Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure

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article
Data de publicação
2023
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ELSEVIER SCIENCE INC
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TRANSPLANTATION PROCEEDINGS, v.55, n.9, 2023
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Resumo
A new outbreak of hepatitis of unknown origin raised awareness in the international community. A few reports have attempted to associate new cases with adenovirus infection and the immunologic effects of previous SARS-CoV-2 infections through a superantigen mechanism. Moreover, according to a case series, viral isolates were identified in 7 of 10 cases of pediatric patients with hepatitis of unknown origin and acute liver failure. Adenovirus was detected by respiratory secretion polymerase chain reaction in 2 patients, with neither presenting with SARS-CoV-2 acute infection. Clinical and laboratory descriptions and cross-referencing epidemiologic and pathophysiological data can help identify possible disease etiologies.
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Referências
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