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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SABA, Esber S. | - |
dc.contributor.author | GUEYFFIER, Lucie | - |
dc.contributor.author | DICHTEL-DANJOY, Marie-Laure | - |
dc.contributor.author | POZZETTO, Bruno | - |
dc.contributor.author | BOURLET, Thomas | - |
dc.contributor.author | GUEYFFIER, Francois | - |
dc.contributor.author | MEKKI, Yahia | - |
dc.contributor.author | POTTEL, Hans | - |
dc.contributor.author | SABINO, Ester C. | - |
dc.contributor.author | VANHEMS, Philippe | - |
dc.contributor.author | ZREIN, Maan A. | - |
dc.date.accessioned | 2014-01-28T22:22:11Z | - |
dc.date.available | 2014-01-28T22:22:11Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | PLOS ONE, v.8, n.9, article ID e74493, 7p, 2013 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/4084 | - |
dc.description.abstract | Cross-reactive antibodies are characterized by their recognition of antigens that are different from the trigger immunogen. This happens when the similarity between two different antigenic determinants becomes adequate enough to enable a specific binding with such cross-reactive antibodies. In the present manuscript, we report the presence, at an ""abnormal"" high frequency, of antibodies in blood samples from French human subjects cross-reacting with a synthetic-peptide antigen derived from a Trypanosoma cruzi (T. cruzi) protein sequence. As the vector of T. cruzi is virtually confined to South America, the parasite is unlikely to be the trigger immunogen of the cross-reactive antibodies detected in France. At present, the cross-reactive antibodies are measured by using an in-house ELISA method that employs the T. cruzi -peptide antigen. However, to underline their cross-reactive characteristics, we called these antibodies ""Trypanosoma cruzi Cross Reactive Antibodies"" or TcCRA. To validate their cross-reactive nature, these antibodies were affinity-purified from plasma of healthy blood donor and were then shown to specifically react with the T. cruzi parasite by immunofluorescence. Seroprevalence of TcCRA was estimated at 45% in serum samples of French blood donors while the same peptide-antigen reacts with about 96% of T. cruzi -infected Brazilian individuals. In addition, we compared the serology of TcCRA to other serologies such as HSV 1/2, EBV, HHV-6, CMV, VZV, adenovirus, parvovirus B19, mumps virus, rubella virus, respiratory syncytial virus, measles and enterovirus. No association was identified to any of the tested viruses. Furthermore, we tested sera from different age groups for TcCRA and found a progressive acquisition starting from early childhood. Our findings show a large seroprevalence of cross-reactive antibodies to a well-defined T. cruzi antigen and suggest they are induced by a widely spread immunogen, acquired from childhood. The etiology of TcCRA and their clinical relevance still need to be investigated. | - |
dc.description.sponsorship | Infynity Biomarkers | - |
dc.description.sponsorship | region Rhone Alpes | - |
dc.language.iso | eng | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.ispartof | Plos One | - |
dc.rights | openAccess | - |
dc.subject.other | chagas heart-disease | - |
dc.subject.other | parasite persistence | - |
dc.subject.other | autoimmune-disease | - |
dc.subject.other | infection | - |
dc.subject.other | autoantibodies | - |
dc.subject.other | cardiomyopathy | - |
dc.subject.other | pathogenesis | - |
dc.subject.other | proteins | - |
dc.title | Anti-Trypanosoma cruzi Cross-Reactive Antibodies Detected at High Rate in Non-Exposed Individuals Living in Non-Endemic Regions: Seroprevalence and Association to Other Viral Serologies | - |
dc.type | article | - |
dc.rights.holder | Copyright PUBLIC LIBRARY SCIENCE | - |
dc.identifier.doi | 10.1371/journal.pone.0074493 | - |
dc.identifier.pmid | 24069315 | - |
dc.subject.wos | Multidisciplinary Sciences | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SABA, Esber S.:InfYn Biomarkers, Ecully, France; Fac Med Jacques Lisfranc, GIMAP EA3064, Lab Bacteriol Virol, St Etienne, France | - |
hcfmusp.author.external | GUEYFFIER, Lucie:InfYn Biomarkers, Ecully, France | - |
hcfmusp.author.external | DICHTEL-DANJOY, Marie-Laure:InfYn Biomarkers, Ecully, France | - |
hcfmusp.author.external | POZZETTO, Bruno:Fac Med Jacques Lisfranc, GIMAP EA3064, Lab Bacteriol Virol, St Etienne, France | - |
hcfmusp.author.external | BOURLET, Thomas:Fac Med Jacques Lisfranc, GIMAP EA3064, Lab Bacteriol Virol, St Etienne, France | - |
hcfmusp.author.external | GUEYFFIER, Francois:UCBL Hosp Civils Lyon, Fac Med Rockefeller, Lyon, France | - |
hcfmusp.author.external | MEKKI, Yahia:UCBL Hosp Civils Lyon, Fac Med Rockefeller, Lyon, France | - |
hcfmusp.author.external | POTTEL, Hans:Katholieke Univ Leuven, Interdisciplinary Res Ctr, Kortrijk, Belgium | - |
hcfmusp.author.external | VANHEMS, Philippe:UCBL Hosp Civils Lyon, Fac Med Rockefeller, Lyon, France | - |
hcfmusp.author.external | ZREIN, Maan A.:InfYn Biomarkers, Ecully, France; UCBL Hosp Civils Lyon, Fac Med Rockefeller, Lyon, France | - |
hcfmusp.description.articlenumber | e74493 | - |
hcfmusp.description.issue | 9 | - |
hcfmusp.description.volume | 8 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84884245689 | - |
hcfmusp.origem.id | WOS:000324547300044 | - |
hcfmusp.publisher.city | SAN FRANCISCO | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 8 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - LIM/46 Artigos e Materiais de Revistas Científicas - LIM/52 Artigos e Materiais de Revistas Científicas - ODS/03 |
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