Hypertension Severity Is Associated With Impaired Cognitive Performance
Carregando...
Citações na Scopus
66
Tipo de produção
article
Data de publicação
2017
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Citação
JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.6, n.1, article ID e004579, 10p, 2017
Resumo
Background-Most evidence of target-organ damage in hypertension (HTN) is related to the kidneys and heart. Cerebrovascular and cognitive impairment are less well studied. Therefore, this study analyzed changes in cognitive function in patients with different stages of hypertension compared to nonhypertensive controls. Methods and Results-In a cross-sectional study, 221 (71 normotensive and 150 hypertensive) patients were compared. Patients with hypertension were divided into 2 stages according to blood pressure (BP) levels or medication use (HTN-1: BP, 140-159/90-99 or use of 1 or 2 antihypertensive drugs; HTN-2: BP, >= 160/100 or use of >= 3 drugs). Three groups were comparatively analyzed: normotension, HTN stage 1, and HTN stage 2. The Mini-Mental State Examination, Montreal Cognitive Assessment, and a validated comprehensive battery of neuropsychological tests that assessed 6 main cognitive domains were used to determine cognitive function. Compared to the normotension and HTN stage-1, the severe HTN group had worse cognitive performance based on MiniMental State Examination (26.8 +/- 2.1 vs 27.4 +/- 2.1 vs 28.0 +/- 2.0; P= 0.004) or Montreal Cognitive Assessment (23.4 +/- 3.7 vs 24.9 +/- 2.8 vs 25.5 +/- 3.2; P< 0.001). On the neuropsychological tests, patients with hypertension had worse performance in language, processing speed, visuospatial abilities, and memory. Age, hypertension stage, and educational level were the best predictors of cognitive impairment in patients with hypertension in different cognitive domains. Conclusions-Cognitive impairment was more frequent in patients with hypertension, and this was related to hypertension severity.
Palavras-chave
cognition, cognitive impairment, high blood pressure, hypertension
Referências
- Antelmi I, 2008, ARQ BRAS CARDIOL, V90, P413, DOI 10.1590/S0066-782X2008000600005
- Aprahamian I, 2010, INT PSYCHOGERIATR, V22, P64, DOI 10.1017/S1041610209991141
- Axelrod BN, 2001, ARCH CLIN NEUROPSYCH, V16, P293, DOI 10.1016/S0887-6177(00)00048-2
- Bischkopf J, 2002, ACTA PSYCHIAT SCAND, V106, P403, DOI 10.1034/j.1600-0447.2002.01417.x
- Brucki SMD, 2003, ARQ NEURO-PSIQUIAT, V61, P777, DOI 10.1590/S0004-282X2003000500014
- Buffon F, 2006, J NEUROL NEUROSUR PS, V77, P175, DOI 10.1136/jnnp.2005.068726
- Carlson MDA, 2009, J PALLIAT MED, V12, P77, DOI 10.1089/jpm.2008.9690
- Chaves ML, 2009, J GERIATR PSYCH NEUR, V22, P181, DOI 10.1177/0891988709332942
- ELIAS MF, 1993, AM J EPIDEMIOL, V138, P353
- Evans DA, 1997, ARCH NEUROL-CHICAGO, V54, P1399
- FARMER ME, 1990, J CLIN EPIDEMIOL, V43, P475, DOI 10.1016/0895-4356(90)90136-D
- FARMER ME, 1987, AM J EPIDEMIOL, V126, P1103
- FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
- Fratiglioni L, 1999, DRUG AGING, V15, P365, DOI 10.2165/00002512-199915050-00004
- Frota Norberto Anízio Ferreira, 2011, Dement. neuropsychol., V5, P146, DOI 10.1590/S1980-57642011DN05030002
- Garrett Kelly Davis, 2004, Arch Clin Neuropsychol, V19, P745, DOI 10.1016/j.acn.2003.09.008
- Gorelick PB, 2011, STROKE, V42, P2672, DOI 10.1161/STR.0b013e3182299496
- Guo ZC, 1997, AM J EPIDEMIOL, V145, P1106
- Hachinski V, 2006, STROKE, V37, P2220, DOI 10.1161/01.STR.0000237236.88823.47
- Harrington F, 2000, HYPERTENSION, V36, P1079
- Hugo J, 2014, CLIN GERIATR MED, V30, P421, DOI 10.1016/j.cger.2014.04.001
- Iadecola C, 2013, NEURON, V80, P844, DOI 10.1016/j.neuron.2013.10.008
- Joffres M, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-003423
- KALRA L, 1993, J HUM HYPERTENS, V7, P285
- Kearney PM, 2005, LANCET, V365, P217, DOI 10.1016/S0140-6736(05)17741-1
- Kuo HK, 2004, J GERONTOL A-BIOL, V59, P1191
- LAUNER LJ, 1995, JAMA-J AM MED ASSOC, V274, P1846, DOI 10.1001/jama.274.23.1846
- Leung JLM, 2011, INT PSYCHOGERIATR, V23, P1569, DOI 10.1017/S1041610211000792
- Liu H, 2013, J AM GERIATR SOC, V61, P875, DOI 10.1111/jgs.12259
- Looi JCL, 1999, NEUROLOGY, V53, P670
- Luis CA, 2009, INT J GERIATR PSYCH, V24, P197, DOI 10.1002/gps.2101
- Malloy-Diniz LF, 2007, REV BRAS PSIQUIATR, V29, P324, DOI 10.1590/S1516-44462006005000053
- Memoria CM, 2013, INT J GERIATR PSYCH, V28, P34, DOI 10.1002/gps.3787
- Miotto EC, 2010, REV BRAS PSIQUIATR, V32, P279, DOI 10.1590/S1516-44462010005000006
- Nasreddine ZS, 2005, J AM GERIATR SOC, V53, P695, DOI 10.1111/j.1532-5415.2005.53221.x
- Ng A, 2013, SINGAP MED J, V54, P616
- O'Sullivan M, 2004, J NEUROL NEUROSUR PS, V75, P441, DOI 10.1136/jnnp.2003.014910
- Peters N, 2005, AM J PSYCHIAT, V162, P2078, DOI 10.1176/appi.ajp.162.11.2078
- Petersen RC, 1999, ARCH NEUROL-CHICAGO, V56, P303, DOI 10.1001/archneur.56.3.303
- Prencipe M, 1996, J NEUROL NEUROSUR PS, V60, P628, DOI 10.1136/jnnp.60.6.628
- Prince M, 2013, ALZHEIMERS DEMENT, V9, P63, DOI 10.1016/j.jalz.2012.11.007
- ROMAN GC, 1993, NEUROLOGY, V43, P250
- ROSEN W G, 1980, Journal of Clinical Neuropsychology, V2, P135, DOI 10.1080/01688638008403788
- Scarmeas Nikolaos, 2004, Curr Neurol Neurosci Rep, V4, P374, DOI 10.1007/s11910-004-0084-7
- Shin MS, 2006, NAT PROTOC, V1, P892, DOI 10.1038/nprot.2006.115
- Skoog I, 1996, LANCET, V347, P1141, DOI 10.1016/S0140-6736(96)90608-X
- Sociedade BDH, 2010, ARQ BRAS CARDIOL, V95, P1
- Stern Y, 2009, NEUROPSYCHOLOGIA, V47, P2015, DOI 10.1016/j.neuropsychologia.2009.03.004
- Strauss E, 2006, COMPENDIUM NEUROPSYC, P655
- Tierney MC, 2001, ARCH NEUROL-CHICAGO, V58, P1654, DOI 10.1001/archneur.58.10.1654
- Tombaugh TN, 1999, ARCH CLIN NEUROPSYCH, V14, P167, DOI 10.1016/S0887-6177(97)00095-4
- Traykov L, 2002, DEMENT GERIATR COGN, V14, P26, DOI 10.1159/000058330
- Tsivgoulis G, 2009, NEUROLOGY, V73, P589, DOI 10.1212/WNL.0b013e3181b38969
- Waldstein SR, 2005, HYPERTENSION, V45, P374, DOI 10.1161/01.HYP.0000156744.44218.74
- Waldstein SR, 2003, CURR DIR PSYCHOL SCI, V12, P9, DOI 10.1111/1467-8721.01212
- WILKIE F, 1971, SCIENCE, V172, P959, DOI 10.1126/science.172.3986.959
- Zahodne LB, 2011, J INT NEUROPSYCH SOC, V17, P1039, DOI 10.1017/S1355617711001044