Is the telomere length associated with neurocognitive disabilities in HIV-1-infected subjects?

Imagem de Miniatura
Arquivos
art_ARAUJO_Is_the_telomere_length_associated_with_neurocognitive_disabilities_2018.PDF (676.92 KB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2018
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
INST MEDICINA TROPICAL SAO PAULO
Autores
DUARTE, Wellington
OLIVEIRA, Augusto Cesar Penalva de
GASCON, Maria Rita Polo
PAIVA, Raquel de Melo Alves
SANTANA, Barbara
CALADO, Rodrigo Tocantins
Citação
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.60, article ID UNSP e16, 6p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: We evaluated the association between cognitive deficits and leukocyte telomere length (LTL) in HIV-1-infected individuals. Design: 73 HIV-1-infected patients undergoing neuropsychological evaluation and 91 healthy controls were included in this study. Fifteen HIV-1 positive patients did not have cognitive disorders whereas 26 had asymptomatic neurocognitive disorder (ANI), 13 presented mild to moderate neurocognitive disorder (MND), and 10 had HIV-associated dementia (HAD). Methods: DNA from the peripheral blood of HIV-1-infected patients was used for measurement of telomere length by real-time PCR. HIV-1 viral load was determined in blood. Results: LTL decreased with age in healthy controls (p=0.0001). Regardless of the HIV status, age-matched LTL from HIV patients, including those with ANI and MND, were shortened in comparison to the healthy control group (p=0.0073); however, no association was found among the HIV-1-infected individuals with cognitive deficits (p=0.01). In addition, no gender-related association with LTL was observed (p=0.80), smoking, physical exercise, and plasma viral load were not correlated to telomere length (p=0.66). Conclusions: We concluded that leukocyte telomere length may not be a marker of cellular senescence in individuals with HIV infection and neurocognitive disorders.
Palavras-chave
Cell aging, Neurocognitive disorders, Real-time polymerase chain reaction, AIDS, Dementia complex
URI
https://observatorio.fm.usp.br/handle/OPI/27206
Referências
  1. Antinori A, 2007, NEUROLOGY, V69, P1789, DOI 10.1212/01.WNL.0000287431.88658.8b
  2. Auld E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163153
  3. Barrett ELB, 2011, AGING CELL, V10, P913, DOI 10.1111/j.1474-9726.2011.00741.x
  4. Bekaert S, 2007, AGING CELL, V6, P639, DOI 10.1111/j.1474-9726.2007.00321.x
  5. Calado RT, 2012, LEUKEMIA, V26, P700, DOI 10.1038/leu.2011.272
  6. Calado RT, 2009, NEW ENGL J MED, V361, P2353, DOI 10.1056/NEJMra0903373
  7. Canizares S, 2014, SEMIN NEUROL, V34, P27, DOI 10.1055/s-0034-1372340
  8. Centers for Disease Control and Prevention, 2011, HIV SURV REP DIAGN H
  9. de Araujo AL, 2013, IMMUNOTHERAPY-UK, V5, P879, DOI [10.2217/imt.13.77, 10.2217/IMT.13.77]
  10. Desai Seema, 2010, Curr HIV/AIDS Rep, V7, P4, DOI 10.1007/s11904-009-0038-4
  11. Devore EE, 2011, NEUROSCI LETT, V492, P15, DOI 10.1016/j.neulet.2011.01.041
  12. Diniz LFM, 2000, REV BRAS NEUROL, V36, P79
  13. Feldser DM, 2003, NAT REV CANCER, V3, P623, DOI 10.1038/nrc1142
  14. Fitzpatrick AL, 2007, AM J EPIDEMIOL, V165, P14, DOI 10.1093/aje/kw346
  15. Giesbrecht CJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089556
  16. Greider CW, 1996, ANNU REV BIOCHEM, V65, P337, DOI 10.1146/annurev.bi.65.070196.002005
  17. Gutierrez-Rodrigues F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113747
  18. HARLEY CB, 1990, NATURE, V345, P458, DOI 10.1038/345458a0
  19. Haziot Michel Elyas Jung, 2015, Dement. neuropsychol., V9, P380, DOI 10.1590/1980-57642015DN94000380
  20. Honig LS, 2006, ANN NEUROL, V60, P181, DOI 10.1002/ana.20894
  21. Liu JCY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124426
  22. MAJ M, 1994, ARCH GEN PSYCHIAT, V51, P39
  23. Malan-Muller S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058351
  24. Martin-Ruiz C, 2006, ANN NEUROL, V60, P174, DOI 10.1002/ana.20869
  25. Oeseburg H, 2010, PFLUG ARCH EUR J PHY, V459, P259, DOI 10.1007/s00424-009-0728-1
  26. PACE GW, 1995, FREE RADICAL BIO MED, V19, P523, DOI 10.1016/0891-5849(95)00047-2
  27. Paiva RMA, 2014, PROG MOL BIOL TRANSL, V125, P133, DOI 10.1016/B978-0-12-397898-1.00006-2
  28. Palmer LD, 1997, J EXP MED, V185, P1381, DOI 10.1084/jem.185.7.1381
  29. Palmer S, 1997, P NATL ACAD SCI USA, V94, P12030, DOI 10.1073/pnas.94.22.12030
  30. Pathai S, 2014, J GERONTOL A-BIOL, V69, P833, DOI 10.1093/gerona/glt168
  31. Pathai S, 2013, AIDS, V27, P2375, DOI 10.1097/QAD.0b013e328363bf7f
  32. Rao VR, 2014, AIDS RES THER, V11, DOI 10.1186/1742-6405-11-13
  33. Raynaud CM, 2008, ANN ONCOL, V19, P1875, DOI 10.1093/annonc/mdn405
  34. Scheinberg P, 2010, JAMA-J AM MED ASSOC, V304, P1358, DOI 10.1001/jama.2010.1376
  35. Streffer C, 2009, RADIAT ENVIRON BIOPH, V49, P125
  36. von Zglinicki T, 2000, LAB INVEST, V80, P1739, DOI 10.1038/labinvest.3780184
  37. Yaffe K, 2011, NEUROBIOL AGING, V32, P2055, DOI 10.1016/j.neurobiolaging.2009.12.006
  38. Zanet DL, 2014, CLIN INFECT DIS, V58, P1322, DOI 10.1093/cid/ciu051

Coleções
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/38
Artigos e Materiais de Revistas Científicas - LIM/56
Artigos e Materiais de Revistas Científicas - ODS/03