Clinical neurotransplantation protocol for Huntington's and Parkinson's disease

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art_LOPEZ_Clinical_neurotransplantation_protocol_for_Huntington_s_and_Parkinson_2013.PDF (1.02 MB)
Citações na Scopus
11
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
IOS PRESS
Autores
NIKKHAH, Guido
KAHLERT, Ulf D.
MACIACZYK, Donata
BOGIEL, Tomasz
MOELLERS, Sven
SCHUELTKE, Elisabeth
DOEBROESSY, Mate
MACIACZYK, Jaroslaw
Citação
RESTORATIVE NEUROLOGY AND NEUROSCIENCE, v.31, n.5, p.579-595, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose: The concept of transplantation of neuronal cells to treat Huntington's and Parkinson's diseases is based on the proven principle that dopaminergic and GABA-ergic progenitor neurons (from the human developing ventral mesencephalon and whole ganglionic eminence) can survive, differentiate and functionally integrate into an allogenic host brain. However, several donor and host-specific variables play a major role in the safety and outcome of this procedure. In this paper, we seek to summarize an updated neural transplantation protocol, based on our institutional experience and many years of collaboration with other neurotransplantation centers. Methods: We present a detailed clinical neurotransplantation protocol for Parkinson's (PD) and Huntington's (HD) diseases with special emphasis in understanding the anatomical relationships of the human fetal tissue that are relevant for selection of the desired cell populations. Results: Two detailed step-wise neurotransplantation protocols are presented, outlining strategies facilitating the avoidance of possible procedure-related complications. Conclusions: In this paper we delineated some crucial technical factors enabling the execution of a safe and effective neural transplantation. The protocols presented here might contribute to further development of the experimental clinical neurotransplantation towards a routine therapeutic procedure.
Palavras-chave
Human fetal neural precursor cells (hFNPCs), neural stem cells (NSC), ventral mesencephalon (VM), whole ganglionic eminence (WGE), substantia nigra (SN), Parkinson's disease (PD), Huntington's disease (HD), good clinical practice (GCP)
URI
https://observatorio.fm.usp.br/handle/OPI/5196
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros