Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

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art_FRANCA_Leishmania_infection_in_blood_donors_A_new_challenge_2018.PDF (1.53 MB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PUBLIC LIBRARY SCIENCE
Autores
FRANCA, Adriana de Oliveira
POMPILIO, Mauricio Antonio
PONTES, Elenir Rose Jardim Cury
OLIVEIRA, Marcia Pereira de
PEREIRA, Luiza Oliveira Ramos
LIMA, Rosimar Baptista
LIMA-JUNIORS, Manoel Sebastiao da Costa
Citação
PLOS ONE, v.13, n.6, article ID e0198199, 13p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Transfusion-transmitted leishmaniasis has been a concern in regions endemic for the disease. Whether immediate or delayed, the risks posed by this mode of transmission call for careful assessment. The purpose of this study was to detect Leishmania infection in blood donors living in an endemic area and to investigate progression to the disease in these individuals. Immunofluorescent antibody test, enzyme-linked immunosorbent assay, leishmaniasis rapid test, and the polymerase chain reaction were applied to 430 donors in an initial evaluation. Of those donors with at least one positive test, 50 were reevaluated four years later by the same methods, as were 25 controls who had been negative on the same tests. In the first evaluation, Leishmania infection was detected in 41.4% (95% CI: 36.7-46.1) of donors (n = 430). None of the 75 reevaluated individuals had developed the disease, but retesting revealed positivity in at least one test in 36.0% (95% CI: 25.1-46.9) of donors. Of the 50 initially testing positive, 50% remained so on retesting. Of the 25 initially negative controls, two tested positive in the subsequent evaluation. The severity of the parasitosis and the risk of transfusion transmission warrant investigation of the potential inclusion of methods for Leishmania detection into blood banks for effective screening of infected donors.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/28207
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/38