https://observatorio.fm.usp.br/handle/OPI/22893
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | GUALANO, Bruno | - |
dc.contributor.author | PAINELLI, Vitor de Salles | - |
dc.contributor.author | ROSCHEL, Hamilton | - |
dc.contributor.author | LUGARESI, Rebeca | - |
dc.contributor.author | DOREA, Egidio | - |
dc.contributor.author | ARTIOLI, Guilherme Giannini | - |
dc.contributor.author | LIMA, Fernanda Rodrigues | - |
dc.contributor.author | SILVA, Maria Elizabeth Rossi da | - |
dc.contributor.author | CUNHA, Maria Rosaria | - |
dc.contributor.author | SEGURO, Antonio Carlos | - |
dc.contributor.author | SHIMIZU, Maria Heloisa | - |
dc.contributor.author | OTADUY, Maria Concepcion Garcia | - |
dc.contributor.author | SAPIENZA, Marcelo Tatit | - |
dc.contributor.author | LEITE, Claudia da Costa | - |
dc.contributor.author | BONFA, Eloisa | - |
dc.contributor.author | LANCHA JUNIOR, Antonio Herbert | - |
dc.date.accessioned | 2017-11-27T16:25:48Z | - |
dc.date.available | 2017-11-27T16:25:48Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v.111, n.5, p.749-756, 2011 | - |
dc.identifier.issn | 1439-6319 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/22893 | - |
dc.description.abstract | Creatine supplementation may have a therapeutic role in diabetes, but it is uncertain whether this supplement is safe for kidney function. The aim of this study was to investigate the effects of creatine supplementation on kidney function in type 2 diabetic patients. A randomized, double-blind, placebo-controlled trial was performed. The patients were randomly allocated to receive either creatine or placebo for 12 weeks. All the patients underwent exercise training throughout the trial. Subjects were assessed at baseline and after the intervention. Blood samples and 24-h urine samples were obtained for kidney function assessments. Additionally, (51)Cr-EDTA clearance was performed. To ensure the compliance with creatine intake, we also assessed muscle phosphorylcreatine content. The creatine group presented higher muscle phosphorylcreatine content when compared to placebo group (CR Pre 44 +/- A 10, Post 70 +/- A 18 mmol/kg/wt; PL Pre 52 +/- A 13, Post 46 +/- A 13 mmol/kg/wt; p = 0.03; estimated difference between means 23.6; 95% confidence interval 1.42-45.8). No significant differences were observed for (51)Cr-EDTA clearance (CR Pre 90.4 +/- A 16.9, Post 96.1 +/- A 15.0 mL/min/1.73 m(2); PL Pre 97.9 +/- A 21.6, Post 96.4 +/- A 26.8 mL/min/1.73 m(2); p = 0.58; estimated difference between means -0.3; 95% confidence interval -24.9 to 24.2). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria were unchanged. CR supplementation does not affect kidney function in type 2 diabetic patients, opening a window of opportunities to explore its promising therapeutic role in this population. ClinicalTrials.gov registration number: NCT00992043. | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico | - |
dc.language.iso | eng | - |
dc.publisher | SPRINGER | - |
dc.relation.ispartof | European Journal of Applied Physiology | - |
dc.rights | restrictedAccess | - |
dc.subject | Phosphorylcreatine | - |
dc.subject | Chronic kidney disease | - |
dc.subject | Diabetes | - |
dc.subject | Glomerular filtration rate | - |
dc.subject.other | renal-function | - |
dc.subject.other | term | - |
dc.subject.other | monohydrate | - |
dc.subject.other | rats | - |
dc.subject.other | failure | - |
dc.subject.other | disease | - |
dc.subject.other | muscle | - |
dc.title | Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial | - |
dc.type | article | - |
dc.rights.holder | Copyright SPRINGER | - |
dc.identifier.doi | 10.1007/s00421-010-1676-3 | - |
dc.identifier.pmid | 20976468 | - |
dc.subject.wos | Physiology | - |
dc.subject.wos | Sport Sciences | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | PAINELLI, Vitor de Salles:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sports, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Div Rheumatol, Sao Paulo, Brazil | - |
hcfmusp.author.external | ROSCHEL, Hamilton:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sports, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Div Rheumatol, Sao Paulo, Brazil | - |
hcfmusp.author.external | LUGARESI, Rebeca:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sports, Sao Paulo, Brazil | - |
hcfmusp.author.external | ARTIOLI, Guilherme Giannini:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sports, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Div Rheumatol, Sao Paulo, Brazil | - |
hcfmusp.author.external | CUNHA, Maria Rosaria:Univ Sao Paulo, Sch Med, Lab Med Investigat, Div Endocrinol, Sao Paulo, Brazil | - |
hcfmusp.author.external | LANCHA JUNIOR, Antonio Herbert:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sports, Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 749 | - |
hcfmusp.description.endpage | 756 | - |
hcfmusp.description.issue | 5 | - |
hcfmusp.description.volume | 111 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-79958769141 | - |
hcfmusp.origem.id | WOS:000289437900003 | - |
hcfmusp.publisher.city | NEW YORK | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 56 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InRad Artigos e Materiais de Revistas Científicas - HU Artigos e Materiais de Revistas Científicas - LIM/12 Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - LIM/18 Artigos e Materiais de Revistas Científicas - LIM/43 Artigos e Materiais de Revistas Científicas - LIM/44 |
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