Is cardiac tissue more susceptible than lung to oxidative effects induced by chronic nasotropic instillation of residual oil fly ash (ROFA)?

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art_DAMIANI_Is_cardiac_tissue_more_susceptible_than_lung_to_2012.PDF (998.58 KB)
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
INFORMA HEALTHCARE
Autores
DAMIANI, Roberto Marques
PIVA, Marcella Ody
PETRY, Marcelo Rafael
OLIVEIRA, Alexandre Tavares Duarte de
RHODEN, Claudia Ramos
Citação
TOXICOLOGY MECHANISMS AND METHODS, v.22, n.7, p.533-539, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The current study aimed to determine the role of oxidants in cardiac and pulmonary toxicities induced by chronic exposure to ROFA. Eighty Wistar rats were divided into four groups: G1 (10 mu L Saline), G2 (ROFA 50 mu g/10 mu L), G3 (ROFA 250 mu g/10 mu L) and G4 (ROFA 500 mu g/10 mu L). Rats received ROFA by nasotropic instillation for 90 days. After that, they were euthanized and bronchoalveolar lavage (BAL) was performed for total count of leukocytes, protein and lactate dehydrogenase (LDH) determinations. Lungs and heart were removed to measure lipid peroxidation (MDA), catalase (CAT) and superoxide dismutase (SOD) activity. BAL presented an increase in leukocytes count in G4 in comparison to the Saline group (p = 0.019). In lung, MDA level was not modified by ROFA, while CAT was higher in G4 when compared to all other groups (p = 0.013). In heart, G4 presented an increase in MDA (p = 0.016) and CAT (p = 0.027) levels in comparison to G1. The present study demonstrated cardiopulmonary oxidative changes after a chronic ROFA exposure. More specifically, the heart tissue seems to be more susceptible to oxidative effects of long-term exposure to ROFA than the lung.
Palavras-chave
ROFA, chronic exposure, air pollution, cardiopulmonary oxidative stress
URI
https://observatorio.fm.usp.br/handle/OPI/2573
Referências
  1. AEBI H, 1984, METHOD ENZYMOL, V105, P121
  2. Becker S, 2002, TOXICOL IN VITRO, V16, P209, DOI 10.1016/S0887-2333(02)00015-2
  3. BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1006/abio.1976.9999
  4. Calderon-Garciduenas L, 2001, TOXICOL SCI, V61, P356, DOI 10.1093/toxsci/61.2.356
  5. Dockery DW, 2001, ENVIRON HEALTH PERSP, V109, P483, DOI 10.2307/3454657
  6. DOCKERY DW, 1993, NEW ENGL J MED, V329, P1753, DOI 10.1056/NEJM199312093292401
  7. Frampton MW, 2001, ENVIRON HEALTH PERSP, V109, P529, DOI 10.2307/3454664
  8. Ghelfi E, 2008, TOXICOL SCI, V102, P328, DOI 10.1093/toxsci/kfn005
  9. Ghio AJ, 2002, ENVIRON HEALTH PERSP, V110, P89
  10. Gurgueira SA, 2002, ENVIRON HEALTH PERSP, V110, P749
  11. Halliwell B., 2007, FREE RADICALS BIOL M
  12. Imrich A, 2007, TOXICOL APPL PHARM, V218, P256, DOI 10.1016/j.taap.2006.11.033
  13. Jones RD, 2000, PHARMACOL THERAPEUT, V88, P153, DOI 10.1016/S0163-7258(00)00089-9
  14. KINNULA VL, 1995, LAB INVEST, V73, P3
  15. LOHMANNMATTHES ML, 1994, EUR RESPIR J, V7, P1678
  16. Maklund S, 1985, HDB METHODS OXYGEN R
  17. Matoba T, 2000, J CLIN INVEST, V106, P1521, DOI 10.1172/JCI10506
  18. Medeiros N, 2004, ENVIRON RES, V95, P62, DOI 10.1016/j.envres.2003.07.007
  19. Miller KA, 2007, NEW ENGL J MED, V356, P447, DOI 10.1056/NEJMoa054409
  20. Mills NL, 2007, NEW ENGL J MED, V357, P1075, DOI 10.1056/NEJMoa066314
  21. Oberdorster G, 2002, J TOXICOL ENV HEAL A, V65, P1531, DOI 10.1080/00984100290071658
  22. OBERDORSTER G, 1992, ENVIRON HEALTH PERSP, V97, P193, DOI 10.2307/3431353
  23. Pereira CEL, 2007, BRAZ J MED BIOL RES, V40, P1353, DOI 10.1590/S0100-879X2006005000164
  24. POPE CA, 1992, ARCH ENVIRON HEALTH, V47, P211
  25. Puett RC, 2008, AM J EPIDEMIOL, V168, P1161, DOI 10.1093/aje/kwn232
  26. Rahman I, 2006, EUR J PHARMACOL, V533, P222, DOI 10.1016/j.ejphar.2005.12.087
  27. Rhoden CR, 2005, BBA-GEN SUBJECTS, V1725, P305, DOI 10.1016/j.bbagen.2005.05.025
  28. Rhoden CR, 2004, TOXICOL SCI, V79, P296, DOI 10.1093/toxsci/kfh122
  29. Rhoden CR, 2008, INHAL TOXICOL, V20, P11, DOI 10.1080/08958370701758379
  30. Rivero DHRF, 2005, TOXICOL SCI, V85, P898, DOI 10.1093/toxsci/kfi137
  31. Ruan T, 2003, J APPL PHYSIOL, V94, P1987, DOI 10.1152/japplphysiol.01047.2002
  32. SALDIVA PHN, 1995, ARCH ENVIRON HEALTH, V50, P159
  33. Scandalios JG, 2005, BRAZ J MED BIOL RES, V38, P995, DOI 10.1590/S0100-879X2005000700003
  34. Sun QH, 2005, JAMA-J AM MED ASSOC, V294, P3003, DOI 10.1001/jama.294.23.3003
  35. Suvorava T, 2009, BBA-BIOENERGETICS, V1787, P802, DOI 10.1016/j.bbabio.2009.04.005
  36. Zanchi AC, 2008, INHAL TOXICOL, V20, P795, DOI 10.1080/08958370802009060

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05