Physical exercise attenuates obesity development in Western-diet fed obese rats independently of vitamin D supplementation

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art_CORDEIRO_Physical_exercise_attenuates_obesity_development_in_Westerndiet_fed_2022.PDF (1.81 MB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
CORDEIRO, Maiara Mikuska
RIBEIRO, Rosane Aparecida
BUBNA, Patricia Biscaia
ALMEIDA, Any Caroline de
FRANCO, Gilson Cesar Nobre
SCOMPARIN, Dionizia Xavier
Citação
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, v.49, n.6, p.633-642, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Physical inactivity, associated with the ingestion of hypercaloric foods, contributes to obesity development. In contrast, physical exercise training (ET) can slow obesity progression. Vitamin (Vit) D, a hormone that regulates adipocyte metabolism, may represent a strategy to reduce obesity; however, it is currently not known whether Vit D enhances the anti-obesity benefits of physical exercise. We hypothesized that swimming ET may prevent Western diet (WD)-induced obesity, and that Vit D supplementation could enhance the anti-obesity actions of ET. Male Wistar rats were fed, from 21 to 90 days of age, on a standard diet, or a WD, in association or not (sedentary control [CTL-SED] and WD [WD-SED] groups) with swimming ET for 15 min/day, 3 days a week (exercised CTL [CTL-EXE] and WD [WD-EXE] groups). Additionally, at 60 days of age, half of the CTL-EXE and WD-EXE groups were submitted, or not, to oral Vit D supplementation (CTL-EXE-VD and WD-EXE-VD groups, respectively). At 91 days old, WD-SED rats displayed increased body weight, abdominal adiposity, hypercholesterolemia, hyperleptinaemia and high circulating levels of tumour necrosis factor (TNF)-alpha. Swimming ET attenuated the increase in abdominal adiposity induced by WD. Furthermore, the WD-EXE group exhibited reductions in glycaemia, triglyceridaemia, cholesterolaemia, leptinaemia and in plasma TNF-alpha concentrations. Vitamin D supplementation, combined with ET, did not provide any additive benefit against adiposity, only potentiating the effects of ET action on the reduction in triglyceridaemia. Exercise training, independently of Vit D, provides a strategy to attenuate the adiposity expansion that is induced by WD, mediated in part by reductions in leptinaemia and TNF-alpha levels.
Palavras-chave
adipokines, cholecalciferol, exercise training, obesity, swimming, Western diet
URI
https://observatorio.fm.usp.br/handle/OPI/47285
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - ODS/03