Polyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescents
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Citações na Scopus
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Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
V, Gabrielle de Oliveira S. Navarro
FONSECA, Lais
TALARICO, Fernanda
SPINDOLA, Leticia
SANTORO, Marcos L.
OTA, Vanessa K.
COGO-MOREIRA, Hugo
MARI, Jair
ROHDE, Luis A.
Citação
JOURNAL OF PSYCHIATRIC RESEARCH, v.142, p.384-388, 2021
Resumo
Psychotic experiences (PE) are forms of hallucinations and delusions neither reaching the intensity and functional impairment required to be regarded as full psychotic symptoms nor a psychotic disorder. Here we investigated the ability to predict PE using multiple models (regressions, mediation and moderation) using polygenic risk score for psychotic experiences (PE-PRS), polygenic risk score for schizophrenia (SCZ-PRS), and polyenvironmental risk score (PERS) in youth from a Brazilian sample. The scores were not able to predict outcome, either when both scores were combined (PERS + PE-PRS and PERS + SCZ-PRS) or separately. Our results show that there is no association between PE and PRS or PERS among adolescents in our Brazilian sample. The lack of association may be a result of the absence of better representativeness regarding genetic and environmental factors of our population.
Palavras-chave
Psychotic experiences, Environmental, Polygenic risk score, Polyenvironmental risk score, PERS, PRS
Referências
- Barragan M, 2011, EUR PSYCHIAT, V26, P396, DOI 10.1016/j.eurpsy.2010.12.007
- Bouhaddani S., 2019, EUR CHILD ADOLES PSY, V28, P1
- Cowan H.R., 2020, EUR ARCH PSYCHIAT CL, V1, P3
- Duncan L, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11112-0
- Hanssen M, 2005, BRIT J CLIN PSYCHOL, V44, P181, DOI 10.1348/014466505X29611
- Havers L, 2019, J CHILD PSYCHOL PSYC, V60, P784, DOI 10.1111/jcpp.13045
- Jones HJ, 2016, JAMA PSYCHIAT, V73, P221, DOI 10.1001/jamapsychiatry.2015.3058
- Kelleher I, 2012, PSYCHOL MED, V42, P1857, DOI 10.1017/S0033291711002960
- Kelleher I, 2012, BRIT J PSYCHIAT, V201, P26, DOI 10.1192/bjp.bp.111.101543
- Kieling C, 2008, AM J MED GENET B, V147B, P485, DOI 10.1002/ajmg.b.30636
- Laurens KR, 2012, PSYCHOL MED, V42, P1495, DOI 10.1017/S0033291711002108
- Legge SE, 2019, JAMA PSYCHIAT, V76, P1256, DOI 10.1001/jamapsychiatry.2019.2508
- Loch AA, 2017, PSYCHIAT RES, V253, P182, DOI 10.1016/j.psychres.2017.03.052
- McGrath JJ, 2015, JAMA PSYCHIAT, V72, P697, DOI 10.1001/jamapsychiatry.2015.0575
- Moriyama TS, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00782
- National Institute of Mental Health, 1997, GEN MENT DIS REP NAT
- Padmanabhan JL, 2017, SCHIZOPHR RES, V181, P17, DOI 10.1016/j.schres.2016.10.014
- Pain O, 2018, AM J MED GENET B, V177, P416, DOI 10.1002/ajmg.b.32630
- Pan PM, 2019, SCHIZOPHR RES, V205, P23, DOI 10.1016/j.schres.2018.06.044
- Poulton R, 2000, ARCH GEN PSYCHIAT, V57, P1053, DOI 10.1001/archpsyc.57.11.1053
- Ripke S., 2020, MAPPING GENOMIC LOCI, DOI [10.1101/2020.09.12.20192922, DOI 10.1101/2020.09.12.20192922,2020.09.12.20192922]
- Roelfs D., TRANSL PSYCHIAT, V11, P1
- Salum GA, 2015, INT J METH PSYCH RES, V24, P58, DOI 10.1002/mpr.1459
- Sieradzka D, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094398
- Talarico F, 2019, SCHIZOPHR RES, V204, P404, DOI 10.1016/j.schres.2018.07.026
- van Os J, 1999, SOC PSYCH PSYCH EPID, V34, P459, DOI 10.1007/s001270050220
- van Os J, 2009, PSYCHOL MED, V39, P179, DOI 10.1017/S0033291708003814
- Vassos E, 2020, PSYCHOL MED, V50, P2213, DOI 10.1017/S0033291719002319
- Welham J, 2009, PSYCHOL MED, V39, P625, DOI 10.1017/S0033291708003760
- Wigman JTW, 2011, SCHIZOPHRENIA BULL, V37, P850, DOI 10.1093/schbul/sbp154
- Yung AR, 2016, WORLD PSYCHIATRY, V15, DOI 10.1002/wps.20328