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Title: Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
Authors: PEZATO, RogerioBALSALOBRE, LeonardoLIMA, MilenaBEZERRA, Thiago F. P.VOEGELS, Richard L.GREGORIO, Luis CarlosSTAMM, Aldo CassolZELE, Thibaut van
Citation: JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, v.42, article ID 27, 5p, 2013
Abstract: This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOF
Departamento de Otorrinolaringologia e Oftalmologia - FM/MOF

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/32
LIM/32 - Laboratório de Otorrinolaringologia

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