Influence of Serum Ferritin and B12 Levels in the Functional Outcomes of Patients with Ruptured and Unruptured Intracranial Aneurysms

Nenhuma Miniatura disponível
Citações na Scopus
Tipo de produção
article
Data de publicação
2023
DOI
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
GEORG THIEME VERLAG KG
Autores
BARBATO, Natalia Camargo
Citação
BRAZILIAN NEUROSURGERY-ARQUIVOS BRASILEIROS DE NEUROCIRURGIA, v.42, n.4, p.E309-E315, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction Pathological processes in the arterial wall that result in vessel dilation are the cause of intracranial aneurysms (IAs), and the risk factors for their formation and progression are not well established. Ferritin is associated with inflammation and angiogenesis; it has protective antioxidative activity, and controls cell differentiation. Vitamin B12 is related to neurological and hematological disorders; it can be used as differential diagnosis tool, and acts in the control of homocysteinemia, a predictor of worse prognosis. The present article aims to assess the correlation between serum ferritin and B12 levels and the patient's functional outcome.Materials and Methods In the present cohort study, we assessed the serum levels of ferritin and B12, as well as the scores on the modified Rankin and Glasgow Outcome Scales at 6 months, of 2 groups, one with 19 and the other with 49 individuals, out of 401 patients treated for IA at Universidade de Sao Paulo from 2018 to 2019. We performed a statistical analysis, using logistic regression, to determine the aforementioned correlation.Results In the univariable analysis, the serum levels of ferritin showed no significant impact on the functional outcome (odds ratio [OR]: 0.96 for every 100 pg/mL increase; 95% confidence interval [95%CI]: 0.761-1.210; p = 0.732); neither did the serum levels of B12 (OR: 0.998 for every 100 pg/mL increase; 95%CI: 0.826-1.206; p = 0.987). Moreover, no significant impact on the functional outcome was observed in the multivariable analysis regarding the serum levels of B12, age, hypertension, and aneurysm rupture (OR: 1.086 for every 100 pg/mL increase; 95%CI: 0.847-1.392; p = 0.513).Conclusion We were not able to confirm a statistical correlation regarding the serum levels of ferritin and B12, and functional outcome of IA patients. These variables might be linked to other determinants of the pathophysiology of IAs, like inflammation and homocysteinemia.
Palavras-chave
brain aneurysm, ruptured intracranial aneurysm, unruptured intracranial aneurysm, subarachnoid hemorrhage, serum ferritin, serum B12
URI
https://observatorio.fm.usp.br/handle/OPI/57972
Referências
  1. Ajiboye Norman, 2015, ScientificWorldJournal, V2015, P954954, DOI 10.1155/2015/954954
  2. Arosio P, 2017, IUBMB LIFE, V69, P414, DOI 10.1002/iub.1621
  3. Can A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-42622-y
  4. Cunha BA, 2010, HEART LUNG, V39, P164, DOI 10.1016/j.hrtlng.2009.06.007
  5. Czekajlo Anna, 2019, Rocz Panstw Zakl Hig, V70, P119, DOI 10.32394/rpzh.2019.0061
  6. Fu Y, 2018, BRIT J PHARMACOL, V175, P1173, DOI 10.1111/bph.13988
  7. Gáll T, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20153675
  8. Garcia-Casal MN, 2018, ARCH MED RES, V49, P405, DOI 10.1016/j.arcmed.2018.12.005
  9. Institute of Medicine (US), 1998, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline
  10. Kitagawa T, 2017, J MAGN RESON IMAGING, V45, P1144, DOI 10.1002/jmri.25459
  11. Knovich MA, 2009, BLOOD REV, V23, P95, DOI 10.1016/j.blre.2008.08.001
  12. Korja M, 2016, NEUROLOGY, V87, P1118, DOI 10.1212/WNL.0000000000003091
  13. Korja M, 2014, STROKE, V45, P1958, DOI 10.1161/STROKEAHA.114.005318
  14. Kotowski M, 2013, J NEUROL NEUROSUR PS, V84, P42, DOI 10.1136/jnnp-2011-302068
  15. Kumar A, 2017, NUTR METAB, V14, DOI 10.1186/s12986-017-0233-z
  16. Lindqvist M, 2012, AM J CARDIOVASC DIS, V2, P318
  17. Mwafy SN, 2018, HEMATOL TRANSF CELL, V40, P160, DOI 10.1016/j.htct.2017.11.010
  18. Naggara ON, 2012, RADIOLOGY, V263, P828, DOI 10.1148/radiol.12112114
  19. Nieuwkamp DJ, 2009, LANCET NEUROL, V8, P635, DOI 10.1016/S1474-4422(09)70126-7
  20. Oh RC, 2003, AM FAM PHYSICIAN, V67, P979
  21. Peeters AC, 2007, J VASC SURG, V45, P701, DOI 10.1016/j.jvs.2006.12.019
  22. Petzold A, 2011, J STROKE CEREBROVASC, V20, P489, DOI 10.1016/j.jstrokecerebrovasdis.2010.02.021
  23. Romain M, 2016, ANAESTH INTENS CARE, V44, P447, DOI 10.1177/0310057X1604400410
  24. Roohi J, 2017, J NUTR, V147, P1290, DOI 10.3945/jn.117.251173
  25. Rosi J, 2018, WORLD NEUROSURG, V119, pE272, DOI 10.1016/j.wneu.2018.07.132
  26. Schwaerzer GK, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11389-1
  27. Spark JI, 2003, EUR J VASC ENDOVASC, V26, P558, DOI 10.1016/S1078-5884(03)00381-2
  28. Takagi H, 2017, INT ANGIOL, V36, P21, DOI 10.23736/S0392-9590.16.03618-X
  29. Wang W, 2010, BBA-GEN SUBJECTS, V1800, P760, DOI 10.1016/j.bbagen.2010.03.011
  30. Warsi AA, 2004, EUR J VASC ENDOVASC, V27, P75, DOI 10.1016/j.ejvs.2003.09.001
  31. Zulfiqar AA, 2019, MEDICINA-BUENOS AIRE, V79, P391

Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/09
Artigos e Materiais de Revistas Científicas - LIM/62