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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMONFORT-PIRES, Milena-
dc.contributor.authorU-DIN, Mueez-
dc.contributor.authorNOGUEIRA, Guilherme A.-
dc.contributor.authorALMEIDA-FARIA, Juliana de-
dc.contributor.authorSIDARTA-OLIVEIRA, Davi-
dc.contributor.authorSANT'ANA, Marcella Ramos-
dc.contributor.authorLIMA-JUNIOR, Jose C. de-
dc.contributor.authorCINTRA, Dennys E.-
dc.contributor.authorSOUZA, Heraldo Possolo de-
dc.contributor.authorFERREIRA, Sandra R. G.-
dc.contributor.authorSAPIENZA, Marcelo Tatit-
dc.contributor.authorVIRTANEN, Kirsi A.-
dc.contributor.authorVELLOSO, Licio A.-
dc.date.accessioned2021-06-17T13:50:31Z-
dc.date.available2021-06-17T13:50:31Z-
dc.date.issued2021-
dc.identifier.citationJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.106, n.2, p.472-484, 2021-
dc.identifier.issn0021-972X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/40559-
dc.description.abstractBackground: The brown adipose tissue (BAT) is a potential target for the treatment of obesity and metabolic disorders. Its activation by cold exposure or adrenergic drugs can increase systemic insulin sensitivity and improve lipid metabolism; however, little is known about the effects of specific dietary components on BAT activity. Objectives: We asked if a short-term (4 weeks) dietary intervention with olive oil could modify BAT activity in lean and overweight/obese volunteers. Design: This was a 4-week open clinical trial in which all participants underwent a dietary intervention with extra-virgin olive oil supplementation. As the initial intake of olive oil was controlled all the participants were controls of themselves. Results: The intervention resulted in significant increase in blood monounsaturated fatty acid levels, which was accompanied by increased BAT activity in lean but not in overweight/obese volunteers. In the lean group, an increase in leptin was detected after the intervention, and low leptin values at the beginning of the study were predictive of greater BAT activity after intervention. In addition, increase in leptin concentration was associated with increased BAT activity. Three known endogenous mediators of BAT activity, secretin, fibroblast growth factor 21 (FGF21), and 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) were increased by intervention in lean, whereas only secretin and FGF21 were increased in subjects with excessive weight. Conclusion: This study provides clinical evidence for the impact of monounsaturated fatty acids on BAT activity and an advance in the understanding of the beneficial health effects of olive oil.eng
dc.description.sponsorshipSao Paulo Research FoundationFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/076078, 2016/10616-7, 2018/05479-6, 2019/02055-3]-
dc.language.isoeng-
dc.publisherENDOCRINE SOCeng
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolism-
dc.rightsrestrictedAccesseng
dc.subjectOlive oileng
dc.subjectbrown adipose tissueeng
dc.subjectmetabolismeng
dc.subjectdietary interventioneng
dc.subjectsecretineng
dc.subjectleptineng
dc.subjectMUFAeng
dc.titleShort Dietary Intervention with Olive Oil Increases Brown Adipose Tissue Activity in Lean but not Overweight Subjectseng
dc.typearticleeng
dc.rights.holderCopyright ENDOCRINE SOCeng
dc.identifier.doi10.1210/clinem/dgaa824-
dc.identifier.pmid33180910-
dc.subject.wosEndocrinology & Metabolismeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalMONFORT-PIRES, Milena:State Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, BR-13084970 Sao Paulo, SP, Brazil-
hcfmusp.author.externalU-DIN, Mueez:Turku Univ Hosp, Turku PET Ctr, Turku 20520, Finland-
hcfmusp.author.externalNOGUEIRA, Guilherme A.:State Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, BR-13084970 Sao Paulo, SP, Brazil-
hcfmusp.author.externalALMEIDA-FARIA, Juliana de:State Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, BR-13084970 Sao Paulo, SP, Brazil-
hcfmusp.author.externalSIDARTA-OLIVEIRA, Davi:State Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, BR-13084970 Sao Paulo, SP, Brazil-
hcfmusp.author.externalSANT'ANA, Marcella Ramos:Univ Estadual Campinas, Nutr Genom Lab, LabGeN, Sch Appl Sci, BR-13484350 Sao Paulo, Brazil-
hcfmusp.author.externalLIMA-JUNIOR, Jose C. de:State Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, BR-13084970 Sao Paulo, SP, Brazil-
hcfmusp.author.externalCINTRA, Dennys E.:Univ Estadual Campinas, Nutr Genom Lab, LabGeN, Sch Appl Sci, BR-13484350 Sao Paulo, Brazil-
hcfmusp.author.externalFERREIRA, Sandra R. G.:Univ Sao Paulo, Dept Epidemiol, Sch Publ Hlth, BR-01246904 Sao Paulo, SP, Brazil-
hcfmusp.author.externalVIRTANEN, Kirsi A.:Turku Univ Hosp, Turku PET Ctr, Turku 20520, Finland; Univ Eastern Finland UEF, Inst Publ Hlth & Clin Nutr, Clin Nutr, Kuopio 70210, Finland-
hcfmusp.author.externalVELLOSO, Licio A.:State Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, BR-13084970 Sao Paulo, SP, Brazil-
hcfmusp.description.beginpage472-
hcfmusp.description.endpage484-
hcfmusp.description.issue2-
hcfmusp.description.volume106-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000759115900022-
hcfmusp.origem.id2-s2.0-85100361932-
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hcfmusp.publisher.countryUSAeng
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dc.identifier.eissn1945-7197-
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hcfmusp.scopus.lastupdate2022-06-30-
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