Homocysteine is associated with higher risks of ischemic stroke: A systematic review and meta-analysis

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art_RABELO_Homocysteine_is_associated_with_higher_risks_of_ischemic_.PDF (2.97 MB)
Citações na Scopus
11
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
PUBLIC LIBRARY SCIENCE
Autores
NASCIMENTO, Rafaela Farias Vidigal
Citação
PLOS ONE, v.17, n.10, article ID e0276087, 20p, 2022
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Background High levels of homocysteine (Hct) have been associated with great risks of ischemic stroke. However, some controversy still exists. We performed a systematic review and meta-analysis to compare the levels of Hct between patients with ischemic stroke and controls. Methods We performed a systematic literature search for articles reporting Hct levels of patients with occurrence of ischemic stroke. We employed a random-effects inverse-variance weighted meta-analytical approach in order to pool standardized mean differences, with estimation of tau(2) through the DerSimonian-Laird method. Results The initial search yielded 1361 studies. After careful analysis of abstracts and full texts, the meta-analysis included data from 38 studies, which involved almost 16 000 stroke events. However, only 13 studies reported means and standard deviations for cases and controls, and therefore were used in the meta-analysis. Those studies presented data from 5002 patients with stroke and 4945 controls. Standardized mean difference was 1.67 (95% CI 1.00-2.25, P < 0.01), indicating that Hct levels were significantly larger in patients with ischemic stroke compared to controls. Between-study heterogeneity was very large (I-2 = 99%), particularly because three studies showed significantly large mean differences. Conclusion This meta-analysis shows that patients with ischemic stroke have higher levels of Hct compared to controls. Whether this is a modifiable risk factor remains to be assessed through larger prospective cohorts.
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URI
https://observatorio.fm.usp.br/handle/OPI/52986
Referências
  1. Acampa M, 2016, J STROKE, V18, P157, DOI 10.5853/jos.2015.01599
  2. Acampa M, 2011, CLIN TRANSPLANT, V25, P119, DOI 10.1111/j.1399-0012.2009.01126.x
  3. ARAKI A, 1989, ATHEROSCLEROSIS, V79, P139, DOI 10.1016/0021-9150(89)90118-4
  4. Ashjazadeh N, 2013, IRAN J MED SCI, V38, P233
  5. Bayir A, 2010, NEUROL RES, V32, P115, DOI 10.1179/016164109X12445616596201
  6. Beyan C, 2013, CLIN NEPHROL, V80, P311, DOI 10.5414/CN108055
  7. Biswas A, 2009, J STROKE CEREBROVASC, V18, P103, DOI 10.1016/j.jstrokecerebrovasdis.2008.09.014
  8. Bokhari FA, 2012, TRANSL NEUROSCI, V3, P41, DOI 10.2478/s13380-012-0005-1
  9. Bots ML, 1999, ARCH INTERN MED, V159, P38, DOI 10.1001/archinte.159.1.38
  10. BOUSHEY CJ, 1995, JAMA-J AM MED ASSOC, V274, P1049, DOI 10.1001/jama.274.13.1049
  11. Chambers JC, 2000, LANCET, V355, P523, DOI 10.1016/S0140-6736(99)93019-2
  12. Chen JJ, 2017, CELL MOL NEUROBIOL, V37, P1399, DOI 10.1007/s10571-017-0470-8
  13. Cotlarciuc I, 2014, STROKE, V45, P1920, DOI 10.1161/STROKEAHA.114.005208
  14. Dai DP, 2019, ANN NUTR METAB, V75, P9, DOI 10.1159/000501191
  15. Dhamija RK, 2009, J NEUROL SCI, V281, P64, DOI 10.1016/j.jns.2009.02.341
  16. Djuric D, 2018, CAN J PHYSIOL PHARM, V96, P991, DOI 10.1139/cjpp-2018-0112
  17. Evers S, 1997, ARCH NEUROL-CHICAGO, V54, P1276, DOI 10.1001/archneur.1997.00550220074017
  18. Fan YL, 2018, J AM SOC HYPERTENS, V12, P534, DOI 10.1016/j.jash.2018.03.011
  19. Folate, VIT B12 RISK ISCH HE
  20. Folsom AR, 1998, CIRCULATION, V98, P204, DOI 10.1161/01.CIR.98.3.204
  21. GENEST JJ, 1990, J AM COLL CARDIOL, V16, P1114, DOI 10.1016/0735-1097(90)90542-W
  22. Graham IM, 1997, JAMA-J AM MED ASSOC, V277, P1775, DOI 10.1001/jama.277.22.1775
  23. Gungor L, 2018, J STROKE CEREBROVASC, V27, P1921, DOI 10.1016/j.jstrokecerebrovasdis.2018.02.033
  24. Haapaniemi E, 2007, EUR J NEUROL, V14, P12, DOI 10.1111/j.1468-1331.2006.01518.x
  25. Hankey GJ, 2006, NAT CLIN PRACT NEURO, V2, P26, DOI 10.1038/ncpneuro0093
  26. He YS, 2014, NUTR METAB CARDIOVAS, V24, P1158, DOI 10.1016/j.numecd.2014.05.011
  27. Hogeveen M, 2002, J PEDIATR-US, V141, P429, DOI 10.1067/mpd.2002.126598
  28. HOPKINS PN, 1995, ARTERIOSCL THROM VAS, V15, P1314, DOI 10.1161/01.ATV.15.9.1314
  29. Hultdin J, 2011, CLIN CHEM LAB MED, V49, P1555, DOI 10.1515/CCLM.2011.234
  30. Iso H, 2004, CIRCULATION, V109, P2766, DOI 10.1161/01.CIR.0000131942.77635.2D
  31. Ji Y, 2013, NEUROLOGY, V81, P1298, DOI 10.1212/WNL.0b013e3182a823cc
  32. Joubran R, 1998, J Cardiovasc Risk, V5, P257, DOI 10.1097/00043798-199808000-00008
  33. Kalita J, 2009, CLIN NEUROL NEUROSUR, V111, P364, DOI 10.1016/j.clineuro.2008.12.010
  34. Kawamoto R, 2003, INTERNAL MED, V42, P571, DOI 10.2169/internalmedicine.42.571
  35. Kelly PJ, 2002, NEUROLOGY, V59, P529, DOI 10.1212/WNL.59.4.529
  36. Kelly PJ, 2004, STROKE, V35, P12, DOI 10.1161/01.STR.0000106481.59944.2F
  37. Kwon HM, 2014, STROKE, V45, P871, DOI 10.1161/STROKEAHA.113.004099
  38. Lehotsky J, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00538
  39. Li Y, 2017, NEUROL SCI, V38, P811, DOI 10.1007/s10072-017-2848-2
  40. Li ZH, 2003, STROKE, V34, P2085, DOI 10.1161/01.STR.0000086753.00555.0D
  41. LINDGREN A, 1995, STROKE, V26, P795, DOI 10.1161/01.STR.26.5.795
  42. Ling-Cong, 2018, REV ASSOC MED BRAS, V64, P438, DOI 10.1590/1806-9282.64.05.438
  43. Lu SS, 2018, BMC NEUROL, V18, DOI 10.1186/s12883-018-1203-4
  44. Ma YT, 2010, NEUROL RES, V32, P636, DOI 10.1179/016164109X12445616596445
  45. Macko Richard F, 2002, J Stroke Cerebrovasc Dis, V11, P1, DOI 10.1053/jscd.2002.123968
  46. Malinow MR., ATHEROSCLEROSIS, V126, P27
  47. Mansoor M, 1997, HEART, V77, P390, DOI 10.1136/hrt.77.4.390
  48. Mizrahi EH, 2005, ARCH PHYS MED REHAB, V86, P60, DOI 10.1016/j.apmr.2004.01.031
  49. Niazi F, 2019, CUREUS, V11, DOI 10.7759/cureus.5625
  50. Omrani HQ, 2011, ARYA ATHEROSCLER, V7, P97
  51. Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1016/j.ijsu.2021.105906]
  52. PANCHARUNITI N, 1994, AM J CLIN NUTR, V59, P940, DOI 10.1093/ajcn/59.4.940
  53. Peeters AC, 2007, J VASC SURG, V45, P701, DOI 10.1016/j.jvs.2006.12.019
  54. Peng H, 2000, J Tongji Med Univ, V20, P330
  55. Perini F, 2005, NEUROL SCI, V26, P310, DOI 10.1007/s10072-005-0505-7
  56. PERRY IJ, 1995, LANCET, V346, P1395, DOI 10.1016/S0140-6736(95)92407-8
  57. ROBINSON K, 1995, CIRCULATION, V92, P2825, DOI 10.1161/01.CIR.92.10.2825
  58. Rudreshkumar KJ, 2018, CLIN NUTR, V37, P1715, DOI 10.1016/j.clnu.2017.07.005
  59. Sawula W, 2009, CLIN BIOCHEM, V42, P442, DOI 10.1016/j.clinbiochem.2008.12.019
  60. Schwartz SM, 1997, CIRCULATION, V96, P412
  61. Shademan B, 2021, J CLIN LAB ANAL, DOI 10.1002/jcla.23996
  62. Shi ZH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25398-5
  63. Shi ZH, 2015, STROKE, V46, P2419, DOI 10.1161/STROKEAHA.115.009136
  64. Silberberg J, 1997, ATHEROSCLEROSIS, V133, P105, DOI 10.1016/S0021-9150(97)00122-6
  65. Song IU, 2009, J NEUROL SCI, V278, P60, DOI 10.1016/j.jns.2008.11.011
  66. Tang CZ, 2016, MOL NEUROBIOL, V53, P2152, DOI 10.1007/s12035-015-9186-2
  67. van Beynum IM, 1999, CIRCULATION, V99, P2070, DOI 10.1161/01.CIR.99.16.2070
  68. VERHOEF P, 1994, STROKE, V25, P1924, DOI 10.1161/01.STR.25.10.1924
  69. Verhoef P, 1996, AM J EPIDEMIOL, V143, P845, DOI 10.1093/oxfordjournals.aje.a008828
  70. VONECKARDSTEIN A, 1994, ARTERIOSCLER THROMB, V14, P460, DOI 10.1161/01.ATV.14.3.460
  71. Wald NJ., 2008, ARCH INTERN MED, V158, P862
  72. Wang CY, 2014, EUR J INTERN MED, V25, P538, DOI 10.1016/j.ejim.2014.04.011
  73. Wang HL, 2006, NEUROL RES, V28, P25, DOI 10.1179/016164106X91834
  74. Warsi AA, 2004, EUR J VASC ENDOVASC, V27, P75, DOI 10.1016/j.ejvs.2003.09.001
  75. Weikert C, 2007, STROKE, V38, P2912, DOI 10.1161/STROKEAHA.107.486068
  76. Wiebers D, 2003, LANCET, V362, P103, DOI 10.1016/S0140-6736(03)13860-3
  77. Wu GH, 2017, METAB BRAIN DIS, V32, P859, DOI 10.1007/s11011-017-9978-3
  78. Wu XY, 2020, NUTR METAB CARDIOVAS, V30, P1861, DOI 10.1016/j.numecd.2020.07.026
  79. Zhang T, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019467
  80. Zhou F, 2022, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.727418
  81. Zhou ZK, 2018, FRONT NEUROL, V9, DOI 10.3389/fneur.2018.01114

Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/09
Artigos e Materiais de Revistas Científicas - LIM/62
Artigos e Materiais de Revistas Científicas - ODS/03