The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes

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art_NETO_The_Immunometabolic_Roles_of_Various_Fatty_Acids_in_2021.PDF (9.1 MB)
Citações na Scopus
17
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
CALDER, Philip C.
CURI, Rui
NEWSHOLME, Philip
SETHI, Jaswinder K.
SILVEIRA, Loreana S.
Citação
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, n.16, article ID 8460, 16p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research.
Palavras-chave
immune cells, lipids, fatty acids, metabolism, leukocytes, macrophages, lymphocytes, inflammation, cytokines
URI
https://observatorio.fm.usp.br/handle/OPI/42614
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