Autologous blood salvage in cardiac surgery: clinical evaluation, efficacy and levels of residual heparin

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art_VIEIRA_Autologous_blood_salvage_in_cardiac_surgery_clinical_evaluation_2021.PDF (1.06 MB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2021
DOI
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Scopus
Web of Science
PubMed
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ELSEVIER
Autores
VIEIRA, Sergio Domingos
PERINI, Fernanda da Cunha Vieira
SOUSA, Luiz Carlos Bento de
BUFFOLO, Enio
CHACCUR, Paulo
ARRAIS, Magaly
Citação
HEMATOLOGY TRANSFUSION AND CELL THERAPY, v.43, n.1, p.1-8, 2021
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Objective: Intraoperative blood salvage (cell saver technique) in cardiac surgery is universally used in surgical procedures with a marked risk of blood loss. The primary objectives of this study were to determine the concentration of residual heparin in the final product that is reinfused into the patient in the operating room and to evaluate the efficacy and safety of the cell saver technique. Method: Twelve patients undergoing elective cardiac surgery were enrolled in this study. Using the XTRA Autotransfusion System, blood samples were collected from the cardiotomy reservoir, both prior to blood processing (pre-sample) and after it, directly from the bag with processed product (post-sample). Hematocrit and hemoglobin levels, the protein, albumin and residual heparin concentrations, hemolysis index, and the platelet, erythrocyte and leukocyte counts were measured. Results: Hematocrit and hemoglobin levels and red blood cell counts were higher in post-processing samples, with a mean variation of 54.78%, 19.81 g/dl and 6.84 x 10(6)/mm(3), respectively (p < 0.001). The mean hematocrit of the processed bag was 63.49 g/dl (range: 57.2-67.5). The residual heparin levels were <= 0.1 IU/ml in all post-treatment analyses (p = 0.003). No related adverse events were observed. Conclusion: The reduced residual heparin values (<= 0.1 IU/ml) in processed blood found in this study are extremely important, as they are consistent with the American Association of Blood Banks guidelines, which establish target values below 0.5 IU/ml. The procedure was effective, safe and compliant with legal requirements and the available international literature. (C) 2019 Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular.
Palavras-chave
Intraoperative blood salvage, Autotransfusion, Residual heparin, Cell saver technique
URI
https://observatorio.fm.usp.br/handle/OPI/42152
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/11
Artigos e Materiais de Revistas Científicas - ODS/07