Potentially inappropriate medications and cognitive performance: cross-sectional results from the ELSA-Brasil study

Imagem de Miniatura
Arquivos
art_SANTOS_Potentially_inappropriate_medications_and_cognitive_performance_crosssectional_results_2023.PDF (715.16 KB)
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
VIANA, Maria Carmen
Citação
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, v.79, n.7, p.927-934, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
ObjectivesPotentially inappropriate medications (PIM), especially those with potential effects on the central nervous system, can increase the risk of cognitive impairment. We investigated the association of the use of PIM and PIM that may impair cognition (PIM-Cog) with cognitive performance among older adults.MethodsIn this cross-sectional study with 2,626 participants, PIM and PIM-Cog were defined by the 2019 American Geriatrics Society Beers criteria. We calculated global cognition and memory, verbal fluency, and Trail Making Test B version (TMT-B) z-scores. Linear regression models adjusted for sociodemographic and clinical variables were used to investigate the association between PIM and cognition.Results27% and 7% of the sample (mean age = 65.1 +/- 4.1 years old, 54% women, and 61% White) used at least one PIM and PIM-cog, respectively. PIM was associated with poor performance in the TMT-B (beta = -0.17, 95% Cl = -0.29; -0.05, p = 0.007). PIM-Cog was also associated with poor TMT-B performance (beta = -0.08, 95% Cl = -0.15; -0.01, p = 0.025).ConclusionThe use of PIM and PIM-Cog was associated with poor executive function among older adults. The review of PIM use and the deprescription of these drugs may be an effective way to improve cognitive function.
Palavras-chave
Potentially, Inappropriate, Medication, Cognition, Dementia, Drug utilization
URI
https://observatorio.fm.usp.br/handle/OPI/54561
Referências
  1. Akiyama Haruhiko, 2011, Nihon Rinsho, V69 Suppl 10 Pt 2, P264
  2. Albuquerque EX, 2009, PHYSIOL REV, V89, P73, DOI 10.1152/physrev.00015.2008
  3. Aquino EML, 2012, AM J EPIDEMIOL, V175, P315, DOI 10.1093/aje/kwr294
  4. BEERS MH, 1991, ARCH INTERN MED, V151, P1825
  5. Berryman Sandra N, 2012, Medsurg Nurs, V21, P129
  6. Bertolucci PHF, 2001, ARQ NEURO-PSIQUIAT, V59, P532, DOI 10.1590/S0004-282X2001000400009
  7. Borja-Oliveira CR, 2015, ESTUD INTERDISCIP EN, V20, DOI [10.22456/2316-2171.38548, DOI 10.22456/2316-2171.38548]
  8. Borja-Oliveira CR, 2017, ESTUDOS INTERDISCIPL, V22, P57, DOI [10.22456/2316-2171.60273, DOI 10.22456/2316-2171.60273]
  9. Cacador C, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19052637
  10. Cai XY, 2013, ALZHEIMERS DEMENT, V9, P377, DOI 10.1016/j.jalz.2012.02.005
  11. Chor D, 2013, REV SAUDE PUBL, V47, P27, DOI 10.1590/S0034-8910.2013047003835
  12. Chuang Yi-Fang, 2017, Alzheimers Dement (N Y), V3, P471, DOI 10.1016/j.trci.2017.06.004
  13. Passos VMD, 2014, SAO PAULO MED J, V132, P170, DOI 10.1590/1516-3180.2014.1323646
  14. Fick DM, 2019, J AM GERIATR SOC, V67, P674, DOI 10.1111/jgs.15767
  15. Pitanga FJG, 2018, ARQ BRAS CARDIOL, V110, P36, DOI 10.5935/abc.20170178
  16. Gusmao L.C, 2017, GERIATR GERONTOL AGI, V10, P168, DOI [10.5327/Z2447-211520161600054, DOI 10.5327/Z2447-211520161600054]
  17. Hafdi M, 2020, J AM MED DIR ASSOC, V21, P188, DOI 10.1016/j.jamda.2019.05.010
  18. Iyer S, 2020, INT UROGYNECOL J, V31, P2653, DOI 10.1007/s00192-019-04140-3
  19. Kruger C, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-050344
  20. Maclagan LC, 2017, J AM GERIATR SOC, V65, P2205, DOI 10.1111/jgs.15016
  21. Mattay VS, 2008, BIOL PSYCHOL, V79, P9, DOI 10.1016/j.biopsycho.2008.03.015
  22. dos Santos ANM, 2020, REV BRAS ENFERM, V73, DOI 10.1590/0034-7167-2018-0324
  23. Nunes MA., 2011, REV HCPA, V31, P487
  24. O'Connor MN, 2012, DRUG AGING, V29, P437, DOI 10.2165/11632610-000000000-00000
  25. Passos Valéria Maria de Azeredo, 2018, Braz. J. Nephrol., V40, P18, DOI [10.1590/1678-4685-jbn-3889, 10.1590/1678-4685-JBN-3889]
  26. Radcliff S, 2015, J AM GERIATR SOC, V63, P2227, DOI 10.1111/jgs.13702
  27. Richardson K, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1315
  28. Santos Adriana Nancy Medeiros dos, 2018, Rev. bras. geriatr. gerontol., V21, P419, DOI 10.1590/1981-22562018021.170204
  29. Schmidt MI, 2015, INT J EPIDEMIOL, V44, P68, DOI 10.1093/ije/dyu027
  30. Sonnerstam E, 2017, EUR J CLIN PHARMACOL, V73, P735, DOI 10.1007/s00228-017-2218-2
  31. Stuss DT, 2002, ANNU REV PSYCHOL, V53, P401, DOI 10.1146/annurev.psych.53.100901.135220
  32. Ventura ALM, 2010, REV PSIQ CLIN-BRAZIL, V37, P66
  33. Zelazo PD, 2004, ACTA PSYCHOL, V115, P167, DOI 10.1016/j.actpsy.2003.12.005

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/22
Artigos e Materiais de Revistas Científicas - LIM/27
Artigos e Materiais de Revistas Científicas - LIM/51
Carregar mais