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https://observatorio.fm.usp.br/handle/OPI/5075
Título: | Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees |
Autor: | SANTOS, Keity Souza; STEPHANO, Marco Antonio; MARCELINO, Jose Roberto; FERREIRA, Virginia Maria Resende; ROCHA, Thalita; CARICATI, Celso; HIGASHI, Hisako Gondo; MORO, Ana Maria; KALIL, Jorge Elias; MALASPINA, Osmar; CASTRO, Fabio Fernandes Morato; PALMA, Mario Sergio |
Citación: | PLOS ONE, v.8, n.11, article ID e79971, 10p, 2013 |
Resumen: | Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)'(2)-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/19 Artigos e Materiais de Revistas Científicas - LIM/60 |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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art_SANTOS_Production_of_the_First_Effective_Hyperimmune_Equine_Serum_2013.PDF | publishedVersion (English) | 800.7 kB | Adobe PDF | Visualizar/Abrir |
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