Functional Changes in Cortical Activity of Patients Submitted to Knee Osteoarthritis Treatment An Exploratory Pilot Study

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art_IUAMOTO_Functional_Changes_in_Cortical_Activity_of_Patients_Submitted_2022.PDF (1.03 MB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
FREGNI, Felipe
Citação
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v.101, n.10, p.920-930, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction There is evidence that brain plasticity is the central mechanism involved in the functional recovery process of patients with knee osteoarthritis. Studies involving the analysis of central nervous system mechanisms of pain control and recovery could provide more data on future therapeutic approaches. Objective The aim of the study was to explore possible functional changes in cortical activity of patients submitted to knee osteoarthritis standardized pain treatment using electroencephalography. Methodology Ten patients with clinical and radiological diagnosis of painful knee unilateral or bilateral osteoarthritis were recruited to participate in clinical (Pain's Visual Analog Scale), radiological (Kellgren-Lawrence Scale), and neurophysiological (electroencephalography) assessments to evaluate cortical activity during cortical pain modulation activity. The clinical and neurophysiological analyses were performed before and after standardized pain treatment. Results Eight patients participated in this study. A significant improvement in pain perception and relative increase in interhemispheric connectivity after therapies was observed. In electroencephalography analysis, tests with real movement showed a relative increase in density directed at Graph's analysis. Conclusions Relative increase density directed measures at connectivity analysis in electroencephalography after pain treatment can be possible parameters to be explored in future research with a larger number of patients.
Palavras-chave
Osteoarthritis, Knee, Chronic Pain, Pain Perception, Neuronal Plasticity, Electroencephalography, Brain Connectivity, Cerebral Cortex
URI
https://observatorio.fm.usp.br/handle/OPI/49256
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MLS
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IMREA
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - LIM/37
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