https://observatorio.fm.usp.br/handle/OPI/47011
Title: | Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study-ELSA-Brasil |
Authors: | BENSENOR, Isabela M.; GOULART, Alessandra C.; PEREIRA, Alexandre C.; BRUNONI, Andre R.; ALENCAR, Airlane; SANTOS, Raul D.; BITTENCOURT, Marcio S.; TELLES, Rosa W.; MACHADO, Luciana Andrade Carneiro; BARRETO, Sandhi Maria; ALMEIDA-PITITTO, Bianca de; JANOVSK, Carolina Porto Silva; SGARBI, Jose Augusto; TEBAR, William R.; MENEGHINI, Vandrize; JUNIOR, Fernando Barbosa; RIBEIRO, Ana Cristina de Medeiros; PASOTO, Sandra Gofinet; PEREIRA, Rosa Maria R.; BONFA, Eloisa; SIPAHI, Aytan M.; SANTOS, Itamar de S.; LOTUFO, Paulo A. |
Citation: | CLINICS, v.77, article ID 100013, 7p, 2022 |
Abstract: | Objectives: This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods: A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results: The high-risk group (n = 2,949; aged 53.6 +/- 9.2; 65.5% women) and the ACS (n=1543; 52.2 +/- 8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions: The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MCP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - HU Artigos e Materiais de Revistas Científicas - LIM/07 Artigos e Materiais de Revistas Científicas - LIM/13 Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - LIM/20 Artigos e Materiais de Revistas Científicas - LIM/27 Artigos e Materiais de Revistas Científicas - LIM/51 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_BENSENOR_Chronic_inflammatory_diseases_subclinical_atherosclerosis_and_cardiovascular_diseases_2022.PDF | publishedVersion (English) | 537.91 kB | Adobe PDF | View/Open |
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