Gamma Knife Surgery: Clinical Results

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2016
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WILEY BLACKWELL
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Lopes, A. C.; Batistuzzo, M.; Gentil, A. F.; Hoexter, M. Q.; Miguel, E. C.. Gamma Knife Surgery: Clinical Results. In: . NEUROMODULATION IN PSYCHIATRY: WILEY BLACKWELL, 2016. p.369-383.
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Albeit a traditional ablative procedure, Gamma Knife radiosurgery continues to be indicated for some severe and otherwise untreatable psychiatric disorders, especially obsessive-compulsive disorder. The majority of studies published so far have used lesions at the anterior limb of the internal capsule and consisted of case series. However, a placebo-controlled, double-blind randomized trial was recently published. Symptom improvements have been described in 25-80% of patients, suggesting that it is probably as efficacious as deep brain stimulation. Refinements of the radiosurgical techniques have allowed to lesion smaller volumes of white matter tissue, and thus a decreased incidence of severe adverse events has been reported. Nevertheless, aberrant radionecrotic reactions, such as brain cysts, are sporadically observed in a long-term follow-up. © 2016 John Wiley & Sons, Ltd. All rights reserved.
Palavras-chave
Mental disorders, Neurosurgical procedures, Obsessive-compulsive disorder, Psychiatric somatic therapies, Radiosurgery, Stereotaxic techniques
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