Impact of hormone therapy on the bone density of women with premature ovarian insufficiency: A systematic review

Imagem de Miniatura
Arquivos
art_COSTA_Impact_of_hormone_therapy_on_the_bone_density_2023.PDF (687.67 KB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER IRELAND LTD
Autores
Citação
MATURITAS, v.167, p.105-112, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction: Women with premature ovarian insufficiency (POI) are exposed to a long period of estrogenic deficiency, which potentially brings higher health risks, especially regarding bone health. We performed a systematic review of the literature to evaluate the effect of hormone therapy (HT) on bone mineral density (BMD) in women with POI.Materials and methods: A systematic search was performed of the MEDLINE and EMBASE databases up to September 2021. We included studies that analyzed women with idiopathic (spontaneous) POI treated with HT, and those who had BMD evaluated. Analysis of risk of bias of studies selected was performed.Results: We found 335 articles and selected 16 studies according to the inclusion criteria. Most of the studies revealed lower bone density in both the femoral neck and lumbar spine of women with POI compared with healthy women. Bone mass had the tendency to remain stable in women treated with estrogen + progestin therapy. However, in women already with bone mass loss, the therapy -in the doses most frequently used -was not able to revert the loss. Higher doses of estrogen seem to have a positive impact on BMD, as did combined oral contraceptives used continuously. Also, the interruption of HT for longer than one year was linked to significant bone loss.Conclusion: Although HT brings clear benefits, further studies are needed to establish its long-term effects, as well as doses and formulations with better protective effects on the bone mass of these women.
Palavras-chave
Primary ovarian insufficiency, Bone density, Estrogen replacement therapy
URI
https://observatorio.fm.usp.br/handle/OPI/51557
Referências
  1. Amarante F, 2011, BRAZ J MED BIOL RES, V44, P78, DOI [10.1590/S0100-879X2010007500122, 10.1590/S0100-879X2011000100012]
  2. Bachelot A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0164638
  3. Benetti-Pinto CL, 2015, MENOPAUSE, V22, P946, DOI 10.1097/GME.0000000000000445
  4. Blake GM, 2007, POSTGRAD MED J, V83, P509, DOI 10.1136/pgmj.2007.057505
  5. Butts SF, 2017, OBSTET GYNECOL, V129, pE134, DOI 10.1097/AOG.0000000000002044
  6. Cartwright B, 2016, J CLIN ENDOCR METAB, V101, P3497, DOI 10.1210/jc.2015-4063
  7. Crofton PM, 2010, CLIN ENDOCRINOL, V73, P707, DOI 10.1111/j.1365-2265.2010.03868.x
  8. Davies JH, 2005, ARCH DIS CHILD, V90, P373, DOI 10.1136/adc.2004.053553
  9. Gao B., 2019, ORTHOP J SPORT MED, V7, DOI [10.1177/2325967119S00132,2325967119S00132, DOI 10.1177/2325967119S00132,2325967119S00132]
  10. Gazarra LBC, 2020, MENOPAUSE, V27, P1110, DOI 10.1097/GME.0000000000001592
  11. Giraldo H, 2017, GYNECOL ENDOCRINOL, V33, P283, DOI 10.1080/09513590.2016.1257602
  12. Gokmen O, 1995, GYNECOL ENDOCRINOL, V9, P283
  13. Goswami D, 2005, HUM REPROD UPDATE, V11, P391, DOI 10.1093/humupd/dmi012
  14. Han JM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102295
  15. Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
  16. Kanj RV, 2018, J PEDIATR ADOL GYNEC, V31, P13, DOI 10.1016/j.jpag.2017.07.005
  17. Kok HS, 2006, J AM COLL CARDIOL, V47, P1976, DOI 10.1016/j.jacc.2005.12.066
  18. Lambrinoudaki I, 2021, MATURITAS, V147, P53, DOI 10.1016/j.maturitas.2020.11.004
  19. Luchini C, 2017, WORLD J META-ANAL, V5, P80, DOI 10.13105/wjma.v5.i4.80
  20. METKA M, 1992, FERTIL STERIL, V57, P37
  21. Mittal Monica, 2014, Post Reprod Health, V20, P104, DOI 10.1177/2053369114539151
  22. Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
  23. Nelson LM, 2009, NEW ENGL J MED, V360, P606, DOI 10.1056/NEJMcp0808697
  24. Panay N, 2020, CLIMACTERIC, V23, P426, DOI 10.1080/13697137.2020.1804547
  25. Lana MBP, 2010, GYNECOL ENDOCRINOL, V26, P755, DOI 10.3109/09513590.2010.487599
  26. Podfigurna A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9123961
  27. Popat VB, 2014, J CLIN ENDOCR METAB, V99, P3418, DOI 10.1210/jc.2013-4145
  28. Popat VB, 2009, J CLIN ENDOCR METAB, V94, P2277, DOI 10.1210/jc.2008-1878
  29. Rossouw JE, 2007, JAMA-J AM MED ASSOC, V297, P1465, DOI 10.1001/jama.297.13.1465
  30. Rossouw JE, 2002, JAMA-J AM MED ASSOC, V288, P321, DOI 10.1001/jama.288.3.321
  31. Tella SH, 2014, J STEROID BIOCHEM, V142, P155, DOI 10.1016/j.jsbmb.2013.09.008
  32. Uygur Dilek, 2005, Archives of Gynecology and Obstetrics, V273, P17, DOI 10.1007/s00404-005-0029-7
  33. Webber L, 2016, HUM REPROD, V31, P926, DOI 10.1093/humrep/dew027
  34. Webber L, 2017, HUM REPROD OPEN, V2017, DOI 10.1093/hropen/hox007
  35. Wells P.T.G.A., 2014, NEWCASTLE OTTAWA SCA

Coleções
Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/58
Artigos e Materiais de Revistas Científicas - ODS/03