Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

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art_LEANCA_Metabolism_of_plasma_cholesterol_and_lipoprotein_parameters_are_2013.PDF (193.58 KB)
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
PANZOLDO, Natalia B.
ZAGO, Vanessa S.
PARRA, Eliane S.
JAUHIAINEN, Matti
FARIA, Eliana C. de
Citação
CARDIOVASCULAR DIABETOLOGY, v.12, article ID 173, 7p, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.
Palavras-chave
Insulin resistance, HDL-C concentration, Lipoprotein lipases, Lecithin cholesterol acyl transferase, Pre-beta1 HDL, Plasma cholesterol metabolism markers, Cholesteryl ester transfer protein, Phospholipid transfer protein
URI
https://observatorio.fm.usp.br/handle/OPI/5074
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/10
Artigos e Materiais de Revistas Científicas - ODS/03