https://observatorio.fm.usp.br/handle/OPI/41306
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SANTANA, Fernanda P. R. | - |
dc.contributor.author | RICARDO-DA-SILVA, Fernanda Y. | - |
dc.contributor.author | FANTOZZI, Evelyn T. | - |
dc.contributor.author | PINHEIRO, Nathalia M. | - |
dc.contributor.author | TIBERIO, Iolanda F. L. C. | - |
dc.contributor.author | MOREIRA, Luiz Felipe Pinho | - |
dc.contributor.author | PRADO, Marco Antonio M. | - |
dc.contributor.author | PRADO, Vania F. | - |
dc.contributor.author | TAVARES-DE-LIMA, Wothan | - |
dc.contributor.author | PRADO, Carla Maximo | - |
dc.contributor.author | BREITHAUPT-FALOPPA, Ana Cristina | - |
dc.date.accessioned | 2021-08-13T15:12:10Z | - |
dc.date.available | 2021-08-13T15:12:10Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | INFLAMMATION, v.44, n.4, p.1553-1564, 2021 | - |
dc.identifier.issn | 0360-3997 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/41306 | - |
dc.description.abstract | Acute lung injury induced by intestinal ischemia/reperfusion (I/R) is a relevant clinical condition. Acetylcholine (ACh) and the alpha 7 nicotinic ACh receptor (nAChR alpha-7) are involved in the control of inflammation. Mice with reduced levels of the vesicular ACh transporter (VAChT), a protein responsible for controlling ACh release, were used to test the involvement of cholinergic signaling in lung inflammation due to intestinal I/R. Female mice with reduced levels of VAChT (VAChT-KDHOM) or wild-type littermate controls (WT) were submitted to intestinal I/R followed by 2 h of reperfusion. Mortality, vascular permeability, and recruitment of inflammatory cells into the lung were investigated. Parts of mice were submitted to ovariectomy (OVx) to study the effect of sex hormones or treated with PNU-282,987 (nAChR alpha-7 agonist). A total of 43.4% of VAChT-KDHOM-I/R mice died in the reperfusion period compared to 5.2% of WT I/R mice. The I/R increased lung inflammation in both genotypes. In VAChT-KDHOM mice, I/R increased vascular permeability and decreased the release of cytokines in the lung compared to WT I/R mice. Ovariectomy reduced lung inflammation and permeability compared to non-OVx, but it did not avoid mortality in VAChT-KDHOM-I/R mice. PNU treatment reduced lung permeability, increased the release of proinflammatory cytokines and the myeloperoxidase activity in the lungs, and prevented the increased mortality observed in VAChT-KDHOM mice. Cholinergic signaling is an important component of the lung protector response against intestinal I/R injury. Decreased cholinergic signaling seems to increase pulmonary edema and dysfunctional cytokine release that increased mortality, which can be prevented by increasing activation of nAChR alpha-7. | eng |
dc.description.sponsorship | Sao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2018/06088-0, 2014/25689-4] | - |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001] | - |
dc.description.sponsorship | National Council for Technologic and Scientific Development (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [306278/2015-4] | - |
dc.language.iso | eng | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | eng |
dc.relation.ispartof | Inflammation | - |
dc.rights | restrictedAccess | eng |
dc.subject | acute lung injury | eng |
dc.subject | experimental model | eng |
dc.subject | acetylcholine | eng |
dc.subject | PNU-282,987 | eng |
dc.subject | cholinergic anti-inflammatory pathway | eng |
dc.subject | intestinal ischemia and reperfusion | eng |
dc.title | Lung Edema and Mortality Induced by Intestinal Ischemia and Reperfusion Is Regulated by VAChT Levels in Female Mice | eng |
dc.type | article | eng |
dc.rights.holder | Copyright SPRINGER/PLENUM PUBLISHERS | eng |
dc.identifier.doi | 10.1007/s10753-021-01440-z | - |
dc.identifier.pmid | 33715111 | - |
dc.subject.wos | Cell Biology | eng |
dc.subject.wos | Immunology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | SANTANA, Fernanda P. R.:Univ Fed Sao Paulo, Dept Biol Sci, Diadema, Brazil | - |
hcfmusp.author.external | FANTOZZI, Evelyn T.:Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazil | - |
hcfmusp.author.external | PRADO, Marco Antonio M.:Univ Western Ontario, Dept Physiol & Pharmacol, Robarts Res Inst, London, ON, Canada; Univ Western Ontario, Dept Anat & Cell Biol, London, ON, Canada | - |
hcfmusp.author.external | PRADO, Vania F.:Univ Western Ontario, Dept Physiol & Pharmacol, Robarts Res Inst, London, ON, Canada; Univ Western Ontario, Dept Anat & Cell Biol, London, ON, Canada | - |
hcfmusp.author.external | TAVARES-DE-LIMA, Wothan:Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 1553 | - |
hcfmusp.description.endpage | 1564 | - |
hcfmusp.description.issue | 4 | - |
hcfmusp.description.volume | 44 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000628462900001 | - |
hcfmusp.origem.id | 2-s2.0-85102691147 | - |
hcfmusp.publisher.city | NEW YORK | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1573-2576 | - |
hcfmusp.citation.scopus | 2 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
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art_SANTANA_Lung_Edema_and_Mortality_Induced_by_Intestinal_Ischemia_2021.PDF Restricted Access | publishedVersion (English) | 846.67 kB | Adobe PDF | View/Open Request a copy |
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