, BIOINFORMATICS, V33, P558, DOI 10.1093/bioinformatics/btw691
  27. Fransquet PD, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0656-7
  28. Free Mary Moore, 2002, Proc (Bayl Univ Med Cent), V15, P143
  29. Gan TJ, 2017, J PAIN RES, V10, P2287, DOI 10.2147/JPR.S144066
  30. Greenspan JD, 2007, PAIN, V132, pS26, DOI 10.1016/j.pain.2007.10.014
  31. Groven N, 2019, BRAIN BEHAV IMMUN, V81, P172, DOI 10.1016/j.bbi.2019.06.010
  32. Hannum G, 2013, MOL CELL, V49, P359, DOI 10.1016/j.molcel.2012.10.016
  33. Hassett Afton L, 2015, Curr Aging Sci, V8, P178
  34. Hassett AL, 2012, J PAIN, V13, P959, DOI 10.1016/j.jpain.2012.07.003
  35. Heft MW, 2010, J DENT RES, V89, P1102, DOI 10.1177/0022034510375287
  36. Helme RD, 2004, NEUROSCI LETT, V361, P144, DOI 10.1016/j.neulet.2003.12.014
  37. Hitt HC, 2007, J PAIN, V8, P430, DOI 10.1016/j.jpain.2006.12.003
  38. Horvath S, 2018, AGING-US, V10, P1758, DOI 10.18632/aging.101508
  39. Horvath S, 2018, NAT REV GENET, V19, P371, DOI 10.1038/s41576-018-0004-3
  40. Horvath S, 2016, GENOME BIOL, V17, DOI 10.1186/s13059-016-1030-0
  41. Horvath S, 2015, AGING-US, V7, P1130, DOI 10.18632/aging.100859
  42. Horvath S, 2015, J INFECT DIS, V212, P1563, DOI 10.1093/infdis/jiv277
  43. Horvath S, 2015, AGING CELL, V14, P491, DOI 10.1111/acel.12325
  44. Horvath S, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r115
  45. Houseman EA, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-86
  46. Jank R, 2017, PAIN RES TREAT, V2017, DOI 10.1155/2017/9081802
  47. Johnson MI, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55050182
  48. Jones CJ, 2015, J AGING PHYS ACTIV, V23, P103, DOI [10.1123/japa.2013-0159, 10.1123/JAPA.2013-0159]
  49. Jylhava J, 2017, EBIOMEDICINE, V21, P29, DOI 10.1016/j.ebiom.2017.03.046
  50. Kuchinad A, 2007, J NEUROSCI, V27, P4004, DOI 10.1523/JNEUROSCI.0098-07.2007
  51. Lasselin J, 2016, J BEHAV MED, V39, P916, DOI 10.1007/s10865-016-9769-z
  52. Laumet G, 2019, FRONT MOL NEUROSCI, V12, DOI 10.3389/fnmol.2019.00216
  53. Lautenbacher S, 2017, NEUROSCI BIOBEHAV R, V75, P104, DOI 10.1016/j.neubiorev.2017.01.039
  54. Lautenbacher S, 2012, PAIN MED, V13, pS44, DOI 10.1111/j.1526-4637.2012.01326.x
  55. Lehallier B, 2019, NAT MED, V25, P1843, DOI 10.1038/s41591-019-0673-2
  56. Levine ME, 2018, AGING-US, V10, P573, DOI 10.18632/aging.101414
  57. Levine ME, 2015, AGING-US, V7, P1198, DOI 10.18632/aging.100864
  58. Li X, 2013, MOL PAIN, V9, DOI 10.1186/1744-8069-9-65
  59. Lu AT, 2019, AGING-US, V11, P5895, DOI 10.18632/aging.102173
  60. Lu AT, 2019, AGING-US, V11, P303, DOI 10.18632/aging.101684
  61. Lue YJ, 2018, EUR J PAIN, V22, P1035, DOI 10.1002/ejp.1188
  62. Magerl W, 2010, PAIN, V151, P598, DOI 10.1016/j.pain.2010.07.026
  63. Magon S, 2019, CEPHALALGIA, V39, P665, DOI 10.1177/0333102418795163
  64. Maierhofer A, 2017, AGING-US, V9, P1143, DOI 10.18632/aging.101217
  65. Maksimovic Jovana, 2016, F1000Res, V5, P1281, DOI 10.12688/f1000research.8839.3
  66. Maleki N, 2019, NEUROPSYCHOLOGY, V33, P795, DOI 10.1037/neu0000558
  67. Fernandez-Martos CM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035594
  68. McHugh RC, 2008, PAIN PHYSICIAN, V11, P249
  69. Melvin A, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-02153-6
  70. MERSKEY H, 1994, CLASSIFICATION CHRON, P209
  71. Mills SEE, 2019, BRIT J ANAESTH, V123, pE273, DOI 10.1016/j.bja.2019.03.023
  72. Mior S, 2001, CLIN J PAIN, V17, pS77, DOI 10.1097/00002508-200112001-00016
  73. Moayyeri A, 2013, INT J EPIDEMIOL, V42, P76, DOI 10.1093/ije/dyr207
  74. Olama SM, 2013, INT J RHEUM DIS, V16, P583, DOI 10.1111/1756-185X.12155
  75. Petrini L, 2015, PERCEPTION, V44, P587, DOI 10.1068/p7847
  76. Prasad KN, 2017, MECH AGEING DEV, V164, P61, DOI 10.1016/j.mad.2017.04.004
  77. Quach A, 2017, AGING-US, V9, P419, DOI 10.18632/aging.101168
  78. Rainville J, 2011, SPINE J, V11, P895, DOI 10.1016/j.spinee.2011.08.006
  79. Ren H, 2010, HEADACHE, V50, P965, DOI 10.1111/j.1526-4610.2010.01693.x
  80. Robinson ME, 2011, J PAIN, V12, P436, DOI 10.1016/j.jpain.2010.10.003
  81. Rodriguez-Andreu J, 2009, BMC MUSCULOSKEL DIS, V10, DOI 10.1186/1471-2474-10-162
  82. Sa Katia Nunes, 2019, Pain Rep, V4, pe779, DOI 10.1097/PR9.0000000000000779
  83. Sibille Kimberly T, 2017, Pain Rep, V2, pe591, DOI 10.1097/PR9.0000000000000591
  84. Smallwood RF, 2013, J PAIN, V14, P663, DOI 10.1016/j.jpain.2013.03.001
  85. Soros P, 2020, PAIN, V161, P641, DOI 10.1097/j.pain.0000000000001756
  86. Sukenaga N, 2016, PAIN MED, V17, P1906, DOI 10.1093/pm/pnv088
  87. Teasell RW, 2001, CLIN J PAIN, V17, pS39, DOI 10.1097/00002508-200112001-00010
  88. Teodorezyk-Injeyan JA, 2019, CLIN J PAIN, V35, P818, DOI 10.1097/AJP.0000000000000745
  89. Terlizzi R, 2018, NEUROL SCI, V39, pS67, DOI 10.1007/s10072-018-3348-8
  90. Tsang A, 2008, J PAIN, V9, P883, DOI 10.1016/j.jpain.2008.05.005
  91. Veluchamy A, 2018, PAIN, V159, P825, DOI 10.1097/j.pain.0000000000001164
  92. Wolf EJ, 2019, PSYCHOL MED, V49, P791, DOI 10.1017/S0033291718001411
  93. Wolf EJ, 2018, PSYCHONEUROENDOCRINO, V92, P123, DOI 10.1016/j.psyneuen.2017.12.007
  94. Yan BC, 2011, J NEUROL SCI, V303, P100, DOI 10.1016/j.jns.2010.12.025
  95. Yorns WR, 2013, SEMIN PEDIATR NEUROL, V20, P188, DOI 10.1016/j.spen.2013.09.002
  96. Younger J, 2016, J WOMENS HEALTH, V25, P752, DOI 10.1089/jwh.2015.5509
  97. Zhao W, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173141

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Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/62