Vitamin A and Beta-Carotene Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy

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art_SEGURADO_Vitamin_A_and_Beta_Carotene_Concentrations_in_Adults_2013.PDF (462.34 KB)
Citações na Scopus
6
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CENTER ACADEMIC PUBL JAPAN
Autores
KAIO, Daniella Junko
RONDO, Patricia Helen Carvalho
SOUZA, Jose Maria Pacheco
FIRMINO, Aline Vale
LUZIA, Liania Alves
Citação
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, v.59, n.6, p.496-502, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Micronutrient deficiency is a common condition in HIV-infected individuals and may occur in all stages of the disease. The objective of this cross-sectional study was to compare the concentrations of vitamin A and beta-carotene, micronutrients related to immunity and oxidative stress, in 182 adults with HIV/AIDS, under different highly active antiretroviral therapy (HAART) regimens. Patients were divided into 3 groups according to their HAART regimen: combination of nucleoside analog reverse transcriptase inhibitors (NRTIs) and non-NRTIs; combination of NRTIs, protease inhibitors, and ritonavir; combination of NRTIs and other classes. Multiple linear regression analysis determined the effect of the treatment regimen, time of use, and compliance with the regimen, on vitamin A and beta-carotene concentrations, controlling for the following variables: gender, age, educational level, smoking, physical activity, body mass index, time of infection with HIV, presence of comorbidities, CD4(+) T lymphocyte count, total cholesterol and fractions, and triglyceride levels. There was no significant difference in vitamin A or beta-carotene concentrations in patients under the different HAART regimens. However, approximately 4% of the patients had deficient/low concentrations of vitamin A (<0.70 mu mol/L), and 98% showed concentrations of beta-carotene <1.0 mu mol/L. In conclusion, HIV/AIDS patients in this region will not benefit from vitamin A supplementation, independently of the HAART regimen utilized, but beta-carotene may be of importance, considering its antioxidant effect.
Palavras-chave
HIV infection, HAART, vitamin A, beta-carotene, micronutrients
URI
https://observatorio.fm.usp.br/handle/OPI/5130
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - ODS/03