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https://observatorio.fm.usp.br/handle/OPI/1697
Título: | Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock |
Autor: | BARBEIRO, Denise Frediani; BARBEIRO, Hermes Vieira; ZAMPIERI, Fernando Godinho; MACHADO, Marcel Cerqueira Cesar; TORGGLER FILHO, Francisco; CUNHA, Debora Maria Gomes; GOULART, Alessandra Carvalho; VELASCO, Irineu Tadeu; CRUZ NETO, Luiz Monteiro da; SOUZA, Heraldo Possolo de; SILVA, Fabiano Pinheiro da |
Citación: | MICROBES AND INFECTION, v.15, n.5, p.342-346, 2013 |
Resumen: | Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection. LL-37 can protect against bacterial infections and possesses many immunomodulatory properties. Here, we show that the human host defense peptide LL-37 is down regulated during septic shock. Furthermore, we show that these effects are not related to vitamin D serum levels, a potent inducer of LL-37 gene expression, pointing out the complex regulation of cathelicidins during septic shock. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - FM/MCG Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/51 |
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art_BARBEIRO_Cathelicidin_LL_37_bloodstream_surveillance_is_down_regulated_2013.PDF Restricted Access | publishedVersion (English) | 213.6 kB | Adobe PDF | Visualizar/Abrir Request a copy |
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